CAS: 28292-43-5; 5-Methylhexan-2-Amine

5-甲基-2-己酮置于磷酸吡哆醛,(R)-Selective Transaminase Rhodobacter Sp. 140 A (Rbta) Recombinant,异丙胺体系中,用 Aq. Buffer 用作溶剂,化学反应 2.0H,反应生成2-氨基-5-甲基己烷
参考文献:手性羟基胺不对称合成中(R)-选择性转氨酶的生化和结构表征
标题:手性羟基胺不对称合成中(R)-选择性转氨酶的生化和结构表征
摘要:鉴定出一种 ( R ) 选择性转氨酶rb Ta,在羟基酮的不对称胺化中具有出色的立体选择性 (>99% Ee ).生化表征表明,Rb Ta 在报道的酶中对 4-羟基-2-丁酮表现出最高的活性,并且它具有广泛的底物特异性,包括脂肪族,芳香族和脂环族酮.进行了rb Ta 的结晶,以及分子对接和诱变研究.残基 Tyr125 通过与羟基酮形成氢键在底物识别中起关键作用.该酶在制备规模合成(R)-3-氨基-1-丁醇,证明了rb Ta 作为生产高附加值手性羟基胺的绿色生物催化剂的潜力.该研究为手性羟基胺的酶促合成提供了一种有效的工具,并提供了对羟基酮不对称胺化中转氨酶对底物识别的结构洞察.
Doi:10.1002/adsc.202100636

专利信息

专利号:US-12312325-B2
优先权日:2022-03-01
标 题:Methods and compounds useful in the synthesis of an AAK1 inhibitor
发明人：CHEN TAO; WU WENXUE; YAN JUN; ZENG XIANGLU; ZHAO MATTHEW MANGZHU
权利人:LEXICON PHARMACEUTICALS INC
摘要:Methods for the synthesis of (S)-1-((2′,6-bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine and salts thereof are disclosed, as well as compounds useful therein.

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

专利号:US-2017246690-A1
优先权日:2014-06-20
标 题:Stabilizing agent-free metal nanoparticle synthesis and uses of metal nanoparticles synthesized therefrom
发明人：MURPHY RYAN J; DREYFUS REMI; HOUGH LAWRENCE ALAN; MALASSIS LUDIVINE; MURRAY CHRISTOPHER; DONNIO BERTRAND
权利人:RHODIA OPERATIONS; CENTRE NAT RECH SCIENT; UNIV PENNSYLVANIA
摘要:Described herein are methods of synthesizing metal nanoparticles and the metal nanoparticles synthesized therefrom. Further described in the present disclosure are methods of modifying the surfaces of metal nanoparticles and the metal nanoparticles modified thereby. Also described herein are uses of such metal nanoparticles.

专利号:US-10125226-B2
优先权日:2013-06-05
标 题 :Scale-up process of bifunctionalized triblock copolymers with secondary and tertiary amines, with application in dewatering and desalting of heavy crude oils
发明人：FLORES SANDOVAL CESAR ANDRES; FLORES OROPEZA EUGENIO ALEJANDRO; LOPEZ ORTEGA ALFONSO; HERNANDEZ CORTEZ JOSE GONZALO; ESTRADA BUENDIA ARISTEO; CASTRO SOTELO LAURA VERONICA; REYES MARTINEZ REYNA; ALVAREZ RAMIREZ FERNANDO; ESTRADA MARTINEZ ARQUIMEDES; VAZQUEZ MORENO FLAVIO SALVADOR
权利人:MEXICANO INST PETROL
摘要:A chemical synthesis process is provided for the functionalization of monodispersed triblock copolymer (POEw-POPy-POEw) with secondary or tertiary amines at a semi-industrial level in glass reactors having a capacity between 1 L and 100 L. The process includes two stages where the first stage uses an alkylsulfonyl or arylsulfonyl chloride to obtain better leaving groups, and the second stage is the nucleophilic substitution with secondary or tertiary amines, to obtain the bifunctionalized triblock copolymers. The main advantage for this process is to reduce the quantity of unitary process done in each stage, the optimization of reaction times, and the stoichiometric relationships.

专利号:CN-106852132-A
优先权日:2014-06-20
标题:Stabilizer-free synthesis of metal nanoparticles and use of metal nanoparticles synthesized therefrom

专利号:US-2025282747-A1
优先权日:2022-03-01
标题:Methods and compounds useful in the synthesis of an aak1 inhibitor