CAS: 5893-05-0; 2-(Tritylamino)Acetic Acid

该化合物是一种受保护的甘油衍生物,氨基氨基磺酸组由一个三丁基(Trt)组加以保护.这一修改增强了稳定性,防止了在peptide合成过程中出现不必要的侧面反应,使其在固相和溶相聚战略中特别有用.三丁基乙基氨基乙酸组是酸性实验室,允许在温酸条件下有选择地去保护,而不影响其他敏感功能组.三丁基丁基丁基丁酸因其高纯度,与标准的混合试剂兼容性以及有效融入复杂的peptide序列而得到珍视.其强大的保护组确保了最小的种族化,使其在精确的化学控制下,成为合成含甘油的的可靠选择.

结构式图片

相似化合物

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CAS号76-83-5 三苯基氯甲烷 | CAS号56-40-6 甘氨酸 | CAS号10065-71-1 N-三苯甲基甘氨酸甲酯 | CAS号3226-97-9 N-tritylglycine... | CAS号73488-66-1 N-trityl-glycin... | CAS号7364-42-3 N,O-bis(trimeth... | CAS号596-43-0 溴三苯基甲烷 | CAS号18514-46-0 N-(三苯甲基)甘氨酸乙酯 | CAS号5269-37-4 Glycin-trimethy... | CAS号76-84-6 三苯基甲醇 | CAS号6479-35-2 Glycine, N-trit... | CAS号86114-77-4 2-(tritylamino)... | CAS号5893-07-2 2-[[2-(tritylam... | CAS号62029-66-7 N-methyl-2-(tri...

合成工艺路线路线简述

    Trityl-Glycin-Tritylester置于甲醇体系中,用 氯仿,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 0.3H,反应生成 N-(三苯甲基)甘氨酸
    参考文献:Efficient Synthesis Ofn-Triphenylmethyl α-Amino Acids
    标题:Efficient Synthesis Ofn-Triphenylmethyl α-Amino Acids
    摘要:已开发出一种通过其三苯甲基酯2合成n-三苯甲基(trityl)α-氨基酸3的新型一锅合成方法.
    DOI:10.1055/s-1989-27195

    海关参考信息

    专利信息


    专利号:US-6448412-B1
    优先权日:1995-07-31
    标题:Methods for the preparation and characterization of multi-substituted fullerenes
    发明人:MURPHY RANDALL B; WILSON STEPHEN R; LU QUING
    权利人:SPHERE BIOSYSTEMS INC
    摘要:The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the C n fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3 He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.

    专利号:US-10723766-B2
    优先权日:2015-11-27
    标题 :Derivatives of gamma-amanitin
    发明人:WERNER-SIMON SUSANNE; LUTZ CHRISTIAN; MüLLER CHRISTOPH; SIMON WERNER
    权利人:HEIDELBERG PHARMA RES GMBH
    摘要:The invention relates to γ-amaninamide (1; x=0, 1 or 2), γ-amaninamidic acid (2; x=0, 1 or 2), and γ-amaninamidic hydroxamic acid (3; x=0, 1 or 2), novel derivatives of γ-amanitin (4), and methods and novel building blocks for the synthesis thereof.

    专利号:US-8273403-B2
    优先权日:2002-05-10
    标题 :Generation of surface coating diversity
    发明人:BARDEN MICHAEL C; KAMBOURIS PETER A
    权利人:BARDEN MICHAEL C; KAMBOURIS PETER A; BIO LAYER PTY LTD
    摘要:This invention relates to a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon which comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a copolymer (B) of at least one passive constituent (P) and at least one active constituent (A); a spacer unit (S) separating the backbone from a functional group; and a functional group (F). The methods comprise the following steps: 1) selecting a plurality of synthons so that each synthon has at least two points of diversity selected from P, A, S and F; 2) applying copolymer B onto a substrate; and 3) attaching a combination of S and F to constituent A of copolymer B. Steps 2) and 3) are performed such that different synthons are generated on localized regions of the substrate.

    专利号:WO-9636631-A1
    优先权日:1995-05-19
    标题:Multiply-substituted fullerenes and methods for their preparation and characterization
    发明人:MURPHY RANDALL B; WILSON STEPHEN R; LU QUING
    权利人:SPHERE BIOSYSTEMS INC
    摘要:The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the Cn fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.

    专利号:CN-108727269-A
    优先权日:2018-07-13
    标题 :A kind of preparation method of N(Ï„)-methyl-L-histidine derivative and its application in the synthesis of anserine

    专利号:CN-112218876-B
    优先权日:2018-04-10
    标题 :Synthesis of end-capped lixisenatide
    杭州澳立盛化学有限公司
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    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
    [参考文献]: Hiraku Onishi, Et Al. Chondroitin Sulfate-Glycyl-Prednisolone Conjugate As Arthritis Targeting System: Localization And Drug Release In Inflammatory Joints. Biol Pharm Bull. 2014;37(10):1641-9.
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