2-甲氧基-3-硝基吡啶置于乙酸铵体系中,用 水 作为反应溶剂,化学反应生成 2-氨基-3-硝基吡啶 参考文献:Process For The Synthesis Of Intermediates In The Preparation Of 标题:Process For The Synthesis Of Intermediates In The Preparation Of 摘要:本发明涉及一种制备氨基硝基吡啶的过程,包括将烷氧基硝基吡啶与乙酸铵反应.
专利号:US-9708317-B2 优先权日:2013-11-25 标 题 :Process for the preparation of 8-(4-aminophenoxy)-4H-pyrido[2,3-B]pyrazin-3-one derivatives 发明人:ZAMBON ALFONSO; NICULESCU-DUVAZ DAN; CHUBB RICHARD; SPRINGER CAROLINE JOY 权利人:CANCER RES TECH LTD; INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE); OXY SCIENT LTD; THE INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL 摘要:The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of 8-(4-aminophenyoxy)-4H-pyrido[2,3-b]pyrazin-3-one and related compounds (denoted herein as (3)) from 4-(4-aminophenyoxy)pyridine-2,3-diamine and related compounds (denoted herein as (1)), by reaction with glyoxylic acid (denoted herein as (2)). The compounds (3) are useful in the synthesis of known anti-cancer agents, such as 1-(5-tert-butyl-2-(4-methyl-phenyl)-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea.
专利号:US-8115007-B2 优先权日:2007-11-27 标题:Synthesis of diaminodinitropyridine 发明人:DINDI HASAN; SCHULTZ JAMES ARNOLD 权利人:DINDI HASAN; SCHULTZ JAMES ARNOLD; DU PONT 摘要:A process for the preparation of diaminodinitropyridine or diaminodinitrobenzene by contacting an aminopyridine or aminobenzene with oleum and nitric acid, wherein the improvement comprises adding at least about 1% molar excess of nitric acid, based upon the aminopyridine or aminobenzene with stirring for at least two hours to form first the intermediate sulfonic acid, and then diaminodinitropyridine or diaminodinitrobenzene, and use of such products in the preparation of rigid rod polymers is disclosed.
专利号:WO-2022213975-A1 优先权日:2021-04-08 标题:Compounds targeting y220c mutant of p53 发明人:LI SUJING; LI AMIN; ZHENG QIAN; Dang Chaojie; FAN XINRUI; LONG WEI; WANG YANPING 权利人:JACOBIO PHARMACEUTICALS CO LTD 摘要:Provided are compounds of formula (I) which can bind to p53 mutant and restore its ability to bind DNA and activate downstream effects involved in tumor suppression. Also provided are the synthesis processes and use of the compounds.
专利号:US-2009137814-A1 优先权日:2007-11-27 标 题 :Synthesis of diaminodinitropyridine
专利号:US-3963734-A 优先权日:1971-09-17 标 题:Lower alkylsulfonyl 2-amino, 3-nitro pyridines 发明人:DOHERTY GEORGE O P; FUHR KENNETH H 权利人:LILLY CO ELI 摘要:Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.
专利号:US-4087432-A 优先权日:1974-05-23 标 题 :1H-imidazo(4,5-b)pyridine compounds 发明人:O DOHERTY GEORGE O P; FUHR KENNETH H 权利人:LILLY CO ELI 摘要:Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.
[参考文献]: Monika Ermann, Et Al. Solid-Phase Synthesis Of Imidazo[4,5-B]Pyridin-2-Ones And Related Urea Derivatives By Cyclative Cleavage Of A Carbamate Linkage. J Comb Chem. 2002 Jul-Aug;4(4):352-8.
合成参考文献
摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 236. 摘要:Shen, Q.; Guo, F.; Hartwig, J. F., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 188. 摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp. 摘要:D.J. Brown and J.S. Harper. J. Chem. Soc. 1965, 5542.