CAS: 134150-01-9; (4-Propylphenyl)Boronic Acid

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145240-28-4 121219-12-3 63139-21-9

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CAS号121-43-7 硼酸三甲酯 | CAS号2114-36-5 1-溴丙基苯 | CAS号588-93-2 4-丙基溴苯 | CAS号17763-80-3 4-硝基苯基三氟甲磺酸酯 | CAS号10342-59-3 1-硝基-4-正-丙基苯 | CAS号2696-84-6 对丙基苯胺 | CAS号126261-84-5 4-正丙基碘苯

4-硝基苯酚三氟甲基磺酸酯置于2-双环己基膦-2',6'-二甲氧基联苯,盐酸,Potassium Phosphate Monohydrate,Potassium Hydrogen Fluoride,Palladium On Activated Charcoal,氢气,Palladium Diacetate,三乙胺,Sodium Nitrite体系中,用 1,4-二氧六环,甲醇,乙醇,水,甲苯 用作溶剂,化学反应 1.5H,反应生成4-丙基苯硼酸
参考文献:Design And Synthesis Of Boronic Acid Inhibitors Of Endothelial Lipase
标题:Design And Synthesis Of Boronic Acid Inhibitors Of Endothelial Lipase
摘要:Endothelial Lipase (El) And Lipoprotein Lipase (Lpl) Are Homologous Lipases That Act On Plasma Lipoproteins. El Is Predominantly A Phospholipase And Appears To Be A Key Regulator Of Plasma Hdl-C. Lpl Is Mainly A Triglyceride Lipase Regulating (V)Ldl Levels. The Existing Biological Data Indicate That Inhibitors Selective For El Over Lpl Should Have Anti-Atherogenic Activity,Mainly Through Increasing Plasma Hdl-C Levels. We Report Here The Synthesis Of Alkyl,Aryl,Or Acyl-Substituted Phenylboronic Acids That Inhibit El. Many Of The Inhibitors Evaluated Proved To Be Nearly Equally Potent Against Both El And Lpl,But Several Exhibited Moderate To Good Selectivity For El. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2011.12.043

专利信息

专利号:US-12187735-B2
优先权日:2018-09-17
标 题:Matter of composition, synthesis, formulation and application of FL118 platform positions 7 and 9-derived analogues for treatment of human disease
发明人：LING XIANG; LI QINGYONG; LI FENGZHI
权利人:CANGET BIOTEKPHARMA LLC
摘要:Described herein, are the chemical synthesis, matter of compositions, formulation, function, methods and uses of the FL118 platform Positions 7 and/or 9-derived analogues for treating cancer or other human diseases. Compounds derived from chemical modifications of the FL118 platform are employed alone or in combination with other anti-cancer agents to preclude, eliminate or reverse cancer phenotypes. This invention intends to realize unique personalized cancer treatment (personalized precision medicine) through application of a series of structural relevant individual FL118 platform-derived analogues, which target multiple cellular human disease-relevant proteins and their signaling pathways.

专利号:US-2025092058-A1
优先权日:2018-09-17
标 题 :Matter of composition, synthesis, formulation and application of fl 118 platform positions 7 and 9-derived analogues for treatment of human disease
发明人：LING XIANG; LI QINGYONG; LI FENGZHI
权利人:CANGET BIOTEKPHARMA LLC
摘要:Described herein, are the chemical synthesis, compounds, methods and uses of the fluoroaryl-substituted derivatives at the FL118 position 7, which target multiple cellular human disease-relevant proteins and their signaling pathways.

专利号:US-8350100-B2
优先权日:2002-03-15
标题 :Process for the preparation of ring compounds
发明人：PAULUTH DETLEF; KIRSCH PEER; BAEUERLE PETER; DEEG OLIVER
权利人:MERCK PATENT GMBH; PAULUTH DETLEF; KIRSCH PEER; BAEUERLE PETER; DEEG OLIVER
摘要:In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling; subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.

专利号:US-7851658-B2
优先权日:2004-08-17
标 题:Palladium-catalyzed carbon-carbon bond forming reactions
发明人：LIU DAVID R; KANAN MATTHEW W; ROZENMAN MARY M
权利人:HARVARD COLLEGE
摘要:A novel palladium-mediated carbon-carbon bond forming reaction has been discovered using DNA-templated chemistry. The inventive reaction involves the palladium-mediated coupling of a terminal alkyne with an alkene to form an enone. A catalytic amount of palladium may be used in the reaction if an oxidant is present. The reactions is also compatible with a variety of organic solvent as well as aqueous solution. Both intermolecular and intramolecular reactions have been demonstrated. This novel carbon-carbon bond forming reaction is particularly useful in the synthesis of macrocycles. Kits, reagents, catalysts, solvents, oxidants, salts, acids, instructions, and other materials useful in the practice of the inventive reaction are also provided.

专利号:US-9879037-B2
优先权日:2012-03-30
标 题 :Fluorine-containing phosphate ester-amide, and flame retardant resin, flame retardant liquid and flame retardant solvent for organic synthesis containing same
发明人：MIMURA HIDEYUKI; FUJITA HIROAKI; EGUCHI HISAO
权利人:TOSOH F-TECH INC
摘要:[Problem] To provide a fluorine-containing phosphate ester-amide which has high flame retardancy such as exhibiting flame retardant effects at a small quantity of addition, and sufficient hydrolysis resistance. n [Solution] A fluorine-containing phosphate ester-amide represented by general formula (1). (In the formula, R1 and R2 are the same or different and represent a branched or linear alkyl group having 1 to 20 carbon atoms in which at least one carbon bonded to a nitrogen atom is a secondary or tertiary carbon, wherein R1 and R2 may have a substituent group selected from the group consisting of an alkoxy group, a hydroxy group, an amino group, a methyl amino group, an ethyl amino group, a dimethyl amino group, diethyl amino group and a fluorine atom. In addition, R1 and R2 may be bonded together to form a five- to eight-membered cyclic structure. X and Y are the same or different and represent a hydrogen atom or a fluorine atom, and n and m represent an integer of 1 to 6.)

专利号:CA-3111403-A1
优先权日:2018-09-17
标 题:Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease