CAS: 491833-29-5; N-((1R,2R)-1-(2,3-Dihydrobenzo[b][1,4]Dioxin-6-yl)-1-Hydroxy-3-(Pyrrolidin-1-yl)Propan-2-yl)Octanamide

上下游产品

1-(3',4'-Ethylenedioxy)Phenyl-2-Octanoylamino-3-Pyrrolidino-1-Propanol
依利格鲁司特中间体5 (1R,2R)-2-Amino-1-(2,3-Dihydrobenzo[b][1,4]Dioxin-6-yl)-3-(Pyrrolidin-1-yl)Propan-1-Ol 491833-28-4
2-Amino-1-(2,3-Dihydrobenzo[b][1,4]Dioxin-6-yl)-3-(Pyrrolidin-1-yl)Propan-1-Ol
(1R,2R,1"S)-1-(2',3'-Dihydro-Benzo[1,4]Dioxin-6'-yl)-2-(2"-Hydroxy-1"-Phenyl-Ethylamino)-3-Pyrrolidin-1-Yl-Propan-1-Ol
Tert-Butyl ((1R,2R)-1-(2,3-Dihydrobenzo[b][1,4]Dioxin-6-yl)-1,3-Dihydroxypropan-2-yl)Carbamate 502483-55-8
(2R,3R)-2-((Tert-Butoxycarbonyl)Amino)-3-(2,3-Dihydrobenzo[b][1,4]Dioxin-6-yl)-3-Hydroxypropyl Methanesulfonate 502483-56-9
(R)-Tert-Butyl 4-((R)-(2,3-Dihydrobenzo[b][1,4]Dioxin-6-yl)(Hydroxy)Methyl)-2,2-Dimethyloxazolidine-3-Carboxylate 502483-53-6

(1R,2R)-octanoic Acid[2-(2,3-Dihydrobenzo[1,4]Dioxin-6-yl)-2-Hydroxy-1-Pyrrolidin-1-Ylmethylethyl]Amide Tartrate置于碳酸氢钠体系中,化学反应 0.5H,以54%的收率获得产物依利格鲁司特
参考文献: Crystalline Eliglustat Hydrochloride[fr] Chlorhydrate D'éliglustat Cristallin
标题: Crystalline Eliglustat Hydrochloride[fr] Chlorhydrate D'éliglustat Cristallin
摘要:结晶态盐酸依格司他.本公开还一般涉及包括结晶态盐酸依格司他的药物组合物,以及使用结晶态盐酸依格司他治疗高雪氏病的方法,以及获取这些形式的方法.

专利信息

专利号:US-9988364-B1
优先权日:2017-03-21
标题 :Process for synthesis of Eliglustat and intermediate compounds thereof
发明人：LIU YU; YU GUANNENG; ZHENG ZHIGUO
权利人:ZHEJIANG AUSUN PHARMACEUTICAL CO LTD
摘要:The present invention relates to a process for synthesis of Eliglustat and intermediate compounds thereof. In particular, the present invention relates to a process for synthesis of Eliglustat and pharmaceutically acceptable salts thereof, and relates to the intermediate compounds in the process and a process for preparation of the intermediate compounds.

专利号:US-9546161-B2
优先权日:2001-07-16
标题:Synthesis of UDP-glucose: N-acylsphingosine glucosyl transferase inhibitors
发明人：HIRTH BRADFORD H; SIEGEL CRAIG
权利人:GENZYME CORP
摘要:Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.

专利号:US-9556155-B2
优先权日:2006-05-09
标题:Methods of treating fatty liver disease
发明人：ZHAO HONGMEI; YEW NELSON S; CHENG SENG H; JIANG CANWEN; ARBEENY CYNTHIA MARIE
权利人:GENZYME CORP
摘要:The disclosure provides methods for treating fatty liver disease and associated conditions by inhibiting the synthesis of glucosphingolipids, as exemplified by the use of glucosylceramide synthase substrate analogs.

专利号:US-2003050299-A1
优先权日:2001-07-16
标 题 :Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors

专利号:US-7196205-B2
优先权日:2001-07-16
标题:Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors

专利号:US-2008058514-A1
优先权日:2001-07-16
标 题:Synthesis of udp-glucose: n-acylsphingosine glucosyltransferase inhibitors