CAS: 72235-52-0; (2,4-Difluorophenyl)Methanamine

上下游产品

CAS号3939-09-1 2,4-二氟苯腈

1,3-二氟苯置于氯化亚砜,溴,臭氧,硝基苯,Sodium Chloride体系中,用 二氯甲烷,氯苯 作为反应溶剂,化学反应 8.0H,反应生成 2,4-二氟苄胺
参考文献:一种度鲁特韦关键中间体2,4-二氟苄胺制备 的路线
标题:一种度鲁特韦关键中间体2,4-二氟苄胺制备 的路线
摘要:本发明公开了一种路线简洁的,绿色的,低成本的2,4‑二氟苄胺的易于工业化的生产路线,分为以下四个步骤:A).以间二氟苯为起始原料,在路易斯酸的催化下与环氧乙烷发生傅科烷基化反应,制备中间产物2,4‑二氟苯乙醇;b).步骤a)产物不经分离纯化直接进行第二步反应,将2,4‑二氟苯乙醇氧化反应生成2,4‑二氟苯乙酸;c).步骤b)产物2,4‑二氟苯乙酸与氯化亚砜,氨气反应制备2,4‑二氟苯乙酰胺;d).步骤c)产物2,4二氟苯乙酰胺在溴素的诱导下与次氯酸钠水溶液反应,发生霍夫曼降解,制备目标产物2,4‑二氟苄胺.本发明制备方法原料简单易得,路线简洁,绿色环保,低成本,易于工业化的生产.

专利信息

专利号:US-9926291-B2
优先权日:2007-03-27
标 题 :Synthesis of thiohydantoins
发明人：OUERFELLI OUATHEK; DILHAS ANNA; YANG GUANGBIN; ZHAO HONG
权利人:SLOAN KETTERING INST CANCER RES
摘要:A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.

专利号:WO-9931124-A1
优先权日:1997-12-12
标 题:Cholic acid-based scaffolds for multidimensional molecular presentation of peptides
发明人：HOEEG-JENSEN THOMAS
权利人:NOVO NORDISK AS; HOEEG JENSEN THOMAS
摘要:A solid phase method for the synthesis of a plurality of differently substituted cholic acid scaffolds with a wide variety of peptide chain, pseudo-peptide chain or peptoid chain substitutents, as leads or compounds of potential therapeutic interest. The substituted cholic acids are prepared by initial solution synthesis of a scaffold holding amino acids with 3 orthogonal protecting groups. Subsequent solid-phase synthesis provides the build-up of the target molecules, either as discretes or in mixture. The molecules may be screened on the resin or cleaved from the resin and then screened in solution. The method disclosed here provides an easy and fast access to highly diverse compounds, potential peptide mimetics and potential leads for compounds of therapeutic interest. The method is amenable to automatization.

专利号:US-6906046-B2
优先权日:2000-12-22
标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes
发明人：JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY
权利人:CELLTECH R & D INC
摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.

专利号:US-2025049791-A1
优先权日:2023-08-03
标题:Synthesis of MEK7 Inhibitors and methods of Use Thereof
发明人：SCHEIDT KARL A; KIM DALTON ROBERT; ORR MEGHAN JO
权利人:UNIV NORTHWESTERN
摘要:Disclosed herein are 4-phenoxypyrimidine compounds and derivatives thereof for use as inhibitors of mitogen-activated protein kinase 7 (MEK7). The disclosed compounds and pharmaceutical compositions thereof may be used in methods for treating a disease or disorder associated with MEK7 activity, including cell proliferative diseases and disorders associated with MEK7 activity, such as cancer.

专利号:US-10975096-B2
优先权日:2014-06-20
标题 :Synthesis of polycyclic-carbamoylpyridone compounds
发明人：CHIU ANNA; ENQUIST JR JOHN; GRIGGS NOLAN; HALE CHRISTOPHER; IKEMOTO NORIHIRO; KEATON KATIE ANN; KRAFT MATT; LAZERWITH SCOTT E; LEEMAN MICHEL; PENG ZHIHUI; SCHRIER KATE; TRINIDAD JONATHAN; VAN HERPT JOCHEM; WALTMAN ANDREW W
权利人:GILEAD SCIENCES INC
摘要:Methods of making compounds of Formula I are disclosed:

专利号:US-9365587-B2
优先权日:2008-12-11
标 题:Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
发明人：YOSHIDA HIROSHI; TAODA YOSHIYUKI; JOHNS BRIAN ALVIN; KAWASUJI TAKASHI; NAGAMATSU DAIKI
权利人:SHIONOGI & CO; VIIV HEALTHCARE CO
摘要:The invention is a process for the preparation of a compound of the following formula (I): n nwherein R is —CHO, —CH(OH) 2 or —CH(OH)(OR 4 ); P 1 is H or a hydroxyl protecting group; P 3 is H or a carboxy protecting group; R 3 is H, halogen, hydroxy, optionally substituted lower alkyl, optionally substituted cycloalkyl, etc.; R x is H, halogen or R 2 —X—NR 1 —C(O)—; etc. as defined in the specification. The compounds are useful as intermediates in synthesizing compounds having HIV integrase inhibitory activity.