CAS: 42989-85-5; Boc-Aoa-Oh

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号2921-14-4 羧甲氧基胺半盐酸盐 | CAS号36016-38-3 N-叔丁氧羰基羟胺 | CAS号79-08-3 溴乙酸 | CAS号136499-22-4 Acetic acid, [[... | CAS号80366-85-4 B°C-NH-O-C1-NHS...

N-羟基氨基甲酸叔丁酯置于n,N-二异丙基乙胺,Lithium Hydroxide体系中,用 四氢呋喃,二氯甲烷,水 作为反应溶剂,化学反应 18.0H,反应生成 叔丁氧羰基氨氧基乙酸
参考文献:扩展的环状酮肟肟六肽的合成和构象分析.
标题:扩展的环状酮肟肟六肽的合成和构象分析.
摘要:在这项工作中,描述了在n端具有羟胺官能团的线性六肽的合成,在c端具有酮而不是羧酸的合成.通过酮肟形成的环化反应产生19元环扩展的环六肽环[goly-Val-Ala-Pro-Leu-Kly],该环采用具有两个分子内氢键的主要构象体.酮肟的水解稳定性介于惰性酰胺和不稳定的亚胺之间.用酰胺键取代亚胺键可将不可逆的大环化转变为可逆的过程,但是大环亚胺很难分离,因为它们易于水解.酮肟的增强的化学稳定性证明其在连接方案中的应用是正确的.此处介绍的酮肟键的详细NMR分析确定了在受限肽环境中其局部构象偏好.版权所有©2016欧洲多肽协会和john Wiley&sons,Ltd.
DOI:10.1002/psc.2873

专利信息

专利号:US-8415510-B2
优先权日:2008-02-28
标题 :Synthesis of a PEG-6 moiety from commercial low-cost chemicals
发明人：ENGELL TORGRIM
权利人:ENGELL TORGRIM; GE HEALTHCARE LTD
摘要:The present invention provides novel synthesis's for obtaining a protecting group aminoxy PEG-6 linker from cost effective, and readily available starting materials and chemicals or modified polyethylene glycols. More specifically, a novel synthesis of obtaining a modified Boc-protected aminoxy PEG-6 linker was achieved so that said linker may be attached to a vector such as a peptide based fragment.

专利号:US-8536375-B2
优先权日:2008-12-22
标题:Synthesis of obtaining modified polyethylene glycol intermediates
发明人：ENGELL TORGRIM
权利人:ENGELL TORGRIM; GE HEALTHCARE LTD
摘要:The present invention provides novel and more efficient synthesis's for obtaining an intermediate in the synthesis of obtaining a protecting group aminoxy PEG linker.

专利号:US-2009162290-A1
优先权日:2005-09-09
标 题 :Method for the synthesis of penta-pendant enantiomer-pure chelators and process for therapeutically active bioconjugates preparation by a covalent binding thereof
发明人：BENES IVAN; CIHELNIK SIMON; DROZ LADISLAV; SRAMEK MARTIN
权利人:THERAPHARM GMBH
摘要:The present invention provides a method for synthesis and binding methods of pentapendant enantiomer-pure chelators of formula (VII) wherein R 1 , R 2 , R 3 , R 4 are groups forming an adequate enantiomer of the chelator; and X 1 -X 5 , Y 1 -Y 5 , Z 1 -Z 5 each individually forming pendant chelating groups.

专利号:US-2009263858-A1
优先权日:2004-09-14
标 题 :Process for synthesis of mucin-type peptides and muc1-related glycopeptides
发明人：NISHIMURA SHINICHIRO; HINOU HIROSHI; FUMOTO MASATAKA
权利人:SHIONOGI & CO
摘要:The invention aims at providing novel compounds useful as primer in producing mucin-type glycopeptides which are useful in a wide field including materials for biochemical research, drugs, and food and the production of which was difficult in the prior art; and a process for the production of glycopeptides by using the primers. The aim is attained by providing novel glycopeptide derivatives (represented by the general formula (I)) which each bear an aldehyde or ketone group at the end and each contain an amino acid residue cleavable with a protease; and an easy and simple process for the production of glycopeptides by using the derivative as the primer.

专利号:US-8247534-B2
优先权日:2006-12-13
标题 :Synthesis of radiofluorinated peptide using microwave activation technology
发明人：WILLIAMS LORENZO
权利人:WILLIAMS LORENZO; GE HEALTHCARE AS
摘要:The present invention addresses a novel method of preparing radiofluorinated peptide-based compounds and introducing those compounds into an automated radiosynthesis apparatus with the aid of microwave activation. The present invention further relates to obtaining radiopharmaceutical kits utilizing microwave activation technology for the preparation of obtaining peptide based compounds as well as a method for the use of preparing a peptide based compound.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.