CAS: 2368-80-1; (2-Fluorophenyl)Hydrazine

上下游产品

2-Fluoroaniline 2-fluorobenzenediazonium tetrafluoroborate butan-1-ol 1-chloro-2-fluorobenzene arabino-[2]hexosulose-bis-(2-fluoro-phenylhydrazone)D-arabino-[2]hexosulose-bis-(2-fluoro-phenylhydrazone) 5-amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile 1-(2-fluorophenyl)hydrazine-1-carbonitrile 1-(2-Fluor-phenyl)-semicarbazid

2-氟苯胺置于盐酸,Sodium Nitrite,Tin(Ll) Chloride体系中,用 水 用作溶剂,化学反应生成2-氟苯肼
参考文献:3D-Qsar 定向发现新型卤代苯基 3-三氟乙氧基吡唑含超高活性杀虫邻氨基苯甲酸二胺
标题:3D-Qsar 定向发现新型卤代苯基 3-三氟乙氧基吡唑含超高活性杀虫邻氨基苯甲酸二胺
摘要:害虫是造成全球作物损害和粮食安全问题的主要因素之一.基于我们之前发现的针对兰尼碱受体 (Ryrs) 的杀虫先导化合物的研究,建立了三维定量构效关系 (3D-Qsar) 模型,设计并合成了一系列含有卤代苯基 3 的邻氨基苯甲酸二酰胺-三氟乙氧基吡唑部分.初步生物测定表明,Iib,Iiib和iiif针对分离丝虫的活性与氯蒽甲酰胺相当(lc 50:分别为 0.16,0.16,0.14 和 0.13 Mg.l-1).超过一半的目标化合物显示出非常好的活性plutella Xylostella,其中iiif是最活跃的化合物,其活性是氯蒽甲酰胺的 25 倍(lc 50:6.0 x 10-6对 1.5 x 10-4 Mg.l-1).对于草地贪夜蛾,Iiif的效力略低于氯虫苯甲酰胺(lc 50:0.47 与 0.31 Mg.l-1).对于s. Frugiperda (G4891E,I4734M)
Doi:10.1021/acs.Jafc.2C05738

专利信息

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:US-8283476-B2
优先权日:2007-06-26
标 题:Transition metal catalyzed synthesis of 2H-indazoles
发明人：HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; RKYEK OMAR; URMANN MATTHIAS
权利人:HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; RKYEK OMAR; URMANN MATTHIAS; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional 2H-indazoles or 2H-azaindazoles of the formula (I) from 2-halo-phenylacetylenes or (2-sulfonato)phenylacetylenes and monosubstituted hydrazines.

专利号:US-6087534-A
优先权日:1995-12-29
标 题:Method for synthesizing aryl hydrazine through reduction of a diazo compound derivative
发明人：MAS JEAN-MANUEL; ROCHIN CHRISTOPHE
权利人:RHODIA CHIMIE SA
摘要:The invention involves a procedure for synthesizing aryl hydrazine through reduction of a diazo derivative. The distinguishing feature of the method is that it involves at least the following step: c) bringing a diazo derivative into contact with a sulphite solution in which the pH level is at least 7. Applications: organic synthesis.

专利号:US-2010234601-A1
优先权日:2007-06-26
标 题 :Transition metal catalyzed synthesis of 2H-indazoles

专利号:WO-2009000411-A1
优先权日:2007-06-26
标 题 :A transition metal catalyzed synthesis of 2h-indazoles

专利号:US-11027027-B2
优先权日:2015-01-30
标 题:Pyridazinoindole compounds and methods for PET imaging
发明人：MANNING H CHARLES; CHEUNG YIU-YIN; BUCK JASON R; LI JUN
权利人:UNIV VANDERBILT
摘要:Embodiments of the invention include a novel synthesis of the translocator protein (TSPO) ligands, and methods of imaging a molecular events. Also disclosed are compounds for treatment of diseases, including cancer.