CAS: 135-62-6; 3-Hydroxy-N-(2-Methoxyphenyl)-2-Naphthamide

上下游产品

2-methoxy-phenylamine 3-Hydroxy-2-naphthoic acid 1-isothi°Cyanato-2-methoxybenzene 2-amino-phenolb;2',3'-d]furan-6-carboxylic acid o-anisidide8,13-dioxo-8,13-dihydro-dinaphtho[2,1-b;2',3'-d]furan-6-carboxylic acid o-anisidide 3-hydroxy-4-(3-nitro-phenylazo)-[2]naphthoic acid-(5-chloromethyl-2-methoxy-anilide) 1-(2',5'-dichlorophenylazo)-2-hydroxy-3-naphthanilide e][1,3]oxazin-4-one2-imino-3-(2-methoxy-phenyl)-2,3-dihydro-naphtho[2,3-e][1,3]oxazin-4-one

2-氨基苯酚置于sodium Hydride,三氯氧磷体系中,用 氯苯,乙腈 用作溶剂,化学反应 24.25H,反应生成3-羟基-N-(2-甲氧基苯基)-2-萘甲酰胺
参考文献:N-烷氧基苯基羟基萘羧酰胺的亲水性研究†.
标题:N-烷氧基苯基羟基萘羧酰胺的亲水性研究†.
摘要:对于admet量身定制的结构活性模型的合理设计,评估生物活性剂的亲脂特性是必不可少的.N-烷氧基-3-羟基萘-2-甲酰苯胺,N-烷氧基-1-羟基萘-2-甲酰苯胺和n-烷氧基-2-羟基萘-1-甲酰苯胺最近被报道为一系列具有抗分枝杆菌,抗菌素和除草活性.由于发现这些生物活性剂的亲脂性决定了它们的活性,因此在本研究中对这三个系列的亲脂性进行了研究.使用反相高效液相色谱法分析所有57种苯胺类化合物的亲脂性.该过程是在等度条件下,使用封端的非极性c18固定反相色谱柱在甲醇中作为流动相的有机改性剂进行的.在本研究中,使用了一系列亲脂性预测软件来估算一组n-烷氧基苯基羟基萘甲酰胺的clogp值,随后与实验参数进行了交叉比较.因此,将亲脂性(logk)和分布参数(π)的经验值与使用推论亲脂性特征的替代方法计算出的相应计算机特性进行了比较.为了研究衍生物之间的(不相似)相似性,采用了pca程序以可视化方式观察分子在亲脂性方面的主要性能差异,
Doi:10.3390/molecules23071635

专利信息

专利号:US-4118384-A
优先权日:1976-02-21
标题 :Process for preparation of azo dyestuffs by coupling in presence of aromatic sulphonic acid-formaldehyde reaction product
发明人：MOLLS HANS-HEINZ; SCHIWY WILLY; HORNLE REINHOLD; NEBELING REINHARD
权利人:BAYER AG
摘要:Dyestuff dispersions and dyestuff solutions free from salt or at least having a low salt content are obtained in that the diazotization is carried out with addition of free dispersing agent acid to which, after the synthesis, either no basic agents are added or basic agents are added only up to a pH value of 3. The disclosed process gives dyestuff compositions of low salt content and results in readily dispersible dyestuffs when water insoluble dyestuffs are prepared and stable solutions when water soluble dyestuffs are prepared. The process is widely applicable and chemical constitution of the dyestuffs is conventional.

专利号:DE-2606905-A1
优先权日:1976-02-20
标 题:PROCESS FOR PUMP COLORING OR PRINTING OF MATERIALS MADE OF SYNTHESIS FIBERS AND THEIR MIXTURES WITH CELLULOSE FIBERS