CAS: 247068-82-2; Tert-Butyl ((S)-4-Methyl-1-((R)-2-Methyloxiran-2-yl)-1-Oxopentan-2-yl)Carbamate

相似化合物

2177287-68-0 247068-83-3 2381627-87-6

上下游产品

CAS号247068-81-1 (S)-(2,6-二甲基-3-... | CAS号87694-50-6 N-(叔丁氧基羰基)-L-亮氨... | CAS号13139-15-6 B°C-L-亮氨酸

Boc-D-亮氨酸置于c30H36F6Mnn6O6S2,双氧水,碘,Magnesium,溶剂黄146,1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 四氢呋喃,2-甲基四氢呋喃,甲基叔丁基醚,水,乙腈 用作溶剂,化学反应 56.42H,反应生成N-[(2S)-4-甲基-1-[(2R)-2-甲基环氧乙烷-2-基]-1-氧代-2-戊基]氨基甲酸叔丁酯
参考文献:卡非佐米生产中的连续工艺改进,第2部分:合成环氧酮战斗部的改进方法
标题:卡非佐米生产中的连续工艺改进,第2部分:合成环氧酮战斗部的改进方法
摘要:描述了改进的合成卡菲佐米环氧酮战斗部的方法的发展和千克规模的演示.该过程成功的关键在于:(1)开发可扩展的不对称环氧化方案;(2)鉴定具有改善的物理性质的结晶中间体以进行分离;(3)发现和优化差向异构化条件以设定目标立体化学;(4)引入晶种床共结晶,以促进最终低熔点目标的分离.共享了公斤级示范运行的结果,包括安全执行放热的barbier型格氏试剂的连续过程的详细信息.
Doi:10.1021/acs.Oprd.0C00052

专利信息

专利号:US-11708341-B2
优先权日:2016-08-05
标题:Synthesis of (S)-2-amino-4-methyl-((R)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof
发明人：Beaver Matthew; CUI SHENG; SHI XIANGQING
权利人:AMGEN INC
摘要:The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure n nCompound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.

专利号:US-8921583-B2
优先权日:2007-10-04
标题:Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
发明人：PHIASIVONGSA PASIT; SEHL LOUIS C; FULLER WILLIAM DEAN; LAIDIG GUY J
权利人:ONYX THERAPEUTICS INC
摘要:The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides.

专利号:US-9822145-B2
优先权日:2014-10-27
标题:Methods of making carfilzomib and intermediates thereof
发明人：KOVI RAVISHANKER; KANNAPAN JAYARAMAN; RAMU VASANTHAKUMAR G; PRASAD ALAPARTHI LAKSHMI; CHOWDARY TALLURI BHUSHAIAH; KULKARNI GAURAV; AHMED SAIYED AKEEL AHMED SHAKEEL; BOBBILI VEERABHADRA RAO; DUSANAPUDI N V RAGHAVALU; MANTRI ANAND V
权利人:APICORE US LLC
摘要:Racemization-free methods are disclosed for the synthesis of carfilzomib. Novel intermediates and methods of making carfilzomib employing fragment condensation using the novel intermediates are disclosed. Amorphous carfilzomib and methods of making same are disclosed.

专利号:CN-109641863-B
优先权日:2016-08-05
标 题 :Synthesis of intermediates for the synthesis of carfilzomib and its pharmaceutically acceptable salts

专利号:US-2016194354-A1
优先权日:2013-09-06
标 题 :Stereoselective synthesis of diols and triols by mannich reaction and their use in the synthesis of carfilzomib
发明人：HÖFERL-PRANTZ KATHRIN; WILHELM THORSTEN
权利人:SANDOZ AG
摘要:It is provided an improved process for preparing Carfilzomib, including novel compounds that can be used as intermediates in the process for preparing Carfilzomib.

专利号:EP-3494108-B1
优先权日:2016-08-05
标 题:Synthesis of (s)-2-amino-4-methyl-1-((r)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof