CAS: 3250-73-5; 2-(2-Ethoxyphenoxy)Ethanol

上下游产品

2-Ethoxyphenol 2-chloro-ethanol [1,3]-dioxolan-2-one 2-(2-ethyloxyphenoxy)ethyl methanesulfonate (R)-tamsulosin tamsulosin hydr°Chloride

邻乙氧基苯酚,2-氯乙醇置于sodium Hydroxide体系中,用 水 用作溶剂,化学反应 48.0H,以77%的收率获得2-(2-乙氧基-苯氧基)-乙醇
参考文献:Process For Preparation Of Tamsulosin And Its Aralkylamine Derivatives
标题:Process For Preparation Of Tamsulosin And Its Aralkylamine Derivatives
摘要:本发明公开了一种合成坦洛新及其芳基胺衍生物的新工艺,特别是具有以下化学式1的(R)-(−)-5-{2-[2-(2-烷氧基苯氧基)乙基氨基]丙基}-2-烷氧基苯磺酰胺(其中r1和r2代表c1-C4烷基基团)及其盐酸盐,以及其他各种药用盐.坦洛新盐酸盐(r1=et,R2=me,在其盐酸盐形式中)是前列腺α-A肾上腺素受体的拮抗剂.坦洛新•hcl呈白色晶体,约在230oc左右分解熔化.它在水和甲醇中溶解度较低,在冰乙酸和乙醇中稍溶,在醚中几乎不溶.

专利信息

专利号:US-7619116-B2
优先权日:2003-12-17
标 题:Intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation
发明人：DAMBRIN VALERY; LENOIR JEAN-YVES; SCHNEIDER JEAN-MARIE; GUILLAMOT GERARD; FOLLET MICHEL; BECKER ABRAM
权利人:PRODUCTS CHIMIQUES AUXILIAIRES
摘要:A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.

专利号:US-7282606-B2
优先权日:2005-07-13
标题:Process for preparation of tamsulosin and its aralkylamine derivatives
发明人：JIH RU HWU; TSAY SHWU CHEN; MAGENDRAN BALAACHARY; CHAKRABORTY SUBHASISH K; DAS ASISH R; SHEU KUEN WANG; SHU CHUN MEI; LU CHIN KUN; CHANG WEI MIN
权利人:TAIWAN BIOTECH CO LTD
摘要:The present invention discloses a new process for the synthesis of tamsulosin and its aralkylamine derivatives, especially (R)-(−)-5-{2-[2-(2-alkoxyphenoxy) ethylamino]propyl}-2-alkoxybenzenesulfonamides having the following formula 1 (where R 1 and R 2 represent C 1 -C 4 alkyl groups) and their hydrochloride thereof, and other various pharmaceutical used salts. n n n n n n n n n n Tamsulosin hydrochloride (R 1 =Et, R 2 =Me, in its hydrochloride salt form) is an antagonist of α-A adrenoceptors in the prostate. Tamsulosin•HCl occurs as white crystals, which melt with decomposition at approximately 230° C. It is sparingly soluble in water and in methanol, slightly soluble in glacial acetic acid and in ethanol, and practically insoluble in ether.

专利号:US-2007106079-A1
优先权日:2003-12-17
标题:Novel intermediates for the synthesis of (r)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation

专利号:WO-2005058810-A1
优先权日:2003-12-17
标题:Novel intermediates for the synthesis of (r)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation

专利号:EP-1697316-B1
优先权日:2003-12-17
标题 :Novel intermediates for the synthesis of (r)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation

专利号:EP-1697316-A1
优先权日:2003-12-17
标 题 :Novel intermediates for the synthesis of (r)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation