CAS: 30071-93-3; 1-(3,5-Bis(Trifluoromethyl)Phenyl)Ethanone

上下游产品

CAS号328-70-1 1,3-双(三氟甲基)-5-溴苯 | CAS号401-96-7 3,5-bis-trifluo... | CAS号594-27-4 四甲基锡 | CAS号68120-60-5 (R)-1-[3,5-bis(... | CAS号108-24-7 乙酸酐 | CAS号75-36-5 乙酰氯 | CAS号402-31-3 间二三氟甲苯 | CAS号725-89-3 3,5-双(三氟甲基)苯甲酸 | CAS号917-54-4 甲基锂 | CAS号785-56-8 3,5-双(三氟甲基)苯甲酰氯 | CAS号511256-36-3 (S)-N-甲基-1-[3,5... | CAS号334477-60-0 (R)-N-甲基-1-[3,5... | CAS号349-58-6 3,5-双(三氟甲基)苯酚 | CAS号368-63-8 3,5-二(三氟甲基)苯-1-醇 | CAS号225920-05-8 (S)-1-[3,5-二(三氟... | CAS号171338-27-5 (2R,3S)-2-[(1R)... | CAS号284665-40-3 4-(3,5-双三氟甲基苯基)... | CAS号67570-38-1 2-[3,5-双(三氟甲基)苯... | CAS号154258-38-5 1-[3,5-bis(trif... | CAS号287930-75-0 (2R)-4-苄基-2-[(1...

间二三氟甲苯置于1,3-二溴-5,5-二甲基海因,硫酸,异丙基氯化镁体系中,用 四氢呋喃,溶剂黄146 用作溶剂,化学反应 5.0H,反应生成3,5-双三氟甲基苯乙酮
参考文献:3,5-双(三氟甲基)苯乙酮的改进制备方法和3,5-双(三氟甲基)苯基格氏试剂制备中的安全性考虑.
标题:3,5-双(三氟甲基)苯乙酮的改进制备方法和3,5-双(三氟甲基)苯基格氏试剂制备中的安全性考虑.
摘要:开发了一种改进的高效溴化3,5-双(三氟甲基)苯.描述了从前体溴化物安全可靠地制备潜在爆炸性的3,5-双(三氟甲基)苯基格氏试剂和3-三氟甲基苯基格氏试剂的方法.反应系统筛选工具(rsst)和差热分析(dta)研究表明,这些三氟甲基苯基格氏试剂可在失去溶剂接触或适度加热的情况下爆炸.当按照本文所述的方法制备和处理时,这些格氏试剂可以安全地制备并用于高级中间体.
Doi:10.1021/jo026903N

专利信息

专利号:US-2008090274-A1
优先权日:2004-12-16
标 题 :Process For The Synthesis Of (S)-1-(3,5-Bis (Trifluoromethyl)-Phenyl-Ethan-1-Ol
发明人：MOORE JEFFREY C; TRUPPO MATTHEW D; POLLARD JENNIFER M; POLLARD DAVID J; STURR MICHAEL G
权利人:MOORE JEFFREY C; TRUPPO MATTHEW D; POLLARD JENNIFER M; POLLARD DAVID J; STURR MICHAEL G
摘要:The present invention is concerned with novel processes for the preparation of (S)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol (CAS # 30071-93-3). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6600040-B2
优先权日:2000-06-08
标 题:Process for the synthesis of (2R, 2-alpha-R, 3A)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1, 4-oxazine
发明人：BRANDS KAREL M JOS; TSAY FUH-RONG; CONRAD KAREN M; ZHAO MATTHEW M
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxazine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6350915-B1
优先权日:1999-06-11
标 题:Process for the synthesis of 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one
发明人：CVETOVICH RAYMOND
权利人:MERCK & CO INC
摘要:The present invention is concerned with a novel process for the preparation of 1-(3,5-bis(trifluromethyl)phenyl)ethan-1-one (CAS 30071-93-3). This compound is useful as an intermediate in the synthesis of therapeutic agents.

专利号:US-6395898-B1
优先权日:2000-06-09
标 题:Trans-glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
发明人：MCNAMARA JAMES M; ZHAO MATTHEW M
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxazine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6469164-B2
优先权日:2000-06-08
标题:Process for the synthesis of (2R, 2-alpha-R)-4-benzyl-2-[1-(3,5-bis (trifluoromethyl)phenyl)ethoxy]-1,4-oxazine-3-one
发明人：BRANDS KAREL M JOS; PAYACK JOSEPH F; PYE PHILIP J
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-1,4-oxazin-3-one. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6777580-B2
优先权日:1999-07-01
标题:Process for the synthesis of (R)-1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-ol by asymmetric transfer hydrogenation
发明人：DEVINE PAUL; KARL HANSEN
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.