CAS: 4439-20-7; N,N'-Bis(2-Hydroxyethyl)Ethylenediamine

该化合物是一种多用途有机化合物,其二乙醇基骨由乙烷-1,2-二基乙基航天仪连接,具有发泡特性,有助于化学和金属离子固存协调,其双功能性可应用于聚合合成,特别是作为交叉结合剂或单体改性剂.该化合物在极地溶解剂中的溶解性增强了其在水溶剂中的效用,而其矿泉水和氢氧基组则能够进一步发挥作用.该化合物还被用于表面活性系统,并因其与金属表面的相互作用能力而受腐蚀抑制.平衡的水文多益性和再活性使该化合物成为特殊化学合成中有价值的中间体.

结构式图片

相似化合物

5657-17-0 111-41-1 60487-26-5

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号50-00-0 甲醛 | CAS号107-15-3 乙二胺 | CAS号36697-72-0 2,2'-双(2-恶唑啉) | CAS号111-41-1 羟乙基乙二胺 | CAS号107-07-3 2-氯乙醇 | CAS号123-91-1 1,4-二氧六环 | CAS号112-67-4 棕榈酰氯 | CAS号141-43-5 2-氨基乙醇 | CAS号111-42-2 二乙醇胺 | CAS号107-06-2 1,2-二氯乙烷 | CAS号296-35-5 1,4,7,10,13,16-... | CAS号75173-44-3 1,4,7,10-tetrao... | CAS号88483-95-8 2-[2-(2-hydroxy... | CAS号63632-68-8 1,2-Ethanediami...

合成工艺路线路线简述

  • 合成目标产物 N,N'-Bis(2-Hydroxyethyl)Ethylenediamine 主要起始原料 2-(2-Aminoethylamino)Ethanol And 2-Chloroethanol
  • (文献来源)合成步骤主要原料 2-(2-Aminoethylamino)Ethanol 和 2-Chloroethanol
2,2-双(2-唑啉)置于rhodium(Iv) Oxide,铂 氢气体系中,用 乙醇 作为反应溶剂,化学反应生成 N,N'-双(2-羟乙基)乙二胺
参考文献:Butula,I.; Karlovic,G.,Justus Liebigs Annalen Der Chemie,1976,P. 1455-1464
标题:Butula,I.; Karlovic,G.,Justus Liebigs Annalen Der Chemie,1976,P. 1455-1464

海关参考信息

专利信息


专利号:US-9440928-B2
优先权日:2011-07-20
标题 :Process for the synthesis of N-substituted cyclic alkylene ureas
发明人:GUPTA RAM; KOBYLANSKA IRINA; TREASURER URVEE; FLOOD LAWRENCE
权利人:GUPTA RAM; KOBYLANSKA IRINA; TREASURER URVEE; FLOOD LAWRENCE; ALLNEX IP S AR L
摘要:The invention relates to a process for the synthesis of N-substituted cyclic alkylene ureas by reacting a multifunctional aliphatic amine A having at least two amino groups which may be primary or secondary, at least one of which is a primary amino group, —NH 2 , and at least one of which is a secondary amino group, >NH, the other hydrogen group whereof having been substituted by a hydrocarbyl group which in turn may be substituted by a hydroxyl group, or an amino group, or a carboxyl group, or a ketone carbonyl group, or a hydrazide or hydrazone group, or a mercaptan group, and at least one further functional group selected from the group consisting of primary or secondary amino groups and hydroxyl groups, and an aliphatic organic carbonate component C selected from the group consisting of dialkyl carbonates CD and of alkylene carbonates CA.

专利号:US-4709034-A
优先权日:1986-02-14
标 题 :Process for the synthesis of hydroxyalkyl amines and hydroxyalkyl piperazines
发明人:MARSELLA JOHN A
权利人:AIR PROD & CHEM
摘要:The present invention comprises a process for the synthesis of hydroxyalkyl amines, hydroxyalkyl piperazines, or alkyl piperazines from alkylene glycols and ammonia or alkyl amines using a substantially soluble transition metal carbonyl complex catalyst precursor.

专利号:US-6110907-A
优先权日:1997-04-30
标题 :Synthesis of platinum complexes and uses thereof
发明人:AU-YEUNG STEVE C F; HO YEE PING; GE LIN; XIUWEN HAN; XINNING WANG; SHIWEI LU; TAO JIANG
权利人:DALIAN CHEMICAL PHYSICS INST; UNIV HONG KONG CHINESE
摘要:This invention provides novel antitumor demethylcantharidin platinum complexes. This invention also provides a composition comprising at least one of said demethylcantharidin platinum complexes and a suitable carrier. This invention provides a pharmaceutical composition comprising effective amount of at least one of the said demethylcantharidin platinum complexes and a pharmaceutically acceptable carrier. This invention provides a method of inhibiting the growth of tumorous cells comprising contacting the cells with an amount of said demethylcantharidin platinum complex effective to inhibit the growth of said tumorous cells. This invention provides a method of inhibiting the growth of tumorous cells in a subject comprising administering to the subject with an amount of the said demethylcantharidin platinum complexes effective to inhibit the growth of said tumorous cells in the subject. Finally, this invention provides methods for producing said demethylcantharidin platinum complexes.

专利号:US-10479768-B2
优先权日:2015-05-04
标 题 :Process for the preparation of amphiphilic imidazolinium compounds
发明人:BRÜNJES MARCO; FORD MARK JAMES
权利人:BAYER ANIMAL HEALTH GMBH
摘要:The present invention generally relates to improved processes for the preparation of amphiphilic imidazolinium compounds such as 1-[2-(9(Z)-octadecenoyloxy)ethyl]-2-(8(Z)-heptadecenyl)-3-(2-hydroxyethyl)imidazolinium chloride (DOTIM). In particular, the invention relates to processes for the synthesis of such compounds that avoid the need for toxic reagents, are more economical, and result in less waste than conventional methods. DOTIM and similar compounds can be formulated as cationic liposomes, which are useful as chemical vectors for nucleic acid delivery in gene therapy.

专利号:US-8828269-B1
优先权日:2009-11-16
标题:Method for increasing miscibility of natural oil polyol with petroleum-based polyol
发明人:GARRETT THOMAS M; DU XIAN XIAN
权利人:GARRETT THOMAS M; DU XIAN XIAN
摘要:A method of forming a stable mixture of a natural plant oil polyol and a petroleum-based polyol, including mixing a natural plant oil polyol with a monoglyceride, followed by adding a petroleum based polyol. Stabilized mixtures of plant oil and petroleum-based polyols can be used for synthesis of polyurethanes.

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.
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合成参考文献


参考文献:10.1021/jp201922w
摘要:Varadwaj PR, Cukrowski I, Perry CB, Marques HM. A density functional theory and quantum theory of atoms-in-molecules analysis of the stability of Ni(II) complexes of some amino alcohol ligands. J Phys Chem A. 2011 Jun 23;115(24):6629–40. doi: 10.1021/jp201922w.
摘要:Kantlehner, W., Science of Synthesis, (2006) 24, 664.
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