CAS: 598-72-1; Dl-2-Bromopropionic

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CAS号619-73-8 对硝基苯甲醇 | CAS号584-08-7 碳酸钾 | CAS号3674-13-3 2,3-二溴丙酸乙酯 | CAS号302-72-7 DL-2-氨基丙酸 | CAS号13195-80-7 1,1-二溴-1-丙烯 | CAS号849585-22-4 2-羟基丙酸 | CAS号5445-17-0 2-溴丙酸甲酯 | CAS号558-13-4 四溴化碳 | CAS号104976-82-1 2-[4-(1-carboxy... | CAS号10470-82-3 2-(2-萘氧基)丙酸 | CAS号110699-22-4 2-[4-[4-(1-carb... | CAS号5445-17-0 2-溴丙酸甲酯 | CAS号32644-15-8 2-溴丙酸 | CAS号10009-70-8 (R)-(+)-2-溴丙酸 | CAS号34522-32-2 章鱼碱 | CAS号63358-47-4 (+)-4-CHLOROTAR... | CAS号5555-13-5 2-(4-二苯氧基)丙酸

丙酸置于溴,三氯化磷体系中,化学反应 15.0H,反应生成 2-溴丙酸
参考文献:中离子 5-Alkyl-1,3-Dithiolium-4-Thiolates:合成和盐水对虾的毒性
标题:中离子 5-Alkyl-1,3-Dithiolium-4-Thiolates:合成和盐水对虾的毒性
摘要:合成并表征了一系列 12 种 1,3-Dithiolium-4-Thiolate 介离子化合物.以α-溴代链烷酸为原料合成2-N-吗啉代-二硫代氨基甲酰基羧酸,在甲胺中与二硫化碳和乙酸酐反应反应生成相应的2-N-吗啉代-二硫代氨基甲酰羧酸,未分离出中间体1,3-二硫鎓-4-油酸酯.之后,通过逆向 1,3-偶极加成反应获得 2-N-Morpholino-5-烷基-1,3-Dithiolium-4-Thiolates.醇!与杂环的 C-5 连接的部分允许增加疏水特性,并且对卤虫的致死率评估了这种影响.结果表明,介离子衍生物侧链碳原子数与丰年虾毒性测定的ld50呈钟形关系.介离子化合物因其特殊的结构,反应行为和广谱性而受到越来越多的关注和广泛的研究.-范围的生物活动 (1-5).最近,这些化合物已被广泛用于新材料应用,包括非线性光学效应 (6),分析试剂 (7)(例如 Nitron")和照相材料
DOI:10.1515/hc.2002.8.6.593

专利信息

专利号:US-5977301-A
优先权日:1992-09-24
标题 :Synthesis of N-substituted oligomers
发明人：ZUCKERMAN RONALD N; KERR JANICE M; KENT STEPHEN B H; MOOS WALTER H; SIMON REYNA J; GOFF DANE A
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a resin-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability.

专利号:EP-0671928-B1
优先权日:1992-09-24
标题 :Synthesis of n-substituted oligomers
发明人：ZUCKERMANN RONALD N; KERR JANICE M; KENT STEPHEN BRIAN HENRY; MOOS WALTER H; SIMON REYNA J; GOFF DANE A
权利人:CHIRON CORP
摘要:Poly N-substituted Glycines (poly NSGs), wherein the substituents bear purine or pyrimidine bases (R<9>) every second glycine: In addition, a solid phase method for the synthesis of N-substituted oligomers of more general structures is disclosed.The poly NSGs obtainable by this method can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a resin-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using the automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability.

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:US-4288608-A
优先权日:1978-06-01
标题:Synthesis of anthracyclines
发明人：JOHNSON FRANCIS; KIM KYOUNG S
权利人:RESEARCH CORP
摘要:There is provided a novel method of synthesizing certain heterocyclic quinones. In particular there is provided a novel and regiospecific synthesis of 9-acetyl-6,11-dihydroxy-4-methoxy-7,8,9,10-tetrahydronaphthacene-5,12-quinone (7,9-dideoxydaunomycinone) which is known intermediate in the synthesis of daunomycinone. There is also provided a method of preparing analogs of 7,9-dideoxydaunomycinone which thus provide for the preparation of known and desired analogs of daunomycinone. Daunomycinone is a known compound which is an intermediate in the preparation of the clinically accepted naturally-occurring antitumor antibiotics daunomycin and its derivitive adriamycin.

专利号:US-8110021-B2
优先权日:2008-07-28
标题:Synthesis of PtCo nanoparticles
发明人：ZHONG CHUAN-JIAN; LUO JIN; XU ZHICHAUN; HE TING
权利人:ZHONG CHUAN-JIAN; LUO JIN; XU ZHICHAUN; HE TING; HONDA MOTOR CO LTD; UNIV NEW YORK STATE RES FOUND
摘要:Synthesis of nanoparticles with particle size control is provided by the method of using two different metal-containing precursors, a capping component, an optional reducing agent, and then contacting the two precursors with the capping component to form a reaction solution, which is heated to produce first and second metals-containing nanoparticles. By controlling the ratio of the concentration of the capping component to the total concentration of the two metal-containing precursors, the nanoparticles can have diameters ranging between about 1 nm to about 15 nm. A decrease in the concentration of the capping component typically increases the size of the nanoparticles. Preferred compositions include Pt and Co-containing alloy nanoparticles. Controlled synthesis of larger, about 6 nm to about 12 nm, sized nanoparticles can be achieved in a solvent-free reaction process.

专利号:US-5545568-A
优先权日:1992-09-14
标题:Solid phase and combinatorial synthesis of compounds on a solid support
发明人：ELLMAN JONATHAN A
权利人:UNIV CALIFORNIA
摘要:Methods, compositions, and devices for synthesizing combinatorial libraries of various useful compounds, such as benzodiazepines, prostaglandins, β-turn mimetics and glycerol-derived drugs is described. In order to expediently synthesize such combinatorial libraries of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.