CAS: 245765-41-7; 1-Cyclopropyl-8-Methyl-7-(5-Methyl-6-(Methylamino)Pyridin-3-yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid

上下游产品

ethyl 7-chloro-1-cyclopropyl-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate 30H29N3O4C30H29N3O4 2,5-dibromo-3-methylpyridine (5-bromo-6-methylpyridin-2-yl)methylamine

2,5-二溴-3-甲基吡啶置于(1,1'-Bis(Diphenylphosphino)Ferrocene)Palladium(II) Dichloride,Potassium Tert-Butylate,Potassium Acetate,碳酸氢钠,三乙胺,Sodium Hydroxide体系中,用 1,4-二氧六环,水,N,N-二甲基甲酰胺,甲苯 用作溶剂,化学反应 22.83H,反应生成奥泽沙星
参考文献:一种奥泽沙星及其中间体的制备方法
标题:一种奥泽沙星及其中间体的制备方法
摘要:本发明提供了一种以下通式(ⅲb)所表示的化合物及其制备方法,也提供了所述通式(ⅲb)的化合物作为关键中间体用于制备奥泽沙星的用途:

专利信息

专利号:US-12252473-B2
优先权日:2022-04-18
标 题:Preparation methods of quinolone compounds and intermediates thereof
发明人：LEI JIE; CHEN ZHONGZHU; XU ZHIGANG; TANG DIANYONG; XU JIAYU; ZHOU HAOYI; XIA DANDAN; LIU YAO; CAO YIHUA; LUO JIE
权利人:UNIV CHONGQING ARTS & SCIENCES
摘要:The present application relates to processes for the preparation of quinolone compounds and intermediates thereof, particularly to processes for the preparation of quinolones and pharmaceutical intermediates of the quinolones. In particular, the present application provides a process for the preparation of a compound of Formula I, and a process for the synthesis of quinolone compounds using the compound of Formula I as an intermediate. The process for the preparation of the compound of Formula I comprises the steps of:reacting a compound of Formula A with R5NH2 and R6Cl in the presence of a base to form the compound of Formula I,

专利号:CN-107304198-A
优先权日:2016-04-19
标 题:A new synthesis process of quinolone antibiotic intermediate

专利号:CN-107304198-B
优先权日:2016-04-19
标题 :Novel synthesis process of quinolone antibiotic intermediate