CAS: 72811-73-5; 4-(M-Tolylamino)Pyridine-3-Sulfonamide

上下游产品

CAS号777854-85-0 4-氯吡啶-3-磺酰胺盐酸盐 | CAS号108-44-1 3-甲基苯胺 | CAS号33263-43-3 4-氯吡啶-3-磺酰胺 | CAS号56211-40-6 托拉塞米 | CAS号72810-57-2 [[4-[(3-Methylp...

在 Ammonium Hydroxide,N-氯代丁二酰亚胺,溶剂黄146,三乙胺,三氟乙酸体系中,用 二氯甲烷,水,乙腈 作为反应溶剂,化学反应 18.0H,反应生成 4-(3-甲基苯基)氨基吡啶-3-磺酰胺
参考文献:一种托拉塞米关键中间体的合成方法
标题:一种托拉塞米关键中间体的合成方法
摘要:本发明涉及了一种托拉塞米关键中间体(vii)的合成方法,具有以下步骤:1)起始原料(i)经叔丁氧羰基(boc)保护氨基得到中间体(II),2)中间体(II)再经苄基保护巯基得到中间体(iii),3)中间体(iii)经氧化氯代反应得到中间体(iv),4)中间体(iv)经氨化反应得到中间体(v),5)中间体(v)经脱保护得到中间体(vi),6)中间体(vi)再与间氯甲苯反应得到托拉塞米关键中间体(vii)).该合成方法不使用高污染试剂和高危险性试剂,本发明为首次报道,本发明提出的制备方法具有原料易得,成本低廉,三废量少,方法简单,条件温和,操作方便,产品纯度高,适合工业化生产等特点,可应用于托拉塞米的生产.

专利信息

专利号:US-2004138469-A1
优先权日:2002-12-23
标 题 :Process for the synthesis of torsemide, in particular of pure and stable form II
发明人：LUSSANA MASSIMILIANO; RAINONI MAURO; GAMBUZZA FILIPPO
权利人:COSMA S P A
摘要:The present invention relates to a new process for the synthesis of torsemide, in particular of pure and stable form II, which comprises direct synthesis of torsemide from 4-(3-methylphenylamino)-3-pyridine-sulphonamide. The new process envisages fewer steps than the processes described in the prior art, with improved yields and good quality from the chemical and preferably polymorphous points of view.

专利号:CA-2454037-A1
优先权日:2002-12-23
标题:A new process for the synthesis of torsemide, in particular of pure and stable form ii

专利号:EP-1433784-A1
优先权日:2002-12-23
标 题:Process for the synthesis of torsemide, in particular of pure and stable form II

专利号:US-6670478-B2
优先权日:2000-03-20
标题 :Process for preparing torsemide intermediate
发明人：KORDOVA MARCO
权利人:TEVA PHARMA
摘要:The present invention relates to new methods for the synthesis of torsemide and the torsemide synthetic intermediate, (3-sulfonylchloride-4-chloro)pyridine.