2-氯-4-乙氧基嘧啶 反应生成 2-氯-4-羟基嘧啶 参考文献:The Mechanism Of Thermal Eliminations. Part 18. Relative Rates Of Pyrolysis Of 2-Ethoxypyrazine,3-Ethoxypyridazine,2-And 4-Ethoxypyrimidine,3-Chloro-6-Ethoxypyridazine,And 2-Chloro-4-Ethoxypyrimidine: The Effect Of The Aza 'substituent' And π-Bond Order On The Elimination Rate 标题:The Mechanism Of Thermal Eliminations. Part 18. Relative Rates Of Pyrolysis Of 2-Ethoxypyrazine,3-Ethoxypyridazine,2-And 4-Ethoxypyrimidine,3-Chloro-6-Ethoxypyridazine,And 2-Chloro-4-Ethoxypyrimidine: The Effect Of The Aza 'substituent' And π-Bond Order On The Elimination Rate 摘要: DOI:10.1039/p29860001255
专利号:US-9533959-B2 优先权日:2013-10-07 标 题:Methods of regioselective synthesis of 2,4-disubstituted pyrimidines 发明人:CHARRIER JEAN-DAMIEN; O'DONNELL MICHAEL EDWARD 权利人:VERTEX PHARMA 摘要:The present invention relates to the novel regioselective syntheses of 2,4-disubstituted pyrimidines through sequential nucleophilic aromatic substitutions.
专利号:US-6608199-B2 优先权日:2000-07-07 标题 :Synthesis of chlorinated pyrimidines 发明人:DOYLE TIMOTHY JOHN; BENKE ALAN HENRY; WEHRENBERG PETER KARL; NADY LOUIE AKOS 权利人:SYNGENTA LTD 摘要:The invention provides a process for synthesizing chlorinated pyrimidines. The process includes reacting imidoyl chloride compounds with phosgene (COCl2). The imidoyl chloride compounds can be supplied as starting materials or can be produced by reacting organic amides with phosgene or reacting organic nitrites with hydrogen chloride. The chlorinated pyrimidines, such as 4,6-dichloropyrimidine, can be used to synthesize other compounds useful in a variety of compositions, such as fungicides, pesticides, and pharmaceuticals.
专利号:US-6982331-B2 优先权日:2001-06-08 标 题 :Synthesis of chlorinated pyrimidines 发明人:DOYLE TIMOTHY J; BENKE ALAN H; WEHRENBERG PETER K; NADY LOUIE A; RODRIGUEZ GILBERT 权利人:SYNGENTA CROP PROT INC 摘要:The invention provides a process for synthesizing chlorinated pyrimidines. The process includes reacting imidoyl chloride compounds with phosgene (COCl 2 ). The imidoyl chloride compounds can be supplied as starting materials or can be produced by reacting organic amides with phosgene or reacting organic nitrites with hydrogen chloride. Phosgene may be replaced by equivalent reagents. The chlorinated pyrimidines, such as 4,6-dichloropyrimidine, can be used to synthesize other compounds useful in a variety of compositions, such as fungicides, pesticides, and pharmaceuticals.
专利号:US-2004054181-A1 优先权日:2001-06-08 标 题:Synthesis of chlorinated pyrimidines
专利号:US-10005737-B2 优先权日:2013-10-07 标题:Methods of regioselective synthesis of 2,4-disubstituted pyrimidines
专利号:US-2015099875-A1 优先权日:2013-10-07 标题:Methods of regioselective synthesis of 2,4-disubstituted pyrimidines
参考文献:10.1055/s-0037-1609906 摘要:Goi T, Fukase K. Highly Efficient Coupling of Unstable Bicyclic Pyrimidines and Pyrazoles under Basic Conditions, and its Application to the Synthesis of Pharmaceutical Compounds. Synlett. 2018 Jul 31;29(14):1867–70. doi: 10.1055/s-0037-1609906.