N-(2-甲基-6-硝基苯基)-乙酰胺置于硫酸,Permanganate(Vii) Ion,Magnesium Sulfate体系中,化学反应生成 2-氨基-3-硝基苯甲酸 参考文献:James; Kenner; Stubbings,Journal Of The Chemical Society,1920,Vol. 117,P. 775 标题:James; Kenner; Stubbings,Journal Of The Chemical Society,1920,Vol. 117,P. 775
专利号:US-6608193-B2 优先权日:2001-12-21 标题 :Methods for synthesis of amino-tetrahydroisoquinoline ring compounds 发明人:LIU SONG; RENNELLS WILLIAM MARTIN 权利人:PROCTER & GAMBLE 摘要:Methods of preparing amino-substituted-tetrahydroisoquinoline ring compounds include the steps of providing a support-bound amino-substituted-tetrahydroisoquinoline compound; forming an intermediate by reacting the support-bound amino-substituted-tetrahydroisoquinoline compound with a reagent; and cyclizatively cleaving the support-bound amino-substituted-tetrahydroisoquinoline compound to form the amino-substituted-tetrahydroisoquinoline ring compound.
专利号:WO-2008012852-A1 优先权日:2006-07-27 标 题:Intermediate compounds for the preparation of angiotensin ii antagonists 发明人:GUANDALINI LUCA; MARTINI ELISABETTA; ROMANELLI MARIA NOVELLA; DALLATOMASINA FRANCO 权利人:S I M S S R L SOC IT MEDICINAL; GUANDALINI LUCA; MARTINI ELISABETTA; ROMANELLI MARIA NOVELLA; DALLATOMASINA FRANCO 摘要:The present invention relates to novel substituted biphenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists, to a process for the synthesis of them and to a process for the conversion thereof to said molecules.
专利号:US-2006122240-A1 优先权日:2002-11-05 标题 :Benzotriazoles and methods of prophylaxis or treatment of metabolic-related disorders thereof 发明人:SEMPLE GRAEME; SKINNER PHILIP J; CHERRIER MARTIN C; WEBB PETER; TAMURA SUSAN Y 权利人:ARENA PHARM INC 摘要:The present invention relates to certain benzotriazole carboxylic acid or ester derivatives of Formula (I), pharmaceutically acceptable salts and solvates thereof, which exhibit useful pharmaceutical properties, for example, as agonists for the GPCR referred to as hRUP38. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the prophylaxis or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of -glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.
专利号:RU-2024523-C1 优先权日:1989-09-08 标 题:Method of synthesis of tetrahydro-[1,4]-benzodiazepine-2-thiones or their pharmaceutically acceptable acid additive salts or stereochemical isomers
专利号:US-2002077480-A1 优先权日:2001-12-21 标 题:Methods for synthesis of amino-tetrahydroisoquinoline ring compounds
专利号:SU-1748647-A3 优先权日:1988-03-18 标 题 :Method for synthesis of tetrahydroimidazo-(1,4)- benzodiazepine-12-onÑŠs or theirs joining salts or pharmaceutically acceptable acids or theirs stereochemically isomeric forms