CAS: 117-80-6; Dichlone

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CAS号130-15-4 1,4-萘醌 | CAS号1010-60-2 2-氯-1,4-萘醌 | CAS号571-60-8 1,4-萘二酚 | CAS号1013-00-9 1,4-Naphthalene... | CAS号2395-97-3 9,10-Dimethoxya... | CAS号90-15-3 1-萘酚 | CAS号3669-52-1 4-乙酰基-1-萘酚 | CAS号64920-21-4 N-(4-hydroxynap... | CAS号84-86-6 4-氨基-1-萘磺酸 | CAS号2243-28-9 2,2,3,4,4-五氯-1,... | CAS号14422-77-6 1,4-Naphthalene... | CAS号22295-80-3 1,4-Naphthalene... | CAS号22359-32-6 2-chloro-3-(4-m... | CAS号64505-52-8 1,4-Naphthalene... | CAS号75112-57-1 2,5-dimethoxy-2... | CAS号100-10-7 对二甲氨基苯甲醛 | CAS号100-52-7 苯甲醛 | CAS号22295-47-2 1,4-Naphthalene... | CAS号22272-16-8 1,4-Naphthalene... | CAS号22272-27-1 1,4-Naphthalene...

1,4-萘醌置于碘,氯体系中,用 溶剂黄146 用作溶剂,化学反应生成2,3-二氯-1,4-萘醌
参考文献:外用非甾体类抗银屑病药物.1. 1,2,3,4-四氧化萘衍生物.
标题:外用非甾体类抗银屑病药物.1. 1,2,3,4-四氧化萘衍生物.
摘要:根据先前的观察结果,一系列的2,3-二氢-2,2,3,3-四羟基-1,4-萘醌(氧代磷酸酯,1)和6-氯异萘达沙林(2)在体内均显示出抗银屑病活性,制备了2种结构衍生物,并在scholtz-Dumas局部牛皮癣生物测定中进行了检查.在这六个(5,6,9A,10,11A,11B)中,发现最有效的化合物是6-氯-1,4-二乙酰氧基-2,3-二甲氧基萘(rs-43179,Lonapalene,11A).制备了广泛的1,2,3,4-四氧化萘(16-74),其中包含酯,醚和芳基取代基的变体,作为11A的类似物,以检查其活性的结构要求,并在体内筛选为抑制剂花生四烯酸引起的小鼠耳部水肿,是一种能够检测5-脂氧合酶抑制剂的局部生物测定法.净亲脂性,水解稳定性和环取代在确定观测到的体内活性中起重要作用.Lonapalene(11A)目前正在作为局部应用的非甾体类抗牛皮癣药物进行临床开发.
Doi:10.1021/jm00158A031

专利信息

专利号:US-2007196834-A1
优先权日:2005-09-09
标题:Method and system for the generation of large double stranded DNA fragments
发明人：CERRINA FRANCESCO; KAYSEN JAMES H; LI MO-HUANG; CHU LARRY L; BELSHAW PETER J; SUSSMAN MICHAEL R; RICHMOND KATHRYN
权利人:CERRINA FRANCESCO; KAYSEN JAMES H; LI MO-HUANG; CHU LARRY L; BELSHAW PETER J; SUSSMAN MICHAEL R; RICHMOND KATHRYN
摘要:Synthesis of long chain molecules such as DNA is carried out rapidly and efficiently to produce relatively large quantities of the desired product. The synthesis of an entire gene or multiple genes formed of many hundreds or thousands of base pairs can be accomplished rapidly and, if desired, in a fully automated process requiring minimal operator intervention, and in a matter of hours, a day or a few days rather than many days or weeks. Production of a desired gene or set of genes having a specified base pair sequence is initiated by analyzing the specified target sequence and determining an optimal set of subsequences of base pairs that can be assembled to form the desired final target sequence. The set of oligonucleotides are then synthesized utilizing automated oligonucleotide synthesis techniques. The synthesized oligonucleotides are subsequently selectively released from the substrate and used in a sequential assembly process.

专利号:US-6828347-B2
优先权日:2002-11-06
标题 :Anti-viral multi-quinone compounds and regiospecific synthesis thereof
发明人：STAGLIANO KENNETH WILLIAM; EMADI ASHKAN
权利人:ILLINOIS TECHNOLOGY INST
摘要:This invention provides various biquinone and trimeric quinone derivatives. The invention also provides a method for synthesis of a multi-quinone compound including reacting a hydroxyquinone anion with a first quinone possessing a first directing group at a C-2 of the first quinone and a second directing group at a C-3 of the first quinone and obtaining a biquinone having one of the first and second directing groups at a C-3 of a first quinone monomer and a hydroxyl group at a C-3′ of a second quinone monomer. The biquinone can be further reacted to obtain various biquinone derivatives or with a second hydroxyquinone anion to obtain trimeric quinone derivatives, including trimeric naphthoquinone derivatives. The biquinones and trimeric quinones of this invention demonstrate antiviral activity and can be used to treat viral infections, particularly HIV infections.

专利号:US-2009318592-A1
优先权日:2005-10-11
标 题 :Process for the Synthesis of Amine Ethers
发明人：FREY MARKUS; BROENNIMANN VALERIE
权利人:CIBA GEIGY CORP
摘要:The present invention relates to novel processes for the preparation of a sterically hindered amine ether by reacting a corresponding sterically hindered amine oxide with a ketone or an aldehyde with at least one reactive H in the presence of a peroxydisulphate. Products obtained by this process may be hydrogenated. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers.

专利号:US-7749300-B2
优先权日:2008-06-05
标题 :Photochemical synthesis of bimetallic core-shell nanoparticles
发明人：CHRETIEN MICHELLE N; WU YILIANG; CHOPRA NAVEEN
权利人:XEROX CORP
摘要:A method of forming bimetallic core-shell metal nanoparticles including a core of a first metal material and a shell of a second metal material, the method including photochemically producing metallic nanoparticle cores of the first metal material, and forming a shell of the second metal material around the cores. The shell can be formed by adding shell-forming precursor materials to a solution or suspension of the cores and photochemically forming the shells around the cores, or by separately photochemically producing metallic nanoparticles of the second metal material and mixing the metallic nanoparticles of the second metal material and the metallic nanoparticle cores to cause the metallic nanoparticles of the second metal material to form a shell around the metallic nanoparticle cores.

专利号:US-2007191516-A1
优先权日:2004-03-15
标题 :Process for the synthesis of amine ethers
发明人：FREY MARKUS; RAST VALERIE; BRAIG ADALBERT; KRAMER ANDREAS
权利人:FREY MARKUS; RAST VALERIE; BRAIG ADALBERT; KRAMER ANDREAS
摘要:A process for the preparation of a sterically hindered amine ether which comprises reacting a corresponding sterically hindered aminoxide with a C 5 -C 18 alk-1-ene in the presence of an organic hydroperoxide and optionally hydrogenating the resulting product as well as the product mixtures obtained therewith and their use as stabilizers and flame retardants.

专利号:US-8884051-B2
优先权日:2010-10-20
标题:Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent
发明人：MALOFSKY BERNARD M; MALOFSKY ADAM G; DEY TANMOY; SULLIVAN JEFFREY M; CHEN YANGBIN; WOJCIAK STANLEY C; COCKREM MICHAEL C
权利人:MALOFSKY BERNARD M; MALOFSKY ADAM G; DEY TANMOY; SULLIVAN JEFFREY M; CHEN YANGBIN; WOJCIAK STANLEY C; COCKREM MICHAEL C; BIOFORMIX INC
摘要:The present invention provides a method of making a methylene malonate monomer that includes the steps of reacting a malonic acid ester with a source of formaldehyde optionally in the presence of an acidic or basic catalyst and optionally in the presence of an acidic or non-acidic solvent to form reaction complex. The reaction is optionally performed in the presence of or contacted with an energy transfer means such as a heat transfer agent, a heat transfer surface, a source of radiation or a laser such that reaction complex is substantially vaporized to produce a vapor phase comprising methylene malonate monomer which may be isolated. The present invention further provides methylene malonate monomers prepared by the method of the invention, as well as compositions and products formed from the methylene malonate monomers, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).