CAS: 112883-40-6; Fmoc-D-Met-Oh

相似化合物

71989-28-1 1152-62-1 2488-15-5

上下游产品

(fluorenylmethoxy)carbonyl chloride N-Fm°C-methionine DL-methionine2O-W-F-I-M-H(1-Bzl)-NH2 2O-W-M-I-F-H(1-Bzl)-NH2 2O-W-F-M-F-H(1-Bzl)-NH2 51H54Cl3N3O7S2C51H54Cl3N3O7S2

Dl-蛋氨酸置于sodium Carbonate,三氟乙酸体系中,用 1,4-二氧六环,正己烷,水,异丙醇 用作溶剂,化学反应 5.0H,反应生成Fmoc-L-蛋氨酸,Fmoc-D-蛋氨酸
参考文献:使用直链淀粉衍生的手性固定相测定作为n-芴基甲氧基羰基衍生物的α-氨基酸及其甲基酯的化学和对映体纯度
标题:使用直链淀粉衍生的手性固定相测定作为n-芴基甲氧基羰基衍生物的α-氨基酸及其甲基酯的化学和对映体纯度
摘要:在衍生自直链淀粉衍生物的三个共价键合型手性固定相(csp)上进行液相色谱对映体分离,同时测定α-氨基酸及其甲酯作为n-芴基甲氧基羰基(fmoc)衍生物的化学和对映体纯度.作为n-Fmoc衍生物的α-氨基酸酯的对映体分离要好于相应的酸,尤其是对于csp 1和2.对于一些市售消旋氨基酸甲酯中存在的化学杂质,如相应的消旋酸,观测到是0.49-17.50%.发现几种可商购的l-氨基酸甲酯的对映体杂质为0.03-0.58%,而相同分析物中存在的相应消旋酸的化学杂质为0.13-13.62%.
Doi:10.1002/bkcs.11694

专利信息

专利号:US-2025231184-A1
优先权日:2022-10-12
标题:Nitrilotriacetic acid linkers, solid phase synthesis of nitrilotriacetic acid linkers and applications thereof
发明人：JAMALI HOJJAT S
权利人:NICOYA LIFESCIENCES INC
摘要:Described are devices, compounds and methods for detecting an analyte in a sample. More particularly this disclosure provides SPR and LSPR sensors modified by NTA linkers for binding a ligand and/or analyte. The NTA linkers of the disclosure typically include a head (or “anchoring siteâ€?) for coupling to a surface of the SPR or LSPR sensor, a spacer, and one or more attachment sites on a distal end or ends of the spacer which couple to a ligand. The head may include a thiol for coupling the linker to a surface of the SPR or LSPR sensor. The spacer may be a carbon chain. PAG or PEG chain, or matrix material. The one or more attachment sites may be a nitrilotriacetic acid (NTA) moiety capable of chelating a transition metal ion and binding the ligand.

专利号:US-8410028-B2
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries
发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

专利号:US-2021171437-A1
优先权日:2017-07-17
标题 :Peptide nucleic acid (pna) monomers with an orthogonally protected ester moiety and novel intermediates and methods related thereto
发明人：COULL JAMES M; GILDEA BRIAN D
权利人:VERA THERAPEUTICS INC
摘要:The present disclosure pertains to peptide nucleic acid (PNA) monomers and oligomers, as well as methods and compositions useful for the preparation of PNA monomer precursors (e.g. PNA Monomer Esters, Backbone Esters and Backbone Ester Acid Salts, as described below) that can be used to prepare PNA monomers wherein said PNA monomers can be used to prepare said PNA oligomers. In some embodiments, the disclosure features sulfonic acid salts of Backbone Ester compounds, which sulfonic acid salts generally tend to be crystalline and can be obtained in reasonably good yield, often without requiring any chromatographic purification of the reaction product of the Backbone Ester synthesis reaction. This disclosure also pertains to novel methods for the synthesis of said Backbone Ester compounds and novel methods for the formation of the related sulfonic acid salts. Exemplary ester groups include, but are not limited to, 2,2,2-trichloroethy-(TCE), 2,2,2-tribromoethyl-(TBE), 2-iodoethyl-groups (2-IE) and 2-bromoethyl-(2-BrE) as the ester group. These particular ester groups can be removed under conditions where both Boc and Fmoc protected amine groups are stable.

专利号:US-2007042401-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries

专利号:EP-4602368-A1
优先权日:2022-10-12
标 题 :Nitrilotriacetic acid linkers, solid phase synthesis of nitrilotriacetic acid linkers and applications thereof

专利号:US-2012245040-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries