CAS: 107818-20-2; Thieno[3,2-B]Pyridin-7-Ol

相似化合物

953045-90-4 875340-62-8 115063-93-9

上下游产品

2,2-dimethyl-5-{[(thiophen-3-yl)amino]methylidene}-1,3-dioxane-4,6-dione7-[(1R)-(3-chloro-1-phenyl-propoxy)]-thieno[3,2-b]pyridine 7-bromothieno[3,2-b]pyridine 4-[2-hydroxy-4-(5-methanesulfonyl-2,3-dihydrobenzofuran-7-yl)-4-methyl-2-trifluoromethylpentyl]-4H-thieno[3,2-b]pyridin-7-one

2,2-Dimethyl-5-((Thiophen-3-Ylamino)Methylene)-1,3-Dioxane-4,6-Dione 以 二苯醚 用作溶剂,化学反应生成7-羟基噻吩并[3,2-B]吡啶
参考文献:大规模制备咪唑-噻吩并吡啶的交叉偶联方法:[2-(3-Methyl-3H-Imidazol-4-yl)-Thieno[3,2-B]Pyridin-7-Yl]-的合成(2-甲基-1H-吲哚-5-基)-胺
标题:大规模制备咪唑-噻吩并吡啶的交叉偶联方法:[2-(3-Methyl-3H-Imidazol-4-yl)-Thieno[3,2-B]Pyridin-7-Yl]-的合成(2-甲基-1H-吲哚-5-基)-胺
摘要:[2-(3-Methyl-3H-Imidazol-4-yl)-Thieno[3,2-B]Pyridin-7-Yl]-(2-Methyl-1H-Indol-5-yl)的数百克合成)-胺 (1) 描述了利用碘噻吩并吡啶 (3) 与 5-(三丁基甲锡烷基)-1-甲基咪唑 (11) 的 Stille 交叉偶联.评估了几种交叉偶联方法将噻吩并吡啶 3 转化为咪唑-噻吩并吡啶 2,但只有两种方法有效:Stille 偶联和源自 2-(叔丁基二甲基甲硅烷基)-1-的有机锌试剂的 Negishi 交叉偶联甲基咪唑和碘噻吩并吡啶 (3).后一种方法在实验室规模 (<50 G) 上运行非常好,但在放大时反复无常.讨论了有机锡烷试剂放大的问题,包括有机锡水平的控制和分析.
Doi:10.1021/op0340457

专利信息

专利号:US-11286268-B1
优先权日:2019-07-02
标题:EIF4E-inhibiting compounds and methods
发明人：SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.