CAS: 60372-77-2; (S)-Ethyl 2-Dodecanamido-5-Guanidinopentanoate Hydrochloride

相似化合物

2645-08-1 125401-63-0 125401-64-1

Nα-Lauroyl-Arginine Ethyl Ester置于盐酸,Sodium Chloride体系中,用 水,乙酸乙酯 作为反应溶剂,以99%的收率获得产物n-月桂酰基-L-精氨酸乙酯盐酸盐
参考文献:염기성 아미노산 기반 양이온성 계면활성제의 탈염법 및 결정화 정제 방법
标题:염기성 아미노산 기반 양이온성 계면활성제의 탈염법 및 결정화 정제 방법
摘要:本发明涉及一种基于碱性氨基酸的阳离子界面活性剂去盐方法的单晶化精制方法和引入多种有机酸的盐置换方法,具体而言,涉及一种稳定且能有效去盐具有优异生物降解性的阳离子界面活性剂的方法,一种能够简单地将其精制为单晶形式的方法,以及通过盐置换添加多种功能从而制备新型阳离子界面活性剂的制备方法.具体而言,基于碱性氨基酸的阳离子界面活性剂及其衍生物可以在保持一定ph值的情况下稳定地去盐而不改变酯化合物的结构,然后通过处理有机酸或无机酸以进行单晶化精制或添加新功能的阳离子界面活性剂制备.特别是,基于碱性氨基酸的界面活性剂如乙基硫酰基琼醇酸盐酸盐和碳酸钠饱和溶液等具有高稳定性,可以在去盐后再次用盐酸处理,从而获得纯净的单晶乙基硫酰基琼醇酸盐酸盐.通过添加功能性有机酸,可以轻松制备具有新的高生物降解性的阳离子界面活性剂,同时通过使用不同的阳离子界面活性剂,可以为新的应用产品开发增加新的功能.此外,本发明中使用的所有方法均不产生废物,并且使用的物质是食品添加剂,因此不会对环境造成污染或危害.

专利信息

专利号:US-10287242-B2
优先权日:2011-12-28
标 题:Process for the synthesis of highly pure cationic surfactant products
发明人：MEHTA DILIP S; SHASTRI MAYANK
权利人:MEHTA DILIP S; SHASTRI MAYANK; ORGANISTRY LLC
摘要:The present invention is related to synthesis of highly pure cationic surfactant products by eliminating or reducing impurities generation that has beset prior art. This is achieved through the N-acylation of ester of amino acid and its inorganic salts or its organic salts (e.g. amino acid or hydrochloride of amino acid or sulfate of amino acid or acetate of amino acid etc.) in non-hydrolytic or nearly non-hydrolytic reaction conditions involving mono or biphasic reaction system with fatty acid halide (C 4 to C 20 ), under moderate uniform basic condition yielding high purity N-acyl substituted amino acid ester, particularly ethyl lauroyl arginate. The present process achieves pH control through process strategy rather than the measurement and control steps. This ambient temperature process is stable through a range of temperature variation eliminating rigid low temperature control.

专利号:US-8278478-B2
优先权日:2009-09-30
标题 :Process for the synthesis of hydrochloride salt of N-fatty acylsubstituted amino acid ethyl esters
发明人：GHARE VISHWAS SADHU
权利人:GHARE VISHWAS SADHU
摘要:The present invention relates to a process for preparing hydrochloride salt of N-fatty acyl substituted amino acid ethyl ester. Said process includes the steps of: dissolving L-arginine ethyl ester dihydrochloride in distilled water with continuous agitation for a period of about 10 to about 20 minutes to obtain a clear solution; lowering the temperature of the clear solution to about 5° C. to about 10° C. to obtain a cooled solution; adjusting the pH of the cooled solution in the range of about 7 to about 8 by adding sodium hydroxide solution; adding at least one organic solvent to the clear solution with continuous agitation to obtain an intermediate mixture; condensing the intermediate mixture by simultaneously adding an acid halide and 20% sodium hydroxide solution at a temperature of about 7° C. to about 9° C. and at a pH in the range of about 7.2 to about 7.5 for about 2 hours to obtain a mixture; raising the temperature of the mixture to about 18 to about 20° C. followed by addition of sodium hydroxide to adjust the pH of the mixture to about 7.3; warming the mixture at a temperature of about 25 to about 30° C. to obtain a resultant mixture containing organic phase and aqueous phase; separating the organic phase and aqueous phase of the resultant mixture by settling the mixture; and distilling the organic phase under vacuum at a temperature of about 70° C. to about 75° C. to obtain a hydrochloride salt of ethyl lauroyl arginate.

专利号:US-2010152480-A1
优先权日:2008-12-16
标题 :Process for synthesis of cationic surfactants
发明人：SADHU GHARE VISHWAS
权利人:SADHU GHARE VISHWAS
摘要:The present invention relates to the methods of synthesizing hydrochloride salt of N-fatty acyl substituted amino acid ethyl ester which comprises a) condensation of aqueous solution of esterified amino acid with an acid halide to obtain an intermediate suspension and b) isolating a hydrochloride salt of N-fatty acylsubstituted amino acid ethyl ester from the intermediate suspension.

专利号:EP-3604273-A2
优先权日:2011-12-28
标 题 :Process for the synthesis of highly pure cationic surfactant products

专利号:US-2014323756-A1
优先权日:2011-12-28
标题:Process for the synthesis of highly pure cationic surfactant products

专利号:EP-2797874-A1
优先权日:2011-12-28
标 题:Process for the synthesis of highly pure cationic surfactant products