CAS: 99-73-0; 2,4'-Dibromoacetophenone

上下游产品

CAS号99-90-1 4-溴苯乙酮 | CAS号159755-11-0 1-bromo-4-(1-br... | CAS号57342-22-0 2-bromo-1-(4-br... | CAS号1585-07-5 1-溴-4-乙基苯 | CAS号2039-82-9 对溴苯乙烯 | CAS号13195-79-4 2,2,4'-三溴苯乙酮 | CAS号108-86-1 溴苯 | CAS号1007882-39-4 (2s)-2-[5-(4-溴苯... | CAS号111946-84-0 1-(4-bromopheny... | CAS号10536-76-2 [2-(4-bromophen... | CAS号1057142-91-2 ethyl 2-amino-5... | CAS号7500-37-0 4'-溴-2-羟基苯乙酮乙酸酯 | CAS号3343-45-1 1-(4-溴苯基)-2-羟基乙基-1-酮 | CAS号104819-39-8 3-[6-(4-bromoph... | CAS号105996-44-9 [2-(4-bromophen... | CAS号336182-29-7 4-溴-N-异丙基苯甲酰胺 | CAS号32017-76-8 2-(4-溴苯基)环氧乙烷

乙基苯置于oxone,Sodium Bromide体系中,用 水,乙腈 作为反应溶剂,以65%的收率获得产物2,4'-二溴苯乙酮
参考文献:烷基苯的双氧化/溴化
标题:烷基苯的双氧化/溴化
摘要:在溴化钠和oxone的存在下,一系列烷基苯衍生物被溴化和/或氧化,最多可官能化四个ch键.
DOI:10.1016/j.Tetlet.2016.01.062

专利信息

专利号:EP-4092127-A1
优先权日:2021-05-18
标题:Enzyme-catalytic method for the direct stereoselective synthesis of gamma-(acyloxy) carboxylic acids
发明人：PARVE JAAN; KUDRJASHOVA MARINA; GATHERGOOD NICHOLAS; PARVE OMAR
权利人:TALLINN UNIV OF TECHNOLOGY
摘要:The present invention is a method for the stereoselective straightforward synthesis of gamma-acyloxy carboxylic acids of novel structure starting from racemic gamma-hydroxy carboxylic acid salts that are obtained by alkaline hydrolysis of the racemic gamma-lactones. The salt is acylated by enzyme catalysis in an organic solvent containing an acyl donor and an immobilised lipase, on stirring at room temperature (ca 20 °C) until reaching the conversion rate required. After that, the reaction mixture is acidified and extracted and the product treated with catalytic amount of para-toluenesulfonic acid in toluene during the time required for the relactonisation of the unreacted salt enantiomer. Thereafter, the target gamma-acyloxy carboxylic acid formed from one enantiomer of the starting compound and relactonised gamma-lactone formed from the other, unreacted enantiomer of the starting compound are isolated using a routine separation method, such as distillation, extraction with NaHCO3 water solution followed by acidification or column chromatography.

专利号:WO-2021038581-A1
优先权日:2019-08-30
标题 :A one step synthesis of 2-substituted benzo[b]thiophenes
发明人：SEKAR GOVINDASAMY; POONGUZHALI ELAMVAZHUTHI
权利人:INDIAN INST TECH MADRAS
摘要:The invention pertains to a one step synthesis of 2-substituted benzo[ b ]thiophene of general formula wherein the synthesis of 2-substituted benzo[ b ]thiophenes is by reacting the starting materials substituted or unsubstituted 2-halogenobenzaldehyde and substituted or unsubstituted acetyl/phenacyl bromide with a catalyst, a sulphur source and phase transfer catalyst in an aqueous medium with atmospheric air and at temperature in the range of 25°C-30°C.

专利号:WO-0132645-A1
优先权日:1999-11-04
标题:The synthesis of extended bis(ethylenedithio)tetrathiafulvalene derivatives and their dihydroxyl analogues
发明人：OZTURK TURAN; TURKSOY FIGEN; WALLIS JOHN D; UMIT TUNCA
权利人:TUBITAK MARMARA RES CT; OZTURK TURAN; TURKSOY FIGEN; WALLIS JOHN D; UMIT TUNCA
摘要:The present invention describes the synthesis of six novel derivatives of bis(ethylenedithio)tetrathiafulvalene (BEDT-TTF), utilising the recently developed reaction of 1,8-diketones with Lawesson's reagent. These new BEDT-TTF derivatives (1)-(6) have potential to delocalise the positive charges formed during change-transfer salts to the peripheral. In addition to their positive charge delocalisation feature, the compounds (1)-(3) have the potential of being introduced hydrogen bonding groups and the compound (4)-(6) already have hydrogen bonding hydroxyl groups. All the new BEDT-TTF (7) derivatives described in this invention have shown comparative CV measurements with the BEDT-TTF. Each of these bis(ethylenedithio)tetrathiafulvalene derivatives of the present invention has a unique and novel structure which can not be found in the prior art and is useful for the development of new organic charge-transfer complexes.

专利号:US-5352587-A
优先权日:1989-06-23
标 题:Compositions and methods for the synthesis of natriuretic protein receptor B and methods of use
发明人：CHANG MING-SHI; GOEDDEL DAVID V; LOWE DAVID G
权利人:GENENTECH INC
摘要:PCT No. PCT/US90/03586 Sec. 371 Date Dec. 19, 1991 Sec. 102(e) Date Dec. 19, 1991 PCT Filed Jun. 22, 1990 PCT Pub. No. WO91/00292 PCT Pub. Date Jan. 10, 1991.Described are the amino acid sequence of natriuretic peptide receptor B (NPRB) and DNA encoding NPRB. Also disclosed are expression vectors and cells transformed to express the NPRB, DNA encoding NPRB and diagnostic and therapeutic uses for the NPRB and the DNA encoding NPRB.

专利号:US-8541191-B2
优先权日:2008-08-29
标 题 :Hydrolases, nucleic acids encoding them and methods for biocatalytic synthesis of structured lipids
发明人：DAYTON CHRISTOPHER L G; HITCHMAN TIM; KLINE KATIE; LYON JONATHAN; WALL MARK A; BARTON NELSON R
权利人:DAYTON CHRISTOPHER L G; HITCHMAN TIM; KLINE KATIE; LYON JONATHAN; WALL MARK A; BARTON NELSON R; BUNGE OILS INC
摘要:Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils, such as low saturate or low trans fat animal or vegetable oils, e.g., soy or canola oils.

专利号:US-9090661-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.