CAS: 50-98-6; Ephedrine Hydrochloride

上下游产品

tetrachloromethane ephedrine chloroform pentachloroethaneS,2S)-2-methylamino-1-phenyl-propyl ester); hydr°Chlorideacetic acid-((1S,2S)-2-methylamino-1-phenyl-propyl ester); hydr°Chloride R,2S)-2-methylamino-1-phenyl-propylester); hydr°Chlorideacetic acid-((1R,2S)-2-methylamino-1-phenyl-propylester); hydr°Chloride RS,2RS)-2-methylamino-1-phenyl-propylester); hydr°Chlorideacetic acid-((1RS,2RS)-2-methylamino-1-phenyl-propylester); hydr°Chloride S)-2,2,3,4r-tetramethyl-5c-phenyl-oxazolidine(4S)-2,2,3,4r-tetramethyl-5c-phenyl-oxazolidine

2-氯苯丙酮置于盐酸,钾硼氢,Potassium Carbonate体系中,用 甲醇,水,苯 作为反应溶剂,-10.0~30.0 °C,50.0 Kpa 条件下,反应 10.0H,反应生成 盐酸麻黄碱
参考文献:麻黄碱或伪麻黄碱及麻黄碱或伪麻黄碱中间 体的制备方法
标题:麻黄碱或伪麻黄碱及麻黄碱或伪麻黄碱中间 体的制备方法
摘要:本发明公开了一种麻黄碱或伪麻黄碱中间体的制备方法,包括:以2‑氯代丙酰氯和苯为起始原料,在路易斯酸催化下,进行傅‑克反应,反应生成2‑氯‑1‑苯基‑1‑丙酮;将反应生成的2‑氯‑1‑苯基‑1‑丙酮,甲胺在非质子溶剂中反应反应生成2‑甲胺基‑1‑苯基‑1‑丙酮.本发明同时公开了一种制备麻黄碱或伪麻黄碱的方法.本工艺方法不再采用污染严重的三氯化磷,不再采用危险性极大并且价格昂贵的溴素.且傅‑克反应和甲胺化反应在同一个溶剂中完成,节省了公用工程的开支.从而提供了一条安全,简捷,价廉,绿色的麻黄碱和伪麻黄碱合成新工艺方法.

专利信息

专利号:EP-1828105-B1
优先权日:2004-12-22
标题:A PROCESS FOR THE PREPARATION OF R-(-)-N, ALPHA-DIMETHYLPHENETHYLAMINE (LEVMETAMFETAMINE) OR S-(+)-N, ALPHA-DIMETHYLPHENETHYLAMINE (METHAMPHETAMINE) FROM d-EPHEDRINE OR L-EPHEDRINE RESPECTIVELY
发明人：GOLLAPUDY SUBRAHMANYAM; NITTALLA VENKATA RAMANA
权利人:EMMELLEN BIOTECH PHARMACEUTICA
摘要:A process for synthesis of R-(-)-N,alpha-Dimethylphenethylamine (Levmetamfetamine, formula I), or S-(+)-N,alpha-Dimethyl phenethylamine (Methamphetamine, formula II), from d-ephedrine of formula III or l-ephedrine formula IV, the process comprising the steps of (a) acylating the d- or l-ephedrine base of formula III or formula IV with an acylating agent to make a reaction mixture containing a N-acylated ephedrines of formula V or formula VI; (b) deoxygenation of N-acylated ephedrines to make the compound of the formula VII or Formula VIII by using Raney Nickel catalyst; and (c) acid hydrolysis of the above deoxygenated products to get the levmetamfetamine or methamphetamine.

专利号:US-9707553-B2
优先权日:2011-07-11
标题 :P-chirogenic organophosphorus compounds
发明人：JUGE SYLVAIN; BAYARDON JEROME; REMOND EMMANUELLE; LAUREANO HUGO; HENRY JEAN-CHRISTOPHE; LEROUX FREDERIC; COLOBERT FRANCOISE
权利人:CENTRE NAT DE LA RECH SCIENT (CNRS); UNIV BOURGOGNE; UNIV STRASBOURG; SYNTHELOR SAS
摘要:P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). n n n n n n n n n n Metal complexes comprising compounds (I) as ligands are also described. The compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.

专利号:US-6800663-B2
优先权日:2002-10-18
标 题:Crosslinked hydrogel copolymers
发明人：ASGARZADEH FIROUZ; COSTANTINO HENRY R
权利人:ALKERMES INC
摘要:The present invention relates to crosslinked polymers, synthesized through ring-opening polymerization of ethylenically unsaturated epoxides, in combination with α-hydroxy acids using a hydrophilic macroinitiator, such as poly(ethylene glycol), to form substituted copolymers having ethylenically unsaturated functionality randomly distributed along the polyester polymer backbone. That copolymer is subsequently crosslinked to form a hydrogel network. More particularly, the present invention relates to the synthesis of biodegradable poly(α-hydroxy acid-co-glycidyl methacrylate)-block-poly(ethylene glycol)-block-poly(α-hydroxy acid-co-glycidyl methacrylate) copolymers, which are subsequently crosslinked to form hydrogel networks. The invention also relates to the use of these hydrogel networks in various applications, in particular, for the controlled release of drugs and proteins.

专利号:WO-2024040267-A2
优先权日:2022-08-19
标题 :Direct synthesis of n-(3-substituted-chroman-4-yl)-7h- pyrrolo[2,3-d]pyrimidin-4-amines and derivatives thereof

专利号:US-6403824-B2
优先权日:2000-02-22
标 题:Process for the preparation for 4,5-diamino shikimic acid derivatives
发明人：ABRECHT STEFAN; KARPF MARTIN; TRUSSARDI RENE; WIRZ BEAT
权利人:HOFFMANN LA ROCHE
摘要:The invention provides a multistep synthesis for the preparation of 4,5-diamino shikimic acid derivatives of formulawherein R1, R2, R3 and R4 are defined in the specification, starting from furan. 4,5-Diamino shikimic acid derivatives are potent inhibitors of viral neuraminidase.

专利号:TW-393472-B
优先权日:1995-05-10
标 题:The synthesis and applications of aminoester and alkylester derivatives of capsaicin