CAS: 1119-33-1; H-Glu(Oet)-Oh

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CAS号64-17-5 乙醇 | CAS号56-86-0 L-谷氨酸 | CAS号16450-41-2 谷氨酸二乙酯 | CAS号4124-76-9 benzyl N-(2,6-d... | CAS号35726-62-6 N-Cbz-L-谷氨酸-5-乙酯 | CAS号1955-67-5 L-Glutamic acid... | CAS号1820-73-1 L-谷氨酸=gamma-肼 | CAS号487-79-6 海藻酸(mM/ml) | CAS号70-18-8 谷胱甘肽/5-L-谷氨酰-L-... | CAS号56-86-0 L-谷氨酸 | CAS号64-17-5 乙醇 | CAS号98-79-3 L-焦谷氨酸 | CAS号10138-10-0 4-氧代丁酸乙基酯 | CAS号149-87-1 DL-焦谷氨酸

谷氨酸二乙酯置于sodium Hydroxide体系中,化学反应 1.5H,以76%的收率获得l-谷氨酸5乙脂
参考文献:高效甜味剂的合成,Nc-00637.第 3 部分:谷氨酰部分和偶联反应
标题:高效甜味剂的合成,Nc-00637.第 3 部分:谷氨酰部分和偶联反应
摘要:高效甜味剂 Nc-00637 (1) 的合成需要选择性制备 γ-保护的谷氨酸.三种组分的偶联可以以任何顺序进行,但最终路线涉及受保护的 L-谷氨酸与衍生自 (S)-2-甲基己酸的酰氯的 N-酰化.α-羧基的活化允许与 5-氨基-2-氰基吡啶 (4) 缩合.γ-酯 19 的皂化然后提供甜味剂 1.
Doi:10.1021/op0341115

专利信息

专利号:US-6133242-A
优先权日:1993-10-15
标题 :Inhibition of extracellular matrix synthesis by antisense compounds directed to nuclear proto-oncogenes
发明人：ZALEWSKI ANDREW; SHI YI
权利人:THOMAS JEFFERSON UNIVERISITY
摘要:A method and compounds are provided for inhibiting the synthesis of extracellular matrix proteins. Compounds of the invention comprise antisense oligonucleotides specific for nuclear proto-oncogenes. Preferably, antisense compounds of the invention are selected from the group consisting of c-myc and c-myb and are locally administered. The invention finds use in the treatment of a variety of disorders, including sclerotic disorders and restenosis, associated with the inappropriate synthesis of extracellular matrix proteins, particularly collagen.

专利号:US-2017283878-A1
优先权日:2015-12-11
标题:Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
发明人：WONG CHI-HUEY; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI; HSU TSUI-LING
权利人:ACADEMIA SINICA
摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for diagnostic and therapeutic uses.

专利号:US-5116947-A
优先权日:1988-12-23
标题:Process for the preparation of retro-inverso peptides and new intermediates thereof
发明人：PINORI MASSIMO; CENTINI FELICE; VERDINI ANTONIO S
权利人:SCLAVO SPA
摘要:A method of synthesis of a partially retro-inverso peptide incorporating at least one malonyl residue of formula (III) ##STR1## wherein R represents the side chain of an α-amino acid, is described which is characterized in that said malonyl residue is incorporated by condensing a 5-substituted-2,2-dimethyl-1,3-dioxane-4,6-dione of formula (IV) ##STR2## wherein R' is the side-chain R wherein the functional groups, if any, are suitably protected, with an amino acid, amino acid amide, peptide fragment, or pseudo-peptide fragment wherein the terminal carboxyl group, if present, and the possible side-chain functionalities are suitably protected and the reactive amino group is tri-alkyl-silylated. n The new compounds of formula (VI) and a process for the preparation of a partially retro-inverso tuftsin analog which involves use of said method and said intermediate are also described and claimed.

专利号:US-5049488-A
优先权日:1985-11-08
标题:Method and nucleic acid for the preparation of lecithin:cholesterol acyltransferase
发明人：BAER BRADFORD W; DRAYNA DENNIS T; LAWN RICHARD M; MCLEAN JOHN W
权利人:GENENTECH INC
摘要:Nucleic acid encoding lecithin:cholesterol acyltransferase is ligated into expression vectors and used to transform host cells for the synthesis of lecithin:cholesterol acyltransferase in recombinant cell culture. Lecithin:cholesterol acyltransferase amino acid sequence variants are described for enhancing the properties of lecithin:cholesterol acyltransferase. Lecithin:cholesterol acyltransferase and its variants are employed in the therapy of conditions characterized by hypercholesterolemia and for the mobilization of cholesterol in vivo.

专利号:US-5264357-A
优先权日:1985-05-24
标题:Nucleic acids vectors and cells for the synthesis of membrane anchor fusion polypeptides
发明人：CARAS INGRID W; DAVITZ MICHAEL A; NUSSENZWEIG VICTOR; MARTIN JR DAVID W
权利人:GENENTECH INC
摘要:Novel fusions of a phospholipid anchor domain and a polypeptide heterologous to the anchor domain donor polypeptide are provided for industrial use. Therapeutic administration of the fusions enables the targeting of biological activity to cell membrane surfaces.

专利号:US-6323184-B1
优先权日:1993-10-15
标 题:Arteriovenous and venous graft treatments: methods and compositions
发明人：ZALEWSKI ANDREW; SHI YI
权利人:UNIV JEFFERSON
摘要:A method and compounds are provided for inhibiting the synthesis of extracellular matrix proteins. Compounds of the invention comprise oligonucleotides specific for nuclear proto-oncogenes. Preferably, oligonucleotides of the invention are selected from the group consisting of c-myc and c-myb and are locally administered. The invention finds use in the treatment of a variety of disorders, including sclerotic disorders and restenosis, associated with the inappropriate synthesis of extracellular matrix proteins, particularly collagen.