CAS: 37248-47-8; (2R,3R,4S,5S,6R)-2-(((1R,2R,3S,4S,6R)-2,3-Dihydroxy-6-(Hydroxymethyl)-4-(((1S,4R,5S,6S)-4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-yl)Amino)Cyclohexyl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol

该化合物是一种自然产生的抗生素和杀真菌剂,主要来自对细菌的发酵,其特点是其复杂的结构,包括糖碱和环球浸泡物成分,有助于其生物活动; Valymycin A具有很强的抗风素特性,特别是针对各种植物病原体,使其在农业作物保护应用中具有价值; 其行动机制包括抑制真菌细胞壁中的焦素合成,这对于其生长和生存至关重要; 此外,已经研究过Valyycin A在控制某些细菌感染和作为生物杀虫剂方面的潜在用途,因为它对非目标生物生物毒性低; 该化合物在各种环境条件下可溶于水和表面稳定,从而增强其在农业配方中的效用. 总之,Valymycin A是发展环境友好害虫害控制剂方面的一大进步.

结构式图片

物理性质

欧盟法规

C&L通报REACH预注册

上下游产品

CAS号2280-44-6 D-glucopyranose | CAS号86733-63-3 7,2'',3'',4'',6... | CAS号114779-32-7 1D-(1,3,6/2)-6-... | CAS号114779-35-0 (1R,2S,5R,7R,8R... | CAS号86733-61-1 2,3,4',5',6',7'... | CAS号86733-62-2 7-O-acetyl-2,3,... | CAS号86756-42-5 (4aR,6S,7S,8S,8... | CAS号38665-10-0 4-(Hydroxymethy... | CAS号32780-32-8 布兰美肽 | CAS号38231-86-6 井冈霉烯胺盐酸盐 | CAS号102583-47-1 (2S,3R,4R,5S,6S...

合成工艺路线路线简述

    2,3,4',5',6',7'-Hexa-O-Benzyl-4,7-O-Benzylidene-6-P-Toluenesulphenylvalidoxylamine A置于ranei Nickel T-4 咪唑,氨,氢气,Silver Trifluoromethanesulfonate,Sodium,溶剂黄146,1,1,3,3-四甲基脲体系中,用 四氢呋喃,1,4-二氧六环,乙醇,二氯甲烷,氯仿 作为反应溶剂,化学反应 79.0H,反应生成 井冈霉素
    参考文献:Miyamoto,Yasunobu; Ogawa,Seiichiro,Journal Of The Chemical Society. Perkin Transactions I,1989,# 5,P. 1013-1018
    标题:Miyamoto,Yasunobu; Ogawa,Seiichiro,Journal Of The Chemical Society. Perkin Transactions I,1989,# 5,P. 1013-1018

    海关参考信息

    专利信息


    专利号:US-2016073631-A1
    优先权日:2013-03-04
    标 题 :Process for the preparation of dihydropyrrole derivatives
    发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
    权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
    摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

    专利号:US-9968097-B2
    优先权日:2012-05-30
    标题:Composition comprising a biological control agent and a fungicide selected from inhibitors of the lipid membrane synthesis, the melanine biosynthesis, the nucleic acid synthesis or the signal transduction
    发明人:WACHENDORFF-NEUMANN ULRIKE; ANDERSCH WOLFRAM; STENZEL KLAUS; SPRINGER BERND
    权利人:BAYER CROPSCIENCE AG
    摘要:The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.

    专利号:US-2011230343-A1
    优先权日:2008-10-24
    标题 :Method for the Manufacture of Microparticles Comprising an Effect Substance
    发明人:SCHROERS MICHAEL; DYLLICK-BRENZINGER RAINER; MERK MICHAEL; BARG HEIKO
    权利人:BASF SE
    摘要:A subject matter of the present invention is a process for the preparation of effect compound-comprising microparticles M comprising A) the formation of a crude suspension of microparticles A by means of enzymatic polyester synthesis in an inverse miniemulsion comprising enzyme, effect compound and polyester monomers; and B) the polymerization of wall monomers from the group consisting of ethylenically unsaturated monomers, polyisocyanates and polyepoxides in the crude suspension of microparticles A. Furthermore, the present invention relates to microparticles M which can be obtained by means of the process according to the invention and also to an agrochemical formulation comprising microparticles M. In addition, the present invention relates to the use of microparticles M prepared according to the invention as component in colorants, cosmetics, drugs, biocides, plant protection agents, fertilizers, additives for food or animal fodder, or auxiliaries for polymers, paper, textiles, leather, detergents or cleaners. Finally, the invention also relates to a method for combating undesirable plant growth, to a method for combating undesirable insect or acarid infestation on plants and/or for combating phytopathogenic fungi, and to seeds treated with the agrochemical formulation.

    专利号:RU-2129788-C1
    优先权日:1995-01-20
    标题:Method of suppression of phytopathogen fungi, derivative of benzophenone, a method of protection of plants from damage caused by phytopathogen fungus, a fungicide composition, methods of synthesis of benzophenones

    专利号:US-9706777-B2
    优先权日:2012-05-30
    标题:Composition comprising a biological control agent and a fungicide selected from inhibitors of amino acid or protein biosynthesis, inhibitors of ATP production and inhibitors of the cell wall synthesis
    发明人:WACHENDORFF-NEUMANN ULRIKE; ANDERSCH WOLFRAM; STENZEL KLAUS; SPRINGER BERND
    权利人:BAYER CROPSCIENCE AG
    摘要:The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.

    专利号:US-5684026-A
    优先权日:1994-11-22
    标 题:Aminocyclopentane derivative
    发明人:OGAWA SEIICHIRO; UCHIDA CHIKARA; KIMURA HIROSHI; INOKUCHI JIN-ICHI
    权利人:SEIKAGAKU KOGYO CO LTD
    摘要:The present invention provides aminocyclopentane derivatives which are saccharide analogs having extremely high alpha -glucosidase inhibitory effects and novel structures and expected to be usable or applicable to drugs or agricultural chemicals. An aminocyclopentane derivative represented by the formula (1), wherein R1 represents H while R2 represents CH2OH, or R1 represents CH2OH while R2 represents H and R3 represents a substituted or unsubstituted aryl group or an alkyl, alkenyl, alkynyl or hydroxyalkyl group having 1 to 10 carbon atoms, intermediates for the synthesis of the same, a process for producing the intermediates and a process for producing the aminocyclopentane derivative.
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    主要参考文献


    1: Liu Y, Yang F, Wan S, Wang X, Guan L, Li Y, Xu C, Xie B, Wang S, Tan XL, Tang B. Comparative transcriptomic and metabolomics analysis of ovary in Nilaparvata lugens after trehalase inhibition. BMC Genomics. 2025 Feb 1;26(1):98. doi: 10.1186/s12864-025-11268-8.
    2: Zhang H, Li H, Fang S, Guan D, Wei J, Wang Z, Luo Z, Qian K, Wang J. Co- application of Validamycin A and dsRNAs targeting trehalase genes conferred enhanced insecticidal activity against Laodelphax striatellus. Pestic Biochem Physiol. 2024 Nov;205:106160. doi: 10.1016/j.pestbp.2024.106160. Epub 2024 Oct 3. 81(2):903-911. doi: 10.1002/ps.8492. Epub 2024 Oct 22. 13(19):2743. doi: 10.3390/plants13192743.
    5: Ogunnupebi TA, Oduselu GO, Elebiju OF, Ajani OO, Adebiyi E. In silico studies of benzothiazole derivatives as potential inhibitors of Anopheles funestus and Anopheles gambiae trehalase. Front Bioinform. 2024 Aug 9;4:1428539. doi: 10.3389/fbinf.2024.1428539.

    合成参考文献


    摘要:Japan Pesticide Information., (40)(32), 1982
    摘要:Worthing, C.R. and S.B. Walker (eds.). The Pesticide Manual - A World Compendium. 8th ed. Thornton Heath, UK: The British Crop Protection Council, 1987., p. 836
    摘要:Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. V9 866 (1980)
    摘要:Farm Chemicals Handbook 1992. Willoughby, OH: Meister Publishing Co., 1992., p. C355
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