CAS: 126-33-0; Tetrahydrothiophene 1,1-Dioxide

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17115-51-4 13031-76-0 872-93-5

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CAS号110-01-0 四氢噻吩(THT) | CAS号1600-44-8 四亚甲基亚砜 | CAS号110-52-1 1,4-二溴丁烷 | CAS号4724-56-5 1-methyl-4-[4-(... | CAS号17200-23-6 3-异丙氧基四氢噻吩1,1-二氧化物 | CAS号1192-16-1 2,3-二氢噻吩 1,1-二氧化物 | CAS号350-46-9 对氟硝基苯 | CAS号350-30-1 3-氯-4-氟硝基苯 | CAS号375-72-4 全氟丁基磺酰氟 | CAS号446-35-5 2,4-二氟硝基苯 | CAS号393-01-1 2,3,4-三氟三氟甲苯 | CAS号120770-03-8 2-氯-1,3-二氟-4-三氟甲苯 | CAS号21792-52-9 1,2-二乙炔基苯 | CAS号29866-60-2 2-Thiophenemeth... | CAS号880-78-4 5-氟硝基苯 | CAS号626-17-5 间苯二甲腈

四氢噻吩置于双氧水体系中,化学反应 0.42H,以90%的收率获得环丁砜
参考文献:Fe 3 O 4 / Peg-So 3 H作为非均相且可磁回收的纳米催化剂,用于将硫化物氧化为砜或亚砜
标题:Fe 3 O 4 / Peg-So 3 H作为非均相且可磁回收的纳米催化剂,用于将硫化物氧化为砜或亚砜
摘要:我们在下面介绍一种磺化-聚乙二醇涂层的fe 3 O 4纳米复合材料(fe 3 O 4 / Peg-So 3 H),它是一种非常有效的生态纳米催化剂,用于在溶剂中将硫化物选择性氧化为亚砜或砜,并具有出色的收率.游离条件,采用30%的过氧化氢作为氧化剂.在不改变所需特性的情况下,许多含有醇,酯和醛官能团的硫化物被有效地和选择性地氧化.磁性纳米催化剂(fe 3 O 4 / Peg-So 3H)可以通过使用外部磁性工具方便快捷地回收,并循环使用10多次以上,而不会显着降低其催化性能.
Doi:10.1039/c7Nj02513K

专利信息

专利号:US-8350031-B2
优先权日:2008-06-02
标 题:Processes for the synthesis of levocetirizine and intermediates for use therein
发明人：RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
权利人:CIPLA LTD; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
摘要:The present invention provides a compound of formula (IV) n nwherein R is Cl, Br, NO 2 , OH or OR′, and R′ is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (−)-1-[(4-chlorophenyl)-phenylmethyl]piperazine, an intermediate useful in the synthesis of levocetirizine. The present invention also provides compounds (II) and (III) which are useful in the synthesis of compound (IV).

专利号:US-2024287520-A1
优先权日:2021-06-30
标题:Method for synthesis of linkage modified oligomeric compounds
发明人：RODRIGUEZ ANDREW A
权利人:IONIS PHARMACEUTICALS INC
摘要:The present disclosure provides methods of synthesizing modified oligonucletodies and oligomeric compounds (including oligomeric compounds that are antisense agents or portions thereof) comprising a modified oligonucleotide having at least one modified internucleoside linking group. In certain embodiments, the present disclosure provides stabilized formulations of certain sulfonyl azides for use in the synthesis of olignonucleotides comprising one or more sulfonyl phosphoramidate linkages. Some embodiments provide stabilized compositions of high energy reagents that may be used in the synthesis of modified oligonucleotides, allowing for safe process scale preparation thereof.

专利号:US-11434211-B2
优先权日:2020-06-16
标题:Synthesis of 5-nitrotetrazole
发明人：PIERCEY DAVIN GLENN; MANSHIP TIMOTHY D; SMITH DAWSON MICHAEL
权利人:PURDUE RESEARCH FOUNDATION
摘要:This disclosure shows the ability of a readily-available oxidizer to achieve oxidation of 5-amino-1H-tetrazole (5-AT) to 5-nitrotetrazole (5-NT) in high yields in a single pot synthesis. This strategy reduces the synthesis of this important energetic material down to a single step and eliminates highly sensitive diazonium and copper salt primary explosive intermediates. The overall yield of this process is 48-53% and the resultant aqueous solution of product effectively used for the preparation of nitrotetrazole-containing primary explosive DBX-1. Unlike current methods of nitrotetrazole preparation, the novel method is entirely solution-based and prepares a final solution of sodium nitrotetrazolate, never once needing to handle energetic intermediates or products, making it a much safer method of nitrotetrazole preparation.

专利号:US-5442065-A
优先权日:1993-09-09
标 题:Synthesis of tetrahydroquinoline enediyne core analogs of dynemicin
发明人：MAGNUS PHILIP D; ILIADIS THEODORE; EISENBEIS SHANE A; FAIRHURST ROBIN A
权利人:UNIV TEXAS
摘要:A process is described for the preparation of the core azobicyclo[7.3.1]tridecaenediyne moiety of the antitumor antibiotic dynemicin. The synthesis allows efficient production of the enediyne as a stable, compound in good yield from the adamantyl N-protected azabicyclo[7.3.1]tridecadiyne. The adamantyl protecting group is employed in the starting material, N-adamantyl dihydroquinoline or N-adamantyl 6-methoxy quinoline. Also disclosed are process for the synthesis of 3-hydroxy-6-methoxyquinoline and several N-substituted derivatives of azobicyclo[7.3.1]tridecaenediyne. Solid tumor and leukemia assays were performed on the analogs of dynemicin. The results suggest a method that these compounds will useful in treating certain types of leukemias and solid tumors. The disclosed synthesis provides a route to new dynemicin intermediates and analogs which will allow development of second and third generation dynemicins.

专利号:WO-2013091696-A1
优先权日:2011-12-21
标题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:LEK PHARMACEUTICALS; HUMLJAN JAN; MARAS NENAD
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-4347379-A
优先权日:1980-03-10
标 题:Synthesis of alpha-alkoxycarboxylic acids
发明人：LAI JOHN T
权利人:GOODRICH CO B F
摘要:Numerous alpha-carboxylic acids are prepared in a liquid medium by the reaction of an organic compound having at least one reactive hydroxyl or thiol group, with a monoketone, and a haloform, in the presence of a phase transfer catalyst and an alkali metal hydroxide. The term 'alpha-alkoxycarboxylic acids' includes alpha-phenoxycarboxylic acids, alpha-thioalkoxycarboxylic acids and alpha-thiophenoxycarboxylic acids. Specific substituents on the beta carbon atom of an alpha-alkoxycarboxylic (or '2-alkoxycarboxylic') acid reaction product formed in this novel synthesis, are introduced by appropriate choice of the ketone reactant; alkoxy and phenoxy substituents on the alpha carbon atom of a 2-alkoxycarboxylic acid are introduced by appropriate choice of the organic compound having a hydroxyl or thiol group. De-alkoxylation of the 2-alkoxycarboxylic acid yields alpha-beta monoolefinically unsaturated carboxylic acids which are necessarily alpha substituted, and may also be beta-substituted. It is now possible to produce, simply and conveniently, numerous substituted alpha-beta monolefinically unsaturated carboxylic acids with a variety of substituents on the alpha carbon atom, and, optionally on the beta carbon atom of these substituted carboxylic acids. Esters may also be conventionally derived from both the 2-alkoxycarboxylic acids, and the unsaturated carboxylic acids. During the phase transfer catalyzed synthesis of this invention, an intermediate acyl halide derivative is formed prior to the formation of the 2-alkoxycarboxylic acid reaction product. The formation of the acyl halide derivative allows the subsequent direct formation, in a modification of the same reaction, of 2-alkoxycarboxylic acid amides (or '2-alkoxycarbamides'), simply by adding a primary or secondary amine to the reaction mass. By dealkoxylation of the 2-alkoxycarbamides, specific, necessarily alpha-substituted and optionally beta-substituted acrylamides are synthesized which previously could be prepared, if at all, only with difficulty.