CAS: 98-50-0; Arsanilic Acid

该化合物是有机酸化合物,其特点是芳香结构,包括氨基组(-NH2)和含砷功能组,看起来像白色至黄晶状固体,在水中可溶解,在各种应用中有用;该化合物主要以其历史上在兽医医学中的用途而闻名,特别是作为牲畜生长促进剂和其他含砷化合物合成物;氨基和有机酸化合物的典型特性,包括潜在的毒性和因砷记录良好的有害影响而引起的环境关切;其化学公式为C7H10N2O2As,表明碳,氢,氮,氧和砷的存在;由于含有砷含量,处理氨酸需要谨慎小心,而且在许多区域受到监管检查;

⚠️危险化学品目录(2015年版) 急性毒性-经口,类别3*
英文名称Arsanilic Acid
中文名称对氨基苯砷酸
IUPAC名称Arsanilic acid
其它别名Arsanilicacid (8CI); Arsonic acid, (4-aminophenyl)- (9CI); (p-Aminophenyl)arsonic acid; 4-Aminobenzenearsonic acid; 4-Aminophenylarsonic acid; 4-Arsanilic acid; 4-Arsonoaniline; Aminophenylarsine acid; Atoxylicacid; Pro-gen; Pro-gen 90; p-Aminobenzenearsonicacid; p-Anilinearsonic acid; p-Arsanilic acid; p-Arsonoaniline
CAS编号98-50-0
MFCD编号:MFCD00007819
EINECS号:202-674-3
FDA UNII编号:UDX9AKS7GM
分子式:C6H8AsNO3
分子量:217.05
产品CID: 2026576
同类组份化合物CAS98-50-0 (free acid)6696-54-4 (sodium hydrate)
产品分类原料药 → 饲料药物添加剂

相似结构搜索
产品信息参考;;;;
InChIKey: XKNKHVGWJDPIRJ-UHFFFAOYSA-N
InChI=1S/C6H8AsNO3/c8-6-3-1-5(2-4-6)7(9,10)11/h1-4H,8H2,(H2,9,10,11)…
计算化学: 氢键受体数4.0氢键供体数3.0可旋转键数1.0

物理性质

熔点≥300 °C(文献)
沸点528.5±52.0 °C at 760 mmHg
闪点273.4±30.7 °C
密度1.9571
pKa:pK1: ca 2;pK2: 4.02;pK3: 8.62 (25°C)
PSA:83.55
LogP:-1.28
蒸汽压0.0±1.5 mmHg at 25°C
溶解性Sparingly Soluble In Water, Soluble In Concentrated Mineral Acids, Alkali Carbonate Solutions, Alcohol And Diethyl Ether. Practically Insoluble In Acetone, Benzene And Chloroform.
敏感性避免与强氧化剂接触。
外观形态水溶液中析出的针状物固体
储存条件储存于阴凉、通风的库房。远离火种、热源。包装密封保存。应与氧化剂分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。
产品应用用于医药制造及用作测定铵,铈,锆的试剂.
性质描述该品为白色针状晶体,熔点232°C,相对密度1.957.溶于热水,戊醇,碳酸碱溶液及浓矿酸,微溶于冷水,乙醇及乙酸,不溶于稀矿酸,微溶于冷水,乙醇及乙酸,不溶于稀酸,丙酮,苯和氯仿.

MSDS等安全信息

GHS象形图
GHS符号GHS06 & GHS09;
注释: Skull and crossbones & Environment
危险类别致癌性类别1A
急性毒性类别3(吸入)
急性毒性类别3(经口)
水生急性毒性类别1
水生慢性毒性类别1
警示词Danger(危险)
危险描述H350 |可能致癌.
H331 |吸入会中毒.
H301 |吞咽会中毒.
H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响.
防范说明P273-P301+P310+P330-P304+P340+P311
危险等级6.1
UN编号UN 3465 6.1/PG 3
危险品标志T,N
包装等级III
安全声明20/21-28-45-60-61-28A
危险类别码23/25-50/53
WGK Germany3

欧盟法规

《欧盟PIC法规》ECHA物质ECHA物质OtherC&L通报REACH预注册

上下游产品

合成工艺路线路线简述

合成目标产物 4-Aminophenylarsonic Acid 主要起始原料 4-Nitrobenzenediazonium
(文献来源)合成步骤主要原料 4-Nitrobenzenediazonium

Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于碘,溶剂黄146体系中,化学反应生成对氨基苯砷酸
参考文献:Ehrlich; Bertheim,Chemische Berichte,1911,Vol. 44,P. 1262
标题:Ehrlich; Bertheim,Chemische Berichte,1911,Vol. 44,P. 1262

专利信息

专利号:US-9768333-B2
优先权日:2009-02-03
标题:Microbially-mediated method for synthesis of non-oxide semiconductor nanoparticles
发明人：PHELPS TOMMY J; LAUF ROBERT J; MOON JI-WON; RONDINONE ADAM JUSTIN; LOVE LONNIE J; DUTY CHAD EDWARD; MADDEN ANDREW STEPHEN; LI YILIANG; IVANOV ILIA N; RAWN CLAUDIA JEANETTE
权利人:UT BATTELLE LLC; UNIV TENNESSEE RES FOUND
摘要:The invention is directed to a method for producing non-oxide semiconductor nanoparticles, the method comprising: (a) subjecting a combination of reaction components to conditions conducive to microbially-mediated formation of non-oxide semiconductor nanoparticles, wherein said combination of reaction components comprises i) anaerobic microbes, ii) a culture medium suitable for sustaining said anaerobic microbes, iii) a metal component comprising at least one type of metal ion, iv) a non-metal component comprising at least one non-metal selected from the group consisting of S, Se, Te, and As, and v) one or more electron donors that provide donatable electrons to said anaerobic microbes during consumption of the electron donor by said anaerobic microbes; and (b) isolating said non-oxide semiconductor nanoparticles, which contain at least one of said metal ions and at least one of said non-metals. The invention is also directed to non-oxide semiconductor nanoparticle compositions produced as above and having distinctive properties.

专利号:US-8759053-B2
优先权日:2009-02-03
标题 :Microbially-mediated method for synthesis of non-oxide semiconductor nanoparticles
发明人：PHELPS TOMMY J; LAUF ROBERT J; MOON JI WON; RONDINONE ADAM J; LOVE LONNIE J; DUTY CHAD EDWARD; MADDEN ANDREW STEPHEN; LI YILIANG; IVANOV ILIA N; RAWN CLAUDIA JEANETTE
权利人:PHELPS TOMMY J; LAUF ROBERT J; MOON JI WON; RONDINONE ADAM J; LOVE LONNIE J; DUTY CHAD EDWARD; MADDEN ANDREW STEPHEN; LI YILIANG; IVANOV ILIA N; RAWN CLAUDIA JEANETTE; UT BATTELLE LLC; UNIV TENNESSEE RES FOUNDATION
摘要:The invention is directed to a method for producing non-oxide semiconductor nanoparticles, the method comprising: (a) subjecting a combination of reaction components to conditions conducive to microbially-mediated formation of non-oxide semiconductor nanoparticles, wherein said combination of reaction components comprises i) anaerobic microbes, ii) a culture medium suitable for sustaining said anaerobic microbes, iii) a metal component comprising at least one type of metal ion, iv) a non-metal component containing at least one non-metal selected from the group consisting of S, Se, Te, and As, and v) one or more electron donors that provide donatable electrons to said anaerobic microbes during consumption of the electron donor by said anaerobic microbes; and (b) isolating said non-oxide semiconductor nanoparticles, which contain at least one of said metal ions and at least one of said non-metals. The invention is also directed to non-oxide semiconductor nanoparticle compositions produced as above and having distinctive properties.

专利号:WO-2012030642-A2
优先权日:2010-09-02
标题:Microbially-mediated method for synthesis of non-oxide semiconductor nanoparticles

专利号:US-2010330367-A1
优先权日:2009-02-03
标题:Microbially-mediated method for synthesis of non-oxide semiconductor nanoparticles

专利号:US-2010193752-A1
优先权日:2009-02-03
标题 :Microbially-mediated method for synthesis of non-oxide semiconductor nanoparticles

专利号:TW-358099-B
优先权日:1991-12-02
标题 :Process for the synthesis of crysteamine melaminylthioarsenate dihydrochloride or melarsomine dyhydro-chloride

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主要参考文献

1: Lu Y, Yuan H, Deng S, Wei Q, Guo C, Yi J, Wu J, Li R, Wen L, He Z, Yuan L. Arsanilic acid causes apoptosis and oxidative stress in rat kidney epithelial cells (NRK-52e cells) by the activation of the caspase-9 and -3 signaling pathway. Drug Chem Toxicol. 2014 Jan;37(1):55-62. doi: 10.3109/01480545.2013.806532. Epub 2013 Jul 12. doi: 10.1016/j.chemosphere.2013.12.060. Epub 2014 Jan 6. Epub 2013 Oct 18.
4: Czaplicka M, Jaworek K, Bąk M. Study of photodegradation and photooxidation of p-arsanilic acid in water solutions at pH =
7: kinetics and by-products. Environ Sci Pollut Res Int. 2015 Nov;22(21):16927-35. doi: 10.1007/s11356-015-4890-z. Epub 2015 Jun 25. doi: 10.1002/jat.2726. Epub 2012 Mar 9. doi: 10.1021/es505358c. Epub 2015 Feb 24. doi: 10.1080/09593330.2015.1025105. Epub 2015 Apr 1. doi: 10.1021/jp504710b. Epub 2014 Jul 18. doi: 10.1016/j.talanta.2012.05.057. Epub 2012 Jun 12. Epub 2010 Oct 7. doi: 10.1007/s10565-015-9300-2. Epub 2015 Apr 19. doi: 10.1021/acs.est.5b05619. Epub 2016 Feb 26. doi: 10.1016/j.jhazmat.2012.05.078. Epub 2012 May 28. Chinese. Chinese. Chinese. doi: 10.1016/j.jcis.2011.02.040. Epub 2011 Feb 24. doi: 10.1016/j.jes.2016.01.017. Epub 2016 Mar 5. doi: 10.1016/j.watres.2015.11.037. Epub 2015 Nov 22.

合成参考文献

摘要:Journal of Pharmacology and Experimental Therapeutics., 80(393), 1944
摘要:Journal of Chemotherapy and Advanced Therapeutics., 11(34), 1934
摘要:USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present
摘要:WHO; Environ Health Criteria 18: Arsenic p.73 (1981)
摘要:Lide, D.R., G.W.A. Milne (eds.). Handbook of Data on Organic Compounds. Volume I. 3rd ed. CRC Press, Inc. Boca Raton ,FL. 1994., p. V1 311

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