合成目标产物 Iron Hydroxide 主要起始原料 Ethanamine, N-[(3,5-Dichlorophenyl)Methylene]-2,2-Diethoxy- And Iron
(文献来源)合成步骤主要原料 Ethanamine, N-[(3,5-Dichlorophenyl)Methylene]-2,2-Diethoxy- 和 Iron
Ferric Nitrate 反应生成氢氧化铁 参考文献:Edwards,Marc;Benjamin,Mark M.,Res. J. Water Pollut. Contr. Fed,61,(1989) N,C. 1523-1533 标题:Edwards,Marc;Benjamin,Mark M.,Res. J. Water Pollut. Contr. Fed,61,(1989) N,C. 1523-1533
专利信息
专利号:US-9011694-B2 优先权日:2010-09-28 标 题 :Method for the synthesis of tetravalent manganese feroxyhite for arsenic removal from water 发明人:MITRAKAS MANASSIS; SYMEONIDIS KONSTANTINOS; TRESINTSI SOFIA 权利人:MITRAKAS MANASSIS; SYMEONIDIS KONSTANTINOS; TRESINTSI SOFIA; LOUFAKIS CHEMICALS S A 摘要:The present invention refers to a method for the synthesis of an adsorbing material consisting of a single-phase tetravalent manganese feroxyhite (Å?-Fe (1-x) Mn x OOH), in which a percentage of 0.05 to 25% of iron atoms has been isomorphically substituted by Mn(IV) atoms. Its production takes place in a continuous two-stage flow reactor at weakly acidic conditions (pH 4-7) and high redox (300-800 mV). The material can be used for the removal of both pentavalent and trivalent arsenic as well as other heavy metals form water. More specifically, its adsorption capacity and selectivity depending on the trivalent and pentavalent arsenic water content, are determined by the manganese percentage and the compact or hollow morphology of its structural unit which can be both controlled by the parameters of the synthesis procedure.
专利号:WO-2012001578-A1 优先权日:2010-06-29 标 题 :Single-step synthesis of iron oxide nanoparticles 发明人:BURDINSKI DIRK; HAEX NICOLE PETRONELLA MARTIEN 权利人:KONINKL PHILIPS ELECTRONICS NV; BURDINSKI DIRK; HAEX NICOLE PETRONELLA MARTIEN 摘要:The invention provides methods for the synthesis of iron oxide nanoparticles and the particles obtainable by these methods. The particles can be used as tracer materials for magnetic particle imaging and for Magnetic Particle Spectroscopy (MPS). The method for the synthesis of these particles comprises the steps: (i) dissolving at least one water-soluble iron salt and at least one water-soluble stabilizer in water to form a reaction batch, (ii) adding at least one base to the reaction batch to yield a pH of 10 to 13, and (iii) exposing the reaction batch to a reaction temperature T R for a defined period of time DT, wherein T R ≥ 110°C, to obtain the iron oxide nanoparticles.
专利号:US-7759520-B2 优先权日:1996-11-27 标 题 :Synthesis of selective androgen receptor modulators 发明人:DALTON JAMES T; MILLER DUANE D; YIN DONGHUA; HE YALI 权利人:UNIV TENNESSEE RES FOUNDATION 摘要:The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas. The process of the present invention is suitable for large-scale preparation, since all of the steps give rise to highly pure compounds, thus avoiding complicated purification procedures which ultimately lower the yield. Thus the present invention provides methods for the synthesis of non-steroidal agonist compounds, that can be used for industrial large-scale synthesis, and that provide highly pure products in high yield.
专利号:US-6995284-B2 优先权日:2000-08-24 标题 :Synthesis of selective androgen receptor modulators 发明人:DALTON JAMES T; MILLER DUANE D; HE YALI; YIN DONGHUA 权利人:UNIV TENNESSEE RES FOUNDATION 摘要:The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) which are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas. The process of the present invention is suitable for large-scale preparation, since all of the steps give rise to highly pure compounds, thus avoiding complicated purification procedures which ultimately lower the yield. Thus the present invention provides methods for the synthesis of non-steroidal agonist compounds, that can be used for industrial large-scale synthesis, and that provide highly pure products in high yield.
专利号:US-2023286918-A1 优先权日:2020-07-02 标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat 发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER 权利人:AKEBIA THERAPEUTICS INC 摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
专利号:US-10925977-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications 发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S 权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS 摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
摘要:MOWRY RW. Improved procedure for the staining of acidic polysaccharides by Müller's colloidal (hydrous) ferric oxide and its combination with the Feulgen and the periodic acid-Schiff reactions. Lab Invest. 1958 Nov;7(6):566–76. 参考文献:10.1093/ndt/gfl289 摘要:Savica V, Calò LA, Monardo P, Santoro D, Bellinghieri G. Phosphate binders and management of hyperphosphataemia in end-stage renal disease. Nephrol Dial Transplant. 2006 Aug;21(8):2065–8. doi: 10.1093/ndt/gfl289. 参考文献:10.1021/es071553d 摘要:Zeng H, Fisher B, Giammar DE. Individual and competitive adsorption of arsenate and phosphate to a high-surface-area iron oxide-based sorbent. Environ Sci Technol. 2008 Jan 01;42(1):147–52. doi: 10.1021/es071553d. 参考文献:10.1021/jacs.9b03329 摘要:Yadav V, Gordon JB, Siegler MA, Goldberg DP. Dioxygen-Derived Nonheme Mononuclear FeIII(OH) Complex and Its Reactivity with Carbon Radicals. J. Am. Chem. Soc. 2019 Jun 20;141(26):10148–53. doi: 10.1021/jacs.9b03329. 参考文献:10.1128/aem.50.6.1502-1504.1985 摘要:Farrah SR, Preston DR. Concentration of viruses from water by using cellulose filters modified by in situ precipitation of ferric and aluminum hydroxides. Appl Environ Microbiol. 1985 Dec;50(6):1502–4. doi: 10.1128/aem.50.6.1502-1504.1985.