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专利信息

专利号:US-2011105751-A1
优先权日:2008-03-31
标题:Conversion of tryptophan into beta-carboline derivatives
发明人：PIRC SAMO
权利人:LEAK PHARMACEUTICALS D D
摘要:The invention belongs in the field of organic chemistry and relates to a new shortened Pictet-Spengler type reaction for preparing isomerically pure β-carboline compounds useful for the synthesis of tadalafil.

专利号:US-8829023-B2
优先权日:2011-02-10
标题 :Process for obtaining compounds derived from tetrahydro-β-carboline
发明人：BERZOSA RODRÃ?GUEZ XAVIER; MARQUILLAS OLONDRIZ FRANCISCO
权利人:BERZOSA RODRÃ?GUEZ XAVIER; MARQUILLAS OLONDRIZ FRANCISCO; INTERQUIM SA
摘要:The invention relates to a process for obtaining compounds derived from tetrahydro-β-carboline, specifically tadalafil and intermediate products from the synthesis, comprising the reaction between piperonal and an alkyl ester of D-tryptophan as a salt, and in the absence of any other component, followed by haloacetylation and a final cyclization with methylamine.