专利号:US-2012203004-A1 优先权日:2009-08-13 标题 :process for the synthesis of alkyl/aralkyl (2s)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof: key intermediates for the preparation of dppiv inhibitors 发明人:ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA 权利人:ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA; LUPIN LTD 摘要:An improved process for the synthesis of intermediates like Alkyl/Aralkyl (2S)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof which are useful in the synthesis of Dipeptidyl peptidase-IV (DP-PIV) inhibitors.
专利号:US-6420599-B2 优先权日:1998-05-29 标 题:Chemical process for the stereoselective synthesis of R-(-)-carnitine 发明人:MARZI MAURO; TINTI MARIA ORNELLA; DE ANGELIS FRANCESCO 权利人:SIGMA TAU IND FARMACEUTI 摘要:A process is described for the stereoselective synthesis of R-(-)-carnitine in which the characterizing step is condensation of glycerol with an amine of (-)camphorsulfonic acid.
专利号:WO-0242243-A1 优先权日:2000-11-21 标 题 :Processes for preparation of tetrahydronaphthalene derivatives 发明人:ICHIHARA MASAHARU; HASHIMOTO NORIO; OHIGASHI ATSUSHI; KANDA ATSUSHI; KAGARA KOOJI; MORIKI SHIGERU; BABA YUKIHISA 权利人:FUJISAWA PHARMACEUTICAL CO; ICHIHARA MASAHARU; HASHIMOTO NORIO; OHIGASHI ATSUSHI; KANDA ATSUSHI; KAGARA KOOJI; MORIKI SHIGERU; BABA YUKIHISA 摘要:Processes for preparing optically active intermediates for the synthesis of tetrahydronaphthalene derivatives useful as PGI2 agonist can be provided by providing a method for optical resolution of a tetrahydronaphthalene derivative of the following general formula with a reagent for optical resolution and a method for inversion of such a derivative at its asymmetric center. In the formula, R1 is a hydroxyl-protecting group; R2 is hydrogen or halogeno; R3 is hydrogen, hydroxyl, or protected hydroxyl; and R4 is hydrogen, hydroxyl, protected hydroxyl, lower alkyl, or halogeno.
专利号:CN-103724228-B 优先权日:2012-10-12 标 题 :The novel method of synthesis 3-(2-bromo-4,5-dimethoxy phenyl) propionitrile and the application in the additive salt of synthesis of ivabradine and itself and pharmaceutically acceptable acid
专利号:CN-103724228-A 优先权日:2012-10-12 标 题 :A new method for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propionitrile and its application in the synthesis of ivabradine and its addition salts with pharmaceutically acceptable acids
专利号:CN-104017832-A 优先权日:2013-02-28 标题:Enzymatic synthesis of (7S)-3,4-dimethoxybicyclo[4.2.0]oct-1,3,5-triene-7-carboxylic acid and its application in the synthesis of ivabradine and its salts application