CAS: 691872-15-8; 5-Bromo-2-Nitropyridin-3-Ol

相似化合物

39903-01-0 152684-26-9 1805945-97-4

上下游产品

CAS号74115-13-2 3-溴-5-羟基吡啶

3-溴-5-羟基吡啶置于硫酸,硝酸体系中,化学反应 12.5H,以48.03%的收率获得产物5-溴-2-硝基-3-羟基吡啶
参考文献:发现和优化2-氨基吡啶衍生物作为新型和选择性jak2抑制剂.
标题:发现和优化2-氨基吡啶衍生物作为新型和选择性jak2抑制剂.
摘要:包括jak1,Jak2,Jak3和tyk2在内的janus激酶(jak)是细胞内非受体酪氨酸激酶家族的成员,已被证明在细胞信号传导途径中至关重要,并参与炎症性疾病和癌症.jak2中的v617F突变与真性红细胞增多症(pv),原发性血小板增多症(et)和骨髓纤维化(mf)有关.在这里,我们描述了一系列2-氨基吡啶衍生物的设计,合成和生物学评估.酶活性测定的结果支持了化合物16M-作为潜在的和选择性的jak2抑制剂,该化合物表现出高的抑制活性,对jak2的ic50为3 Nm,选择性分别是jak1和jak3的85倍和76倍.
DOI:10.1016/j.Bmcl.2020.127048

专利信息

专利号:WO-2023098592-A1
优先权日:2021-11-30
标题:Preparation method for carbon-loaded iron-based catalyst and use thereof in synthesis of intermediates of anti-cancer inhibitors

专利号:CN-114315595-B
优先权日:2021-11-30
标题 :Preparation method of a carbon-supported iron-based catalyst and its application in the synthesis of anti-cancer inhibitor intermediates

专利号:TW-202412791-A
优先权日:2022-08-16
标 题 :Synthesis of substituted tetracyclic carboxylic acids and analogues thereof

专利号:WO-2024038357-A1
优先权日:2022-08-16
标 题:Synthesis of substituted tetracyclic carboxylic acids and analogues thereof
发明人：CHEN SHUAI; COLE ANDREW G; GOTCHEV DIMITAR B; MASON JEREMY; PALLERLA MAHESH KUMAR; PAMULAPATI GANAPATI REDDY; SPINK JAN MICHELLE
权利人:ARBUTUS BIOPHARMA CORP
摘要:The present disclosure includes synthetic methods for preparing certain substituted tetracyclic carboxylic acids, which can be used to treat, ameliorate, or prevent hepatitis B virus (HBV) infections in a patient.

专利号:CN-114315595-A
优先权日:2021-11-30
标题:Preparation method of carbon-supported iron-based catalyst and synthesis application of anti-cancer inhibitor intermediate thereof