CAS: 19764-30-8; Ac-D-Leu-Oh

相似化合物

99-15-0 1188-21-2 1114-55-2

上下游产品

methyl N-acetyl-leucinate N-acetylleucine 2-acetylamino-4-methyl-pent-2-enoic acid (Z)-2-Acetylamino-4-methyl-pent-2-enoic acid(R)-leucine (R)-2-Acetylamino-4-methyl-pentanoic acid ((R)-3-benzyl-1-benzyloxy-2,5-dioxo-pyrrolidin-3-yl)-amide (R)-2-Acetylamino-4-methyl-pentanoic acid ((S)-3-benzyl-1-benzyloxy-2,5-dioxo-pyrrolidin-3-yl)-amide (+)-(3R)-3-(N-acetyl-D-leucylamino)-3-benzyl-1-hydroxysuccinimide

Fmoc-D-亮氨酸置于哌啶体系中,用 四氢呋喃,水,N,N-二甲基甲酰胺 用作溶剂,化学反应生成N-乙酰基-D-亮氨酸
参考文献:单步荧光探针可通过分子内反应检测hdac的巴豆酰化活性
标题:单步荧光探针可通过分子内反应检测hdac的巴豆酰化活性
摘要:赖氨酸巴豆酰化在基因转录和细胞代谢中起着至关重要的作用.然而,剖析巴豆缩醛化的分子机理的方法仍然是有限的.到目前为止,还没有开发用于酶促巴豆酰化活性检测的单步荧光方法.主要的困难是脂族巴豆酰化赖氨酸不允许π与荧光团结合,而巴豆酰化不能直接调节电子态.本文中,我们设计并合成了两种基于活性的单步荧光探针ktcr-I和ktcr-Ii用于检测酶促巴豆酰化活性.这两个探针可以被组蛋白脱乙酰基酶识别,并经历分子内亲核交换反应以产生荧光信号.值得注意的是,观测到肽序列依赖性作用.Sirt2可以更有效地识别ktcr-I,而ktcr-Ii具有lgkcr肽序列的人优先与hdac3反应.与其他研究酶促巴豆酰化活性的方法相比,我们的单步荧光方法具有许多优点,例如,操作简便,灵敏度高,设备便宜且消耗的材料少.我们预想,在这项研究中开发的探针将提供有用的工具来筛选抑制hdac的巴豆酰化活性的抑制剂.这样的探针将用于进
Doi:10.1016/j.Ejmech.2020.113120

专利信息

专利号:US-2011245503-A1
优先权日:2008-11-28
标题 :Enantioselective synthesis of asymmetric beta-carboline intermediates
发明人：SANTOS LEONARDO; ESPINOZA MORAGA MARLENE; SHANKARAJAH NAGULA
权利人:UNIV TALCA
摘要:Described herein is a new asymmetric synthesis of imines to obtain β-carboline derivatives useful as key intermediate compounds for the synthesis of phosphodiesterase inhibitors using a new process with palladium or ruthenium hydride and/or nickel boride to reduce chiral intermediates. The use of chloroformate chiral auxiliaries is further described for the reduction and asymmetric hydrogenation of imines to obtain β-carboline derivatives and intermediate compounds used in the preparation thereof.

专利号:US-4985567-A
优先权日:1988-03-07
标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
发明人：ACHIWA KAZUO; TAKEDA HIDEO
权利人:KAZUO ACHIWA; FUJI YAKUHIN KOGYO KK
摘要:New chiral phosphinopyrrolidine compounds of the general formula: ##STR1## wherein R 1 is hydrogen or --COA 1 , --COOA 2 , --CONHA 3 , --SO 2 A 4 or --PO(A 5 ) 2 , A 1 , A 2 , A 3 , A 4 and A 5 each represents independently alkyl or aryl, R 2 is phenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, and R 3 is phenyl, lower-alkylphenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, with the proviso that R 2 and R 3 may not simultaneously by phenyl, p-di(lower-alkyl)-aminophenyl or p-lower-alkoxyphenyl, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

专利号:US-2007015798-A1
优先权日:2005-02-25
标 题 :Efficient and stereoselective process for large scale synthesis of (3R)-3-(2,3-dihydrobenzofuran-5-yl)-1,2,3,4-tetrahydropyrrolo[3,4-b]quinolin-9-one derivatives
发明人：LI XUN; LEMAIRE SEBASTIEN; MARKO ISTVAN; WILLEMSENS ALBERT
权利人:LI XUN; LEMAIRE SEBASTIEN; MARKO ISTVAN; WILLEMSENS ALBERT
摘要:This invention relates to an efficient process for large scale stereoselective production of (3R)-3-(2,3-dihydrobenzofuran-5-yl)-1,2,3,4-tetrahydropyrrolo[3,4-b]quinolin-9-ones and key intermediates used for the preparation of benzofuranyl pyrroloquinolones as potent and selective PDE5 inhibitors for the treatment of erectile dysfunction, as well as pharmaceutical compositions and methods of treatment utilizing these compounds.

专利号:EP-1851227-A1
优先权日:2005-02-25
标题 :An efficient and stereoselective process for large scale synthesis of 3-(r)-3- (2,3-dihydrobenzofuran-5-yl)-1,2,3,4- tetrahydropyrrolo{3,4-b}quinolin-9-one

专利号:CN-111440121-A
优先权日:2020-03-26
标 题 :A method for the separation of two key intermediates in the total synthesis of optically pure tetrandrine

专利号:CN-111440121-B
优先权日:2020-03-26
标 题 :A method for splitting two key intermediates in the total synthesis of optically pure tetrandrine