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Tert-Butyl ((3-Chloro-5,6-Dicyanopyrazin-2-yl)Oxy)Carbamate置于乙酸-D3,锌体系中,用 二氧六环-D8 用作溶剂,化学反应 6.0H,反应生成2-(Boc-氨基)吡啶
参考文献:A Multifunctional Reagent Designed For The Site-Selective Amination Of Pyridines
标题:A Multifunctional Reagent Designed For The Site-Selective Amination Of Pyridines
摘要:We Report The Development Of A Multifunctional Reagent For The Direct Conversion Of Pyridines To Boc-Protected 2-Aminopyridines With Exquisite Site Selectivity And Chemoselectivity. The Novel Reagent Was Prepared On 200-G Scale In A Single Step,Reacts In The Title Reaction Under Mild Conditions Without Precautions Toward Air Or Moisture,And Is Tolerant Of Nearly All Common Functionality. Experimental And In Situ Spectroscopic Monitoring Techniques Provide Detailed Insights And Unexpected Findings For The Unique Reaction Mechanism.
Doi:10.1021/jacs.0C03537

专利信息

专利号:US-9758507-B2
优先权日:2010-07-01
标 题:Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors
发明人：SILVERMAN RICHARD B; XUE FENGTIAN
权利人:UNIV NORTHWESTERN
摘要:A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.

专利号:US-2021069337-A1
优先权日:2018-04-27
标题 :Integrin targeting ligands and uses thereof
发明人：LI ZHEN; CARLSON JEFFREY; NICHOLAS ANTHONY; LI XIAOKAI; SHU DONGXU; FOWLER-WATTERS MATTHEW
权利人:ARROWHEAD PHARMACEUTICALS INC
摘要:Compounds having affinity for integrins, the synthesis of these compounds, and the use of these compounds as ligands to facilitate the delivery of cargo molecules to cells expressing integrins are described. The described integrin targeting ligands have serum stability and affinity for αvβ3 integrin and/or αvβ5 integrin, and are suitable for conjugation to cargo molecules, such as such as oligonucleotide-based therapeutic agents (e.g., RNAi agents), to facilitate delivery of the cargo molecules to cells and tissues, such as tumor cells, that express integrin αvβ3, integrin αvβ5, or both integrin αvβ3 and integrin αvβ5. Compositions that include integrin targeting ligands and methods of use are also described.

专利号:US-8697879-B2
优先权日:2010-07-01
标 题:Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors

专利号:US-2012004415-A1
优先权日:2010-07-01
标 题 :Chiral Synthesis of Pyrrolidine Core Compounds en route to Neuronal Nitric Oxide Synthase Inhibitors

专利号:US-2016096821-A1
优先权日:2010-07-01
标 题:Chiral Synthesis of Pyrrolidine Core Compounds en route to Neuronal Nitric Oxide Synthase Inhibitors

专利号:CN-112574194-A
优先权日:2019-09-29
标 题:Synthesis and Application of Pyrimidine Salts