N,N-二甲基甲酰胺置于lithium Diisopropyl Amide体系中,用 四氢呋喃 用作溶剂,化学反应 1.91H,以95%的收率获得2-溴-6-氟苯甲醛 参考文献:Process For The Preparation Of Indazolyl Ureas That Inhibit Vanilloid Subtype1 (Vr1) Receptors 标题:Process For The Preparation Of Indazolyl Ureas That Inhibit Vanilloid Subtype1 (Vr1) Receptors 摘要:本发明涉及一种制备对vanilloid受体亚型1(vr1)具有拮抗作用的吲唑基脲类化合物的方法.
专利号:US-8338451-B2 优先权日:2008-03-21 标 题 :Polysubstituted derivatives of 2-heteroaryl-6-phenylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof 发明人:DE PERETTI DANIELLE; EVANNO YANNICK; LARDENOIS PATRICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; ALMARIO GARCIA ANTONIO 权利人:DE PERETTI DANIELLE; EVANNO YANNICK; LARDENOIS PATRICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; ALMARIO GARCIA ANTONIO; SANOFI SA 摘要:Compounds of formula (I): n nwherein R, R 1 , R 2 , R 3 , R 4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
专利号:US-8148370-B2 优先权日:2008-03-21 标题 :Polysubstituted derivatives of 2-aryl-6-phenyl-imidazo[1,2-a]pyridines, and preparation and therapeutic use thereof 发明人:DE PERETTI DANIELLE; EVANNO YANNICK 权利人:DE PERETTI DANIELLE; EVANNO YANNICK; SANOFI AVENTIS 摘要:Compounds of formula (I): n nwherein R 1 , R 2 , R 3 , R 4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
专利号:CN-113264819-A 优先权日:2021-05-25 标题 :A kind of method for rapid synthesis of 3-bromo-2-fluorobenzaldehyde based on continuous flow reaction technology
专利号:US-11801251-B2 优先权日:2015-11-03 标 题 :Selective HDAC8 inhibitors and their uses 发明人:MEYER-ALMES FRANZ-JOSEF; MEYNERS CHRISTIAN; KLEINSCHEK ALEXANDER; HAUS PATRICIA 权利人:HOCHSCHULE DARMSTADT 摘要:The present invention relates to small molecule compounds based on benzopyrimido- or benzoimidazo-thiazin-imine as well as their (synthesis) intermediates and their use as HDAC inhibitors, in particular HDAC8 inhibitors. The present invention also relates to the use of said compounds in the treatment of cancer and as therapeutic agents for eukaryotic parasites and respective methods of treatment.