专利号:US-9440928-B2 优先权日:2011-07-20 标题 :Process for the synthesis of N-substituted cyclic alkylene ureas 发明人:GUPTA RAM; KOBYLANSKA IRINA; TREASURER URVEE; FLOOD LAWRENCE 权利人:GUPTA RAM; KOBYLANSKA IRINA; TREASURER URVEE; FLOOD LAWRENCE; ALLNEX IP S AR L 摘要:The invention relates to a process for the synthesis of N-substituted cyclic alkylene ureas by reacting a multifunctional aliphatic amine A having at least two amino groups which may be primary or secondary, at least one of which is a primary amino group, —NH 2 , and at least one of which is a secondary amino group, >NH, the other hydrogen group whereof having been substituted by a hydrocarbyl group which in turn may be substituted by a hydroxyl group, or an amino group, or a carboxyl group, or a ketone carbonyl group, or a hydrazide or hydrazone group, or a mercaptan group, and at least one further functional group selected from the group consisting of primary or secondary amino groups and hydroxyl groups, and an aliphatic organic carbonate component C selected from the group consisting of dialkyl carbonates CD and of alkylene carbonates CA.
专利号:US-4709034-A 优先权日:1986-02-14 标 题 :Process for the synthesis of hydroxyalkyl amines and hydroxyalkyl piperazines 发明人:MARSELLA JOHN A 权利人:AIR PROD & CHEM 摘要:The present invention comprises a process for the synthesis of hydroxyalkyl amines, hydroxyalkyl piperazines, or alkyl piperazines from alkylene glycols and ammonia or alkyl amines using a substantially soluble transition metal carbonyl complex catalyst precursor.
专利号:US-6110907-A 优先权日:1997-04-30 标题 :Synthesis of platinum complexes and uses thereof 发明人:AU-YEUNG STEVE C F; HO YEE PING; GE LIN; XIUWEN HAN; XINNING WANG; SHIWEI LU; TAO JIANG 权利人:DALIAN CHEMICAL PHYSICS INST; UNIV HONG KONG CHINESE 摘要:This invention provides novel antitumor demethylcantharidin platinum complexes. This invention also provides a composition comprising at least one of said demethylcantharidin platinum complexes and a suitable carrier. This invention provides a pharmaceutical composition comprising effective amount of at least one of the said demethylcantharidin platinum complexes and a pharmaceutically acceptable carrier. This invention provides a method of inhibiting the growth of tumorous cells comprising contacting the cells with an amount of said demethylcantharidin platinum complex effective to inhibit the growth of said tumorous cells. This invention provides a method of inhibiting the growth of tumorous cells in a subject comprising administering to the subject with an amount of the said demethylcantharidin platinum complexes effective to inhibit the growth of said tumorous cells in the subject. Finally, this invention provides methods for producing said demethylcantharidin platinum complexes.
专利号:US-10479768-B2 优先权日:2015-05-04 标 题 :Process for the preparation of amphiphilic imidazolinium compounds 发明人:BRÜNJES MARCO; FORD MARK JAMES 权利人:BAYER ANIMAL HEALTH GMBH 摘要:The present invention generally relates to improved processes for the preparation of amphiphilic imidazolinium compounds such as 1-[2-(9(Z)-octadecenoyloxy)ethyl]-2-(8(Z)-heptadecenyl)-3-(2-hydroxyethyl)imidazolinium chloride (DOTIM). In particular, the invention relates to processes for the synthesis of such compounds that avoid the need for toxic reagents, are more economical, and result in less waste than conventional methods. DOTIM and similar compounds can be formulated as cationic liposomes, which are useful as chemical vectors for nucleic acid delivery in gene therapy.
专利号:US-8828269-B1 优先权日:2009-11-16 标题:Method for increasing miscibility of natural oil polyol with petroleum-based polyol 发明人:GARRETT THOMAS M; DU XIAN XIAN 权利人:GARRETT THOMAS M; DU XIAN XIAN 摘要:A method of forming a stable mixture of a natural plant oil polyol and a petroleum-based polyol, including mixing a natural plant oil polyol with a monoglyceride, followed by adding a petroleum based polyol. Stabilized mixtures of plant oil and petroleum-based polyols can be used for synthesis of polyurethanes.
专利号:US-2009111737-A1 优先权日:1999-05-24 标题:Novel antibacterial agents 发明人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES 权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES 摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.
参考文献:10.1021/jp201922w 摘要:Varadwaj PR, Cukrowski I, Perry CB, Marques HM. A density functional theory and quantum theory of atoms-in-molecules analysis of the stability of Ni(II) complexes of some amino alcohol ligands. J Phys Chem A. 2011 Jun 23;115(24):6629–40. doi: 10.1021/jp201922w. 摘要:Kantlehner, W., Science of Synthesis, (2006) 24, 664.