专利号:US-5663480-A 优先权日:1993-12-20 标题:Synthesis of aromatic carbonates by transesterification using a catalyst comprising a microporous material and a group IV metal 发明人:TSUNEKI HIDEAKI; KIRISHIKI MASARU; WATANABE KENICHI; ONDA YOSHIYUKI 权利人:NIPPON CATALYTIC CHEM IND 摘要:A catalyst for producing an aryl ester of a carbonic or carboxylic acid is disclosed, which includes a microporous material containing a metal element belonging to group IV. This catalyst can be used as a heterogeneous catalyst to produce the aryl ester in high yield with industrial advantages. In order to produce the aryl ester using the catalyst, a carbonate or an aliphatic carboxylate is transesterified with an aromatic hydroxy compound, or an aryl carboxylate is transesterified with a carbonate, or an alkyl aryl carbonate is disproportionated by transesterification.
专利号:US-7919630-B2 优先权日:2005-09-30 标题 :Synthesis of imidazole 2-thiones via thiohydantoins 发明人:GARST MICHAEL E; DOLBY LLOYD J; ESFANDIARI SHERVIN; AVEY JR ALFRED A; MACKENZIE VIVIAN ROSE; MUCHMORE CHARLES DAVID 权利人:ALLERGAN INC 摘要:The present invention provides a method of making an imidazole 2-thione which comprises the step(s) of reducing a thiohydantoin to said imidazole-2-thione.
专利号:US-5780588-A 优先权日:1993-01-26 标题:Elucidation and synthesis of selected pentapeptides 发明人:PETTIT GEORGE R; SRIRANGAM JAYARAM K 权利人:UNIV ARIZONA 摘要:The sea hare Dolabella auricularia has yielded many structurally distinct peptides which possess antineoplastic activity. Presently the compound denominated 'dolastatin 10' represents the most important of such peptides because of its demonstrated potential as an anticancer drug. n The present invention relates to the systematic creation of five unique pentapeptides by selectively coupling a tripeptide-trifluoroacetate salt with a preselected dipeptide-trifluoroacetate salt which provide active molecules capable of emulating the measured therapeutic effect of dolastatin 10. The pentapeptides hereof have the structure shown below: ##STR1## wherein R is selected from the following group of substituents: ##STR2##
专利号:US-7579294-B2 优先权日:2004-12-29 标题:Synthesis of supported transition metal catalysts 发明人:PARK JAIWOOK; KIM NAMDU; KWON MIN SERK; PARK CHEON MIN 权利人:POSTECH FOUNDATION 摘要:A highly active and recyclable supported transition metal catalyst can be prepared by a simple process comprising mixing with heating a transition metal complex, a metal-chelating agent and an alkoxide of Ti, Al or Si, followed by treatment with water to induce a sol-gel reaction among the reactants.
专利号:US-6262302-B1 优先权日:1996-11-22 标题:N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds 发明人:WU JING; TUNG JAY S; NISSEN JEFFREY S; MABRY THOMAS E; LATIMER LEE H; EID CLARK N; AUDIA JAMES E 权利人:ELAN PHARM INC; LILLY CO ELI 摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-2009137385-A1 优先权日:2004-12-29 标 题 :Synthesis of supported transition metal catalysts