CAS: 5751-80-4; Ethyl Thiophene-3-Carboxylate

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3-thiophene carboxylic acid chloride ethanol 3-Bromothiophene carbon monoxide5-ethyl-thiophene-3-carboxylic acid ethyl 2,5-diphenyl-3-thiophenecarboxylate ethyl 2,5-bis(4-methoxyphenyl)-3-thiophenecarboxylate 54H84O6S3Si3C54H84O6S3Si3

3-噻吩甲酸置于硫酸体系中,用 乙醇 作为反应溶剂,以88%的收率获得产物噻吩-3-甲酸乙酯
参考文献:苯并噻唑类化合物及医药用途
标题:苯并噻唑类化合物及医药用途
摘要:本发明公开了一种苯并噻唑类化合物及其医药用途,具体涉及如式i所示的苯并噻唑类化合物及其医药用途,尤其涉及苯并噻唑类化合物作为usp7C端结构域调控剂在预防和治疗骨髓增生异常综合征及恶性肿瘤的药物中的用途.本发明式i所示苯并噻唑类化合物或其药学上可接受的盐或溶剂化物与usp7C端蛋白具有很强的结合力,并可以降低肿瘤细胞中dnmt1的蛋白水平,因而可应用在制备usp7调控剂,同时具有显著的抗肿瘤细胞增殖作用,可以用于制备预防或治疗骨髓增生异常综合征及恶性肿瘤的药物.

专利信息

专利号:US-6051704-A
优先权日:1996-07-22
标题:Synthesis of macrocyclic tetraamido-N ligands
发明人：GORDON-WYLIE SCOTT W; COLLINS TERRENCE J
权利人:UNIV CARNEGIE MELLON
摘要:New synthetic methods for the preparation of macrocyclic amido-N donor ligands are provided. The primary method of the present invention involves in general only two synthetic steps. In the first step, an α or β amino carboxylic acid is allowed to react with an optimal (approximately stoichiometric) amount of an activated malonate or oxalate derivative with mild heating. Upon completion of the double coupling reaction, hydrolysis of the reaction mixture yields a diamide containing intermediate (a macro linker). In the second step, stoichiometric amounts of a diamine, preferably an orthophenylene diamine, are added to the macro linker intermediate in the presence of a coupling agent and heat. This second double coupling reaction, is allowed to proceed for a period of time sufficient to produce a macrocyclic tetraamido compound. The substituent groups on the α or β amino carboxylic acid, the malonate, and the aryl diamine may all be selectively varied so that the resulting tetraamido macrocycle can be tailored to specific desired end uses. The macrocyclic tetraamide ligand may then be complexed with a metal, such as a transition metal, and preferably the middle and later transition metals, to form a robust chelate complex suitable for catalyzing oxidation reactions.

专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

专利号:US-9487539-B2
优先权日:2009-09-18
标 题 :Compounds and therapeutic use thereof for protein kinase inhibition
发明人：WU ZHANGGUI
权利人:WU ZHANGGUI
摘要:Novel compound having the following formula: n nwherein Y is N, O, or S. Also disclosed are a pharmaceutical compositions comprising the same, methods for treating cancer using the same, and methods for the synthesis of the same. The novel compounds of the present invention are found to inhibit protein kinases, especially Checkpoint kinase Chk1/Chk2.

专利号:WO-2018170851-A1
优先权日:2017-03-23
标题 :Imide-containing ladder tpye heteroarenes: synthesis and ralated organic semiconductor devices
发明人：GUO XUGANG; WANG YINGFENG; GUO HAN; LING SHAOHUA
权利人:UNIV SOUTH SCIENCE & TECHNOLOGY CHINA
摘要:Small molecule and polymer semiconductors and their preparation methods are provided. These compounds are of formula I-III, and can be used in high-mobility organic thin-film transistors and bulk heterojunction polymer solar cells.

专利号:US-2004167329-A1
优先权日:2003-02-21
标 题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process

专利号:CN-106749318-A
优先权日:2016-11-22
标题:A kind of organic field effect transistor material based on oxygen heterofused rings and its synthesis method and application