CAS: 120-92-3; Cyclopentanone

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CAS号96-41-3 环戊醇 | CAS号98-00-0 糠醇 | CAS号98-01-1 糠醛 | CAS号2100-17-6 4-戊烯醛 | CAS号124-04-9 己二酸 | CAS号14320-37-7 3-环戊烯-1-酮 | CAS号930-30-3 2-环戊烯酮 | CAS号5459-00-7 环戊酮半卡腙 | CAS号142-29-0 环戊烯 | CAS号3078-07-7 cyclopentanone ... | CAS号1087-07-6 2,5-bis(thiophe... | CAS号10468-38-9 2-(3-bromopropy... | CAS号1120-70-3 1,1-二氟环戊烷 | CAS号109585-27-5 [1-(nitromethyl... | CAS号108994-73-6 5H-Cyclopenta[b... | CAS号10493-98-8 2-羟基-2-环戊烯-1-酮 | CAS号108106-97-4 2-OXO-2,5,6,7-T... | CAS号107535-40-0 1-(iodomethyl)c... | CAS号105064-92-4 2-[3-(benzenesu... | CAS号106115-44-0 2-(cyclohexylme...

环亮氨酸置于[1,6-Bis(2-Hydroxyphenyl)-2,5-Diaza-Hexa-1,5-Diene]Iron(III) Chloride,双氧水体系中,用 水,N,N-二甲基甲酰胺 用作溶剂,化学反应生成环戊酮
参考文献:非血红素铁催化剂对生物启发的氨基酸氧化
标题:非血红素铁催化剂对生物启发的氨基酸氧化
摘要:该研究报告了fe(III)催化的一系列一系列无环(α-氨基异丁酸,α-(甲基氨基)异丁酸,丙氨酸,正缬氨酸和2-氨基丁酸)的氧化脱羧和脱氨反应的动力学和机理. 1-氨基环丙烷-1-羧酸,1-氨基-1-环丁烷羧酸,1-氨基环戊烷羧酸和1-Aminocyclohexanecarboxylicacid),使用过氧化氢的氨基酸,吨丁基过氧化氢,亚碘酰苯,中号氯过苯甲酸,并peroxomonosulphate作为氧化剂在75%dmf-25%水溶剂混合物中.复合模型[fe Iv O(salen)] •+(salenh 2:N,N如先前报道,通过fe Iii(salen)cl和h 2 O 2在ch 3 Cn中于278 K的反应生成了'-双(水杨基亚乙基二胺).这种方法为我们提供了高价位的含氧铁离子,其稳定性足以确保直接观察与氨基酸的反应.
Doi:10.1016/j.Jinorgbio.2013.02.007

专利信息

专利号:US-11866398-B2
优先权日:2018-05-15
标 题:Total synthesis of prostaglandin J natural products by stereoretentive metathesis
发明人：LI JIAMING; CHEN XU; AHMED TONIA S; STOLTZ BRIAN M; GRUBBS ROBERT H
权利人:CALIFORNIA INST OF TECHN
摘要:This invention relates generally to the synthesis of Δ12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. Δ12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).

专利号:US-10995049-B2
优先权日:2019-07-19
标 题 :Total synthesis of prostaglandin J natural products and their intermediates
发明人：LI JIAMING; XU CHEN; AHMED TONIA S; GRUBBS ROBERT H; STOLTZ BRIAN M
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R 1 is defined in the specification

专利号:WO-2021035382-A1
优先权日:2019-08-23
标题:Method forcontinuous synthesis of 2-cyclopentene-1-one
发明人：HONG HAO; LU JIANGPING; BAO DENGHUI; YUAN LONG; WANG BO
权利人:LIAONING ASYMCHEM LABORATORIES CO LTD
摘要:Provided is a method for the continuous synthesis of 2-cyclopenten-1-one. The continuous synthesis method comprises: loading a catalyst in a continuous reaction device, then continuously conveying cyclopentene, an oxidant and a solvent into the continuous reaction device for an oxidation reaction, and continuously discharging 2-cyclopentene-1-one. In the presence of the catalyst and the solvent, cyclopentene is used as a starting material, and same is directly oxidized by the oxidant, which can avoid the generation of a large amount of halogen-containing three wastes; at the same time, the entire continuous synthesis process is carried out in the continuous reaction device, which can effectively inhibit the occurrence of safety risks during scale-up production; in addition, after the reaction is complete, the product system of the oxidation reaction can be simply concentrated to obtain the target product (2-cyclopenten-1-one). Thus, the purity (up to 98% and above) and separation rate (up to 79%) of the product are greatly improved, and production can be easily scaled up.

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-4910310-A
优先权日:1988-10-03
标 题:Synthesis of N-substituted 1,5-dideoxy-1,5-imino-L-fucitol derivatives
发明人：CAMPBELL ARTHUR L; BEHLING JAMES R; BABIAK KEVIN A; NG JOHN S; MUELLER RICHARD A; FLEET GEORGE W J
权利人:SEARLE & CO
摘要:Novel intermediates and method for the chemical synthesis of N-substituted 1,5-dideoxy-1,5-imino-L-fucitol derivatives are provided. A preferred intermediate is 1,5-dideoxy-1,5-imino-3, 4-O-isopropylidene-L-fucitol which is used to prepare the HIV inhibitor 1,5-dideoxy-1,5-imino-[N-ω-methyl caproate]-L-fucitol. These compounds are prepared in a short synthesis from the known compound 2,3-O-isopropylidene-D-lyxono-1,4-lactone or in a multi-step synthesis from D-galactose.

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.