CAS: 120-66-1; N-(O-Tolyl)Acetamide

相似化合物

2198-53-0 2727-68-6 2198-53-0

上下游产品

CAS号75-36-5 乙酰氯 | CAS号95-53-4 邻甲苯胺 | CAS号60-35-5 乙酰胺 | CAS号615-37-2 2-碘甲苯 | CAS号108-24-7 乙酸酐 | CAS号95-49-8 邻氯甲苯 | CAS号64-19-7 冰醋酸 | CAS号64-17-5 乙醇 | CAS号75-05-8 乙腈 | CAS号68253-33-8 E-ortho-methyla... | CAS号3970-40-9 2-氯-3-硝基甲苯 | CAS号5428-54-6 5-硝基-2-甲基苯酚 | CAS号41085-43-2 2-溴-3-硝基甲苯 | CAS号53857-57-1 5-溴吲唑 | CAS号50712-68-0 2-甲基-4-氯苯腈 | CAS号59907-22-1 2’-甲基-6’-硝基乙酰苯胺 | CAS号2719-15-5 2-甲基-4-硝基乙酰苯胺 | CAS号2879-79-0 N-(2-甲基-5-硝基苯基)乙酰胺 | CAS号606-46-2 N,N-二乙基邻甲苯胺 | CAS号94-68-8 N-乙基邻甲苯胺

3-乙基甲苯置于n-羟基邻苯二甲酰亚胺,氧气,Cobalt(II) Diacetate Tetrahydrate,甲酸,硝基甲烷,三氟甲磺酸酐体系中,用 溶剂黄146 用作溶剂,80.0~100.0 °C,101.33 Kpa 条件下,反应 24.0H,以65%的收率获得2-甲基乙酰苯胺
参考文献:硝基甲烷作为施密特型酰胺和腈形成中的氮供体
标题:硝基甲烷作为施密特型酰胺和腈形成中的氮供体
摘要:从硝基甲烷中获取氮气 硝基甲烷大量生产用作溶剂.它作为试剂的应用主要集中在甲基质子在改变碳中心的过程中的酸度.刘等人.现在报告一种替代方案,该方案激活氮中心以产生胺化剂.与三氟甲磺酸酐,甲酸和乙酸的原位还原反应产生乙酰化羟胺,通过质谱法表征.这种氮供体可以方便地将各种酮和醛转化为酰胺.科学,这个问题 P.281 方便地从硝基甲烷原位衍生的乙酰化羟胺可以将酮和醛转化为酰胺.自 1923 年发现以来,施密特反应一直是酰胺和腈的有效且广泛使用的合成方法.然而,其应用通常需要使用挥发性,潜在爆炸性和剧毒的叠氮试剂.在这里,我们报告了一个序列,其中三氟甲磺酸酐和甲酸和乙酸激活大量化学硝基甲烷,作为氮供体代替类施密特反应中的叠氮化物.该协议进一步将底物范围扩展到炔烃和简单的烷基苯,用于制备酰胺和腈.我们报告了一个序列,其中三氟甲磺酸酐和甲酸和乙酸激活大量化学硝基甲烷,作为氮供体代替类施密特反应中的叠氮
Doi:10.1126/science.Aay9501

专利信息

专利号:US-4766242-A
优先权日:1982-02-01
标 题:Synthesis of substituted aryl sulfides
发明人：HANSON HARRY T; SAPP JR JOHN B
权利人:HOECHST CELANESE CORP
摘要:Provided is a novel and effective process for the synthesis of aryl sulfides substituted with an alkanoylamino or (N-alkyl)alkanoylamino substituent. The process comprises reacting an appropriately substituted aromatic compound with a sulfur dihalide, preferably sulfur dichloride, in the presence of an alkali metal tetrafluoroborate catalyst and an ether comprising solvent.

专利号:US-9475770-B2
优先权日:2010-12-17
标 题 :Low-temperature synthesis of methylphenidate hydrochloride
发明人：HUNTLEY C FREDERICK M; KATAISTO ERIK WAYNE; LA LUMIERE KNICHOLAUS DUDLEY; REISCH HELGE ALFRED
权利人:HUNTLEY C FREDERICK M; KATAISTO ERIK WAYNE; LA LUMIERE KNICHOLAUS DUDLEY; REISCH HELGE ALFRED; RHODES TECH
摘要:The present invention describes a process for the preparation of methylphenidate hydrochloride. The process involves the esterification of ritalinic acid and methanol in the presence of an acid catalyst at a low temperature. The process may optionally involve the addition of an orthoester.

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:WO-9710221-A1
优先权日:1995-09-15
标 题:Synthesis of quinazolinone libraries
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TORREY PINES INST
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:US-6140505-A
优先权日:1995-03-10
标 题:Synthesis of benzo fused heterocyclic sulfonyl chlorides

专利号:WO-2010149359-A1
优先权日:2009-06-26
标 题 :Process and intermediates for the preparation of benzimidazolecarboxylic acids
发明人：HANSELMANN PAUL; WONG HEILAM; KLEGRAF ELLEN; ZARAGOZA DOERWALD FLORENCIO; DING ZUNLIANG; HE WEI RYAN
权利人:LONZA AG; HANSELMANN PAUL; WONG HEILAM; KLEGRAF ELLEN; ZARAGOZA DOERWALD FLORENCIO; DING ZUNLIANG; HE WEI RYAN
摘要:Substituted benzimidazolecarboxylic acids of formula (I), wherein R 1 and R 2 independently are hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl, are prepared in a four-step synthesis starting from N -acyl-4-haloanilines of formula (II), wherein R 1 is as defined above, R 3 is C 1-4 alkyl and X is chlorine or bromine.