CAS: 871-70-5; Octadecanedioic Acid

上下游产品

eicosa-1,19-diene 1,14-dibromotetradecane sodium diethylmalonate 18-hydroxystearic acidp-tolyl ester°Ctadecanedioic acid di-p-tolyl ester dimethyl 1,18-°Ctadecanedioate cycloheptadecanone 1,18-bis-(2,4-dihydroxy-phenyl)-°Ctadecane-1,18-dione

壬酸 反应生成 十八烷二酸
参考文献:Garg,S.P. Et Al.,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1979,Vol. 17B,P. 396
标题:Garg,S.P. Et Al.,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1979,Vol. 17B,P. 396

专利信息

专利号:WO-2023012709-A1
优先权日:2021-08-05
标 题 :An improved process for fmoc synthesis of semaglutide
发明人：LOBO LESTER JOHN; CHANDRAKESAN MURALIDHARAN; DOSHI CHETAN; CHANADAK SHAILESH LALCHAND; YADAV NANDLAL GOPAL; MOHE NIKHIL UMESH; VISHWANATHAN KODANDARAMAN
权利人:USV PRIVATE LTD
摘要:The present invention relates to an improved process for the synthesis of glucagon-like-peptide-1 (GLP-1) and its analogs by using combination of solid and solution phase synthesis of Fmoc protected amino acids in a sequential manner, optionally incorporating Boc protected dipeptide for unnatural amino acid in the Sequence of GLP-1, cleaving GLP-1 sequence from the resin followed by purification; attaching side-chain to the desired amino acid in the solution phase to synthesize desired GLP-1 analog, purifying it to Semaglutide. Temperature gradient is applied during initial coupling of amino acids to facilitate completion of difficult coupling reactions.

专利号:US-2024368099-A1
优先权日:2022-01-18
标 题:Methods for the synthesis of di(hydroxymethyl)tetrahydrofuran and its application in polyesters and polyurethanes
发明人：SPIEGELBERG BRIAN; BRANDT ADRIAN; BECK HORST; KUX ALEXANDER; TIN SERGEY; DE VRIES JOHANNES GERARDUS
权利人:HENKEL AG & CO KGAA
摘要:The present invention relates to the synthesis of di(hydroxymethyl)tetrahydrofuran (DHMTHF) and the preparation of trans-enriched mixtures of DHMTHF. The invention further refers to polyester polyols which are obtained by reaction of cis/trans DHMTHF mixtures with a dicarboxylic acid. The invention further relates to polyurethanes and compositions containing a polyester polyol comprising DHMTHF, in particular to such polyurethane-containing (adhesive) compositions.

专利号:US-2019177392-A1
优先权日:2014-09-23
标 题 :Synthesis of glp-1 peptides
发明人：PENIAS NAVON SHARON; NAVEH SHIRLY; VASILEIOU ZOI; BARLOS KONSTANTINOS
权利人:NOVETIDE LTD
摘要:Disclosed are processes for the synthesis of GLP-1 peptides, such as liraglutide and semaglutide, and a process for purifying liraglutide.

专利号:US-8053522-B2
优先权日:2006-02-28
标题 :Synthesis of polyester-graft-poly(meth)acrylate copolymers
发明人：LOEHDEN GERD; BALK SVEN; BRAND THORSTEN; BRENNER GABRIELE; ARNOLD THOMAS; BAUMANN CORNELIA
权利人:EVONIK ROEHM GMBH
摘要:The present invention relates to a novel synthesis of (meth)acrylate-grafted polyesters and their action as compatibilizers.

专利号:US-11186608-B2
优先权日:2017-12-21
标 题 :Solid phase synthesis of acylated peptides
发明人：SCHOENLEBER RALPH O; LOIDL GUENTHER
权利人:BACHEM HOLDING AG
摘要:The present invention relates to methods and compounds for the solid phase synthesis of peptides carrying a substituent at an amino group of an amino acid side chain.

专利号:US-10858414-B2
优先权日:2018-03-09
标 题:Chemo-enzymatic synthesis of semaglutide, liraglutide and GLP-1
发明人：NUIJENS TIMO; TOPLAK ANA; QUAEDFLIEG PETER JAN LEONARD MARIO
权利人:ENZYPEP B V
摘要:The invention relates to a method for preparing a coupling product having the sequence P q -W v -His-X-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Y-Glu-Phe-Ile-Ala-Trp-Leu-Val-Z-Gly-Arg-Gly. The method includes enzymatically couplingn (a) a peptide C-terminal ester or thioester having a first peptide fragment represented by the formula P q -W v -His-X-Glu-(thio)ester; and (b) a peptide nucleophile having an N-terminally unprotected amine having a second peptide fragment with the sequence H-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Y-Glu-Phe-Ile-Ala-Trp-Leu-Val-Z-Gly-Arg-Glyn whereinn P represents a protective group at the N-terminal α-amino function of the peptide C-terminal ester or thioester and q is an integer having a value of 1 or 0; W represents one or more amino acid residues, which may be the same or different and v is an integer having a value of 1 or more representing the number of amino acid residues W; X is Ala or an α-amino-isobutyric acid unit (Aib); Y is Lys, which Lys has a free side-chain ε-amino group or a side-chain ε-amino group that is protected with a protective group or a side-chain ε-amino group that is functionalized with an amino acid or another functional group; and n Z is Arg or Lys.