CAS: 55873-09-1; 2-Chloropyrimidin-4-Ol

该化合物是一种环环环化合物,其特点是氯化的火水晶芯,在4级具有氢氧基替代成分,这种结构赋予了适合核生殖器替代的再活性,使其成为制药和农用化学合成中有价值的中间体.2级氯原子可增强电益性,促进交叉反应,而氢氧基组则具有额外的功能化潜力.在标准条件下和与不同反应条件相容的情况下,这种结构使该物质成为制造复杂分子的多功能建筑块.应用包括开发活性药物成分和特殊化学品,而精确的功能性团体操纵至关重要.

结构式图片

相似化合物

22536-63-6 844843-37-4 13223-25-1

合成工艺路线路线简述

    2-氯-4-乙氧基嘧啶 反应生成 2-氯-4-羟基嘧啶
    参考文献:The Mechanism Of Thermal Eliminations. Part 18. Relative Rates Of Pyrolysis Of 2-Ethoxypyrazine,3-Ethoxypyridazine,2-And 4-Ethoxypyrimidine,3-Chloro-6-Ethoxypyridazine,And 2-Chloro-4-Ethoxypyrimidine: The Effect Of The Aza 'substituent' And π-Bond Order On The Elimination Rate
    标题:The Mechanism Of Thermal Eliminations. Part 18. Relative Rates Of Pyrolysis Of 2-Ethoxypyrazine,3-Ethoxypyridazine,2-And 4-Ethoxypyrimidine,3-Chloro-6-Ethoxypyridazine,And 2-Chloro-4-Ethoxypyrimidine: The Effect Of The Aza 'substituent' And π-Bond Order On The Elimination Rate
    摘要:
    DOI:10.1039/p29860001255

    海关参考信息

    专利信息


    专利号:US-9533959-B2
    优先权日:2013-10-07
    标 题:Methods of regioselective synthesis of 2,4-disubstituted pyrimidines
    发明人:CHARRIER JEAN-DAMIEN; O'DONNELL MICHAEL EDWARD
    权利人:VERTEX PHARMA
    摘要:The present invention relates to the novel regioselective syntheses of 2,4-disubstituted pyrimidines through sequential nucleophilic aromatic substitutions.

    专利号:US-6608199-B2
    优先权日:2000-07-07
    标题 :Synthesis of chlorinated pyrimidines
    发明人:DOYLE TIMOTHY JOHN; BENKE ALAN HENRY; WEHRENBERG PETER KARL; NADY LOUIE AKOS
    权利人:SYNGENTA LTD
    摘要:The invention provides a process for synthesizing chlorinated pyrimidines. The process includes reacting imidoyl chloride compounds with phosgene (COCl2). The imidoyl chloride compounds can be supplied as starting materials or can be produced by reacting organic amides with phosgene or reacting organic nitrites with hydrogen chloride. The chlorinated pyrimidines, such as 4,6-dichloropyrimidine, can be used to synthesize other compounds useful in a variety of compositions, such as fungicides, pesticides, and pharmaceuticals.

    专利号:US-6982331-B2
    优先权日:2001-06-08
    标 题 :Synthesis of chlorinated pyrimidines
    发明人:DOYLE TIMOTHY J; BENKE ALAN H; WEHRENBERG PETER K; NADY LOUIE A; RODRIGUEZ GILBERT
    权利人:SYNGENTA CROP PROT INC
    摘要:The invention provides a process for synthesizing chlorinated pyrimidines. The process includes reacting imidoyl chloride compounds with phosgene (COCl 2 ). The imidoyl chloride compounds can be supplied as starting materials or can be produced by reacting organic amides with phosgene or reacting organic nitrites with hydrogen chloride. Phosgene may be replaced by equivalent reagents. The chlorinated pyrimidines, such as 4,6-dichloropyrimidine, can be used to synthesize other compounds useful in a variety of compositions, such as fungicides, pesticides, and pharmaceuticals.

    专利号:US-2004054181-A1
    优先权日:2001-06-08
    标 题:Synthesis of chlorinated pyrimidines

    专利号:US-10005737-B2
    优先权日:2013-10-07
    标题:Methods of regioselective synthesis of 2,4-disubstituted pyrimidines

    专利号:US-2015099875-A1
    优先权日:2013-10-07
    标题:Methods of regioselective synthesis of 2,4-disubstituted pyrimidines
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    合成参考文献


    参考文献:10.1055/s-0037-1609906
    摘要:Goi T, Fukase K. Highly Efficient Coupling of Unstable Bicyclic Pyrimidines and Pyrazoles under Basic Conditions, and its Application to the Synthesis of Pharmaceutical Compounds. Synlett. 2018 Jul 31;29(14):1867–70. doi: 10.1055/s-0037-1609906.
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