CAS: 72914-19-3; 4,4'-Di-Tert-Butyl-2,2'-Bipyridine

上下游产品

CAS号81167-60-4 4-(叔丁基)-2-氯吡啶 | CAS号3978-81-2 4-叔丁基吡啶 | CAS号1187755-05-0 2,10-di-tert-bu...

6-Dimethylamino-2,10-Di-Tert-Butyldipyrido[1,2-C,2',1'-E]Imidazolium Chloride置于水,Potassium Hydride,Sodium Hydroxide体系中,用 乙腈 作为反应溶剂,化学反应 1.5H,反应生成 4,4'-二叔丁基-2,2'-二吡啶
参考文献:Reduction Of Dipyrido Ureas Via 6-Alkyloxydipyrido[1,2-C;2´,1´-E]Imidazolium Salts
标题:Reduction Of Dipyrido Ureas Via 6-Alkyloxydipyrido[1,2-C;2´,1´-E]Imidazolium Salts
摘要:二嘧啶尿嘧啶盐可通过使用meerwein试剂烷基化二嘧啶尿嘧啶而轻松合成.与相应的尿嘧啶相比,尿嘧啶盐对碱性或还原剂(如金属氢化物)更具反应性.反应性研究表明,尿嘧啶盐可以作为烷基化试剂对二甲基亚砜(dmso),Dbu和naoet进行反应,并释放相应的二嘧啶尿嘧啶.相反,在干燥去气乙腈中,用硼氢化钠或三甲氧基硼氢化钠还原二嘧啶尿嘧啶会以中等产率反应生成咪唑盐7A和7B.副产物分析显示,可能发生原位卡宾形成,可以通过使用去气但潮湿的乙腈作作为反应溶剂来逆转.通过这些方法,7B的产率显著增加.
DOI:10.1515/znb-2010-0711

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-2021107859-A1
优先权日:2018-04-06
标题 :A process for the synthesis of carbon labeled organic compounds
发明人：AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.

专利号:US-2015336866-A1
优先权日:2013-01-01
标题:Synthesis of difluoromethyl ethers and sulfides
发明人：HARTWIG JOHN; FIER PATRICK
权利人:UNIV CALIFORNIA
摘要:The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone-depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

专利号:US-12331021-B2
优先权日:2020-09-10
标题 :Total synthesis of pirfenidone
发明人：ZHOU LIHUA
权利人:SUZHOU FUDE ZHAOFENG BIOCHEMICAL TECH CO LTD
摘要:The present invention relates to a process for the synthesis of Pirfenidone (1) from 5-Methyl-3,4-dihydro-2-pyridone and halobenzene (chlorobenzene, bromobenzene, or iodobenzene) in the presence of a catalytic system consisting of a copper salt and an organic ligand, in the presence of a base.

专利号:US-6958420-B2
优先权日:2002-07-19
标题:Synthesis of aminoarylboronic esters and substituted anilines from arenes via catalytic C-H activation/borylation/amination and uses thereof
发明人：MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL
权利人:UNIV MICHIGAN STATE
摘要:A process is described for synthesizing aminoarylboronic esters of the general formula n n nwherein R, R 2 , and R 3 are each an alkyl, aryl, vinyl, alkoxy, carboxylic esters, amides, or halogen; Ar is any variety of phenyl, naphthyl, anthracyl, heteroaryl; and R 1 is alkyl, hydrogen, or aryl. The aminoarylboronic esters are produced via the metal-catalyzed coupling of arylboronic esters of the general formula n n nwherein R and R 1 are any non-interfering group and X is chloro, bromo, iodo, triflates, or nonaflates to amines (primary and secondary). In particular, a process is described for the synthesis of the aminoarylboronic esters via a step-wise or tandem process in which one catalytic event is a metal-catalyzed borylation and the other catalytic event is a metal-catalyzed amination.

专利号:US-2023357286-A1
优先权日:2020-07-24
标 题:Ketone synthesis and applications
发明人：KISHI YOSHITO; UMEHARA ATSUSHI
权利人:HARVARD COLLEGE
摘要:Provided are new nickel./zirconium-mediated coupling reactions useful in the synthesis of ketone-containing compounds, e.g., halichondrin natural products and related molecules. A feature of the present disclosure is the use of a nickel(I) catalyst in tandem with a nickel (II) catalyst in the Ni/Zr-mediated coupling reactions. Without wishing to be bound by any particular theory, the nickel (I) catalyst selectively activates the electrophilic coupling partner (i.e., the compound of Formula (A)), and the nickel(ll) catalyst selectively activates the nucleophilic coupling partner (i.e., a thioester of Formula (B)). This dual catalyst system leads to improved coupling efficiency and eliminates the need for a large excess of one of the coupling partners (i.e., a compound of Formula (A) or (B)).