CAS: 78-95-5; Chloroacetone

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CAS号67-64-1 丙酮 | CAS号4749-28-4 2-硝基-1-丙烯 | CAS号127-00-4 1-氯-2-丙醇 | CAS号4755-81-1 2-氯乙酰乙酸甲酯 | CAS号115290-60-3 {Pd2(μ-H)(C°CH3... | CAS号590-21-6 1-氯-1-丙烯 | CAS号2684-62-0 DIAZOACETONE | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号201230-82-2 carbon monoxide | CAS号106-89-8 环氧氯丙烷 | CAS号110817-94-2 6-溴-3-(2-氧代丙基)-... | CAS号105492-42-0 4-(2-oxopropyl)... | CAS号112254-12-3 1-hexadecylsulf... | CAS号1111638-05-1 6-溴-2-甲基咪唑并[1,2-a]嘧啶 | CAS号430-51-3 氟代丙酮 | CAS号53012-41-2 1-(2`,6`-二甲氧基)-2-丙酮 | CAS号49615-96-5 1-(3-氨基-1-苯并呋喃-... | CAS号311-28-4 四丁基碘化铵 | CAS号90826-95-2 Phosphinecarbon... | CAS号37493-16-6 (S)-1-氯-2-丙醇

1-氯-2-丙醇置于ruthenium(Iv) Oxide,Sodium Chloride体系中,用 水,乙酸乙酯 作为反应溶剂,化学反应生成 一氯丙酮
参考文献:Indirect Electrooxidation Of Halohydrins By A Double Mediatory System Of Ru(Viii)/ru(Iv) And [cl+]/cl−. Optimization For The Oxidation Of 1,3-Dichloro-2-Propanol To 1,3-Dichloroacetone
标题:Indirect Electrooxidation Of Halohydrins By A Double Mediatory System Of Ru(Viii)/ru(Iv) And [cl+]/cl−. Optimization For The Oxidation Of 1,3-Dichloro-2-Propanol To 1,3-Dichloroacetone
摘要:使用ru(Viii)/ru(Iv)和[cl+]/cl−双氧化还原系统,对1,3-二氯-2-丙醇(1)进行电氧化反应生成1,3-二氯丙酮(2)的最佳条件已被阐明.在分隔电池中,将1在乙酸乙酯-水相nacl(2:3 V/v)体系中于0-5°C,Ph 2-4条件下进行电解,1以98%的选择性转化为1,1,3-三氯丙酮(3),电流效率为92%.
DOI:10.1246/bcsj.63.852

专利信息

专利号:US-8822702-B2
优先权日:2002-12-20
标 题 :Synthesis of amines and intermediates for the synthesis thereof
发明人：BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL
权利人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL; BASF SE
摘要:The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, n nor especially of amides of the formula II,n n nwherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.

专利号:US-11891375-B2
优先权日:2021-07-26
标 题 :Method for the synthesis of 2,4-dimethylpyrimidin-5-ol, intermediates, and method for the synthesis of Lemborexant using the intermediates
发明人：AKHATOU ABDESLAM; DOBARRO RODRÃ?GUEZ ALICIA
权利人:MOEHS IBERICA SL
摘要:A method is for the synthesis of 2,4-dimethylpyrimidin-5-ol, which can be used as an intermediate compound in the synthesis of Lemborexant. The method includes reacting a nitrophenyl compound with N,N-dimethylformamide diethyl acetal.

专利号:US-10392361-B2
优先权日:2016-01-21
标题:Process for the synthesis of intermediates of Nebivolol
发明人：BARTOLI SANDRA; MANNUCCI SERENA; GRISELLI ALESSIO; STEFANINI ALESSIO
权利人:MENARINI INT OPERATIONS LUXEMBOURG SA
摘要:The present invention relates to a novel process for the synthesis of the intermediate compounds constituted by chromanyl haloketones of formula III and 6-fluoro-2-(oxiran-2-yl)chromans of formula I. n The intermediates thus obtained can be used for the synthesis of Nebivolol.

专利号:EP-0454867-B1
优先权日:1989-11-17
标题:A METHOD FOR THE SYNTHESIS OF $g(a), $g(b)-UNSATURATED KETONES
发明人：TSUKASHIMA KEIICHI TAKAOKA PLA; NAKAJIMA MASASHI TAKAOKA PLANT; FUJIMARU MASAYOSHI TAKAOKA PLA; SUZUKI KENJI TAKAOKA PLANT
权利人:NIPPON SODA CO
摘要:The present invention relates to a method for the synthesis of alpha , beta -unsaturated ketones which comprises, in the method for the synthesis of alpha , beta -unsaturated ketones represented by general formula (I) (where R<1> is an aliphatic group with a side chain at the 1 position, an alicyclic group, a substituted alicyclic group, a heterocyclic group, a substituted heterocyclic group, a phenyl group or a substituted phenyl group), reacting aldehydes represented by general formula (II): R<1>CHO (where R<1> is as defined above) with alkali metal salt of acetoacetic acid represented by general formula (III) (where M<+> is an alkali metal ion), in the presence as a catalyst of 3-azabicyclo[3,2,2] nonane, a cyclic secondary amine represented by general formula (1) (where n is 3 or more and up to 5, m is 1 or more and up to 10, R<2> is an alkyl group having 1 to 10 carbon atoms and of straight chain or with side chains, an alkyl group substituted by alicyclic groups or phenyl groups, an alicyclic group which may be substituted by lower alkyl groups, or a phenyl group which may be substituted by lower alkyl groups, and an R<2> substitution position is at a carbon atom other than the two adjacent to N), a cyclic secondary amine represented by general formula (2) (where l is 1 or more and up to 6, a ring with N is a 6-membered, 7-membered or 8-membered ring, the two neighbors of N are methylene, R<3> is a lower alkyl group, its substitution position is at a carbon atom other than the two adjacent to N, and (a) is an alicyclic group or a phenyl group), or a secondary amine represented by general formula (3): CH3NHCH2R<4> (where R<4> is an aliphatic group having 5 to 17 carbon atoms and of straight chain or with side chains, an alicyclic group which may be substituted by lower alkyl groups, a phenyl group which may be substituted by lower alkyl groups, or an alkyl group substituted by phenyl groups), in a mixture solvent of water and water-insoluble organic solvent, while keeping the pH constant with mineral acid, and by adjusting the amount of water.

专利号:US-5484949-A
优先权日:1993-01-29
标题:Method for the synthesis of α β-unsaturated ketones
发明人：TSUKASHIMA KEIICHI; NAKAJIMA MASASHI; FUJIMARU MASAYOSHI; SUZUKI KENJI
权利人:NIPPON SODA CO
摘要:The present invention relates to a method for the synthesis of alpha , beta -unsaturated ketones which comprises, in the method for the synthesis of alpha , beta -unsaturated ketones represented by general formula reacting aldehydes represented by general formula R1CHO (where R1 is as defined above) with alkali metal salt of acetoacetic acid represented by general formula sence as a catalyst of 3-azabicyclo[3,2,2]nonane, a cyclic secondary amine represented by general formula (1) (1) a cyclic secondary amine represented by general formula (2) (2) (where, l is 1 or more and up to 6, a ring with N is a 6-membered, 7-membered or 8-membered ring, the two neighbors of N are methylene, R3 is a lower alkyl group, its substitution position is at a carbon atom other than two those adjacent to N, and is an alicyclic group or a phenol group), or a secondary amine represented by general formula (3) CH3NHCH2R4(3) in a mixuture solvent of water and water-insoluble organic solvent, while keeping the pH constant with mineral acid, and by adjusting an amount of water.

专利号:WO-2022127640-A1
优先权日:2020-12-16
标题:Process for synthesis of furan-based diamines
发明人：GUO RUIJING; PIRES RAUL; BEUCK SASKIA; LATORRE MARTINEZ IRENE CRISTINA; PAN XIANGCHENG; JIANG YUAN
权利人:COVESTRO DEUTSCHLAND AG; GUO RUIJING
摘要:The invention provides a process for the synthesis of furan-based diamines based on renewable resources.