CAS: 86087-24-3; (R)-Tetrahydrofuran-3-Ol

• 英文名称(R)-Tetrahydrofuran-3-Ol
• 中文名称(R)-(-)-3-羟基四氢呋喃
• IUPAC名称(R)-tetrahydrofuran-3-ol
• 其它别名(R)-四氢呋喃-3-醇; R3羟基四氢呋喃; Hydroxytetrahydrofuran, (R)-(-)-3-
• CAS编号86087-24-3
• MFCD编号:MFCD00067101
• EINECS号:617-796-6
• FDA UNII编号:AUS5N27VPH
• 分子式:C4H8O2
• 分子量:88.11
• 产品CID: 1861256
• 产品分类有机原料→分子砌块→脂肪杂环类化合物→四氢呋喃类化合物

• 相似结构搜索
• InChIKey: XDPCNPCKDGQBAN-SCSAIBSYSA-N
• InChI=1S/C4H8O2/c5-4-1-2-6-3-4/h4-5H,1-3H2/t4-/m1/s1…
• 计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数0.0

相似化合物

物理性质

• 沸点181°C at 760 mmHg
• 闪点82°C
• 密度1.1±0.1 g/cm3
• PH:-18.5 º (c=2 MeOH)
• pKa:14.49±0.20(预测)
• PSA:29.46
• LogP:-0.2324
• 旋光度-18.5º(C=2MEOH)
• 折射率1.476
• 蒸汽压0.3±0.7 mmHg at 25°C
• 溶解性Chloroform, Methanol (Slightly)
• 敏感性按规定使用和贮存的不会分解，避氧化物、酰氯、酸酐、热、明火
• 外观形态透明无色液体
• 储存条件置于阴暗处,密封, 常温干燥保存
• 产品应用该化合物用于合成艾滋病毒抗体抗体的构件.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  严重眼刺激 类别2A
• 警示词Warning(警告)
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
• 防范说明P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501
• UN编号NA 1993 / PGIII
• 危险品标志Xi
• 安全声明26-36
• 危险类别码36/37/38
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 (R)-(-)-3-Hydroxytetrahydrofuran 主要起始原料 (R)-(+)-1,2,4-Butanetriol
• 100858-36-4 = 86087-24-3 [标题:Reaction Conditions
  标题:Product Class 1: Boron Compounds. Product Subclass 1: Hydroboranes
  作者:Matteson,D. S.
  参考文献:Science Of Synthesis 日期:2004 卷标:6 页码:5-79]
  
  = 86087-24-3
  反应条件:1.1 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Water
  标题:Chiral Synthesis Via Organoboranes. 19. The Successful One-Carbon Homologation Of Heterocyclic Boronate Esters With High Optical Purity
  作者:Brown,Herbert C.; Gupta,Ashok K.; Rangaishenvi,Milind V.; Prasad,J. V. N. Vara
  参考文献:Heterocycles 日期:1989 卷标:28(1) 页码:283-94]
  
  1191-99-7 = 86087-24-3
  反应条件:1.1 Reagents: Boron,Trihydro(N,1,7,7-Tetramethyl-N-Phenylbicyclo[2.2.1]Heptan-2-Amine)-,[t-4... Solvents: Benzene1.2 Reagents: Hydrochloric Acid Solvents: Tetrahydrofuran,Water1.3 Reagents: Sodium Hydroxide,Hydrogen Peroxide
  标题:Hydroboration Of Prochiral Olefins With Chiral Lewis Base-Borane Complexes: Relationship To The Mechanism Of Hydroboration
  作者:Narayana,Chatla; Periasamy,Mariappan
  参考文献:Journal Of The Chemical Society 日期:1987 卷标:(24) 页码:1857-9]
  
  1191-99-7 = 86087-24-3
  反应条件:1.1 Reagents: Bis[(1R,3R,4R,6S)-4,7,7-Trimethylbicyclo[4.1.0]Hept-3-Yl]Borane Solvents: Tetrahydrofuran1.2 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Water
  标题:Hydroboration. 83. Asymmetric Hydroboration Of Representative Cis Disubstituted And Heterocyclic Olefins With Dicaranylboranes Of High Enantiomeric Purity
  作者:Brown,Herbert C.; Prasad,J. V. N. Vara; Zaidlewicz,Marek
  参考文献:Journal Of Organic Chemistry 日期:1988 卷标:53(13) 页码:2911-16]
  
  22929-52-8 = 86087-24-3
  反应条件:1.1 Catalysts: Carbonyl Reductase Solvents: Isopropanol,Water; Ph 7,25 °C
  标题:Engineering Of Carbonyl Reductase For Asymmetric Reduction Of Difficult-To-Reduce Ketone Tetrahydrofuran-3-One
  作者:Lin,Ya-Ping; Su,Bing-Mei; Lin,Juan
  参考文献:Molecular Catalysis 日期:2023 卷标:548]
  
  1191-99-7 = 86087-24-3
  反应条件:1.1 Reagents: Bis[(1S,2R,3S,5S)-2,6,6-Trimethylbicyclo[3.1.1]Hept-3-Yl]Borane Solvents: Tetrahydrofuran1.2 Reagents: Acetaldehyde1.3 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Tetrahydrofuran
  标题:Chiral Synthesis Via Organoboranes. 6. Hydroboration. 74. Asymmetric Hydroboration Of Representative Heterocyclic Olefins With Diisopinocampheylborane. Synthesis Of Heterocyclic Boronates And Heterocyclic Alcohols Of Very High Enantiomeric Purity
  作者:Brown,Herbert C.; Prasad,J. V. N. Vara
  参考文献:Journal Of The American Chemical Society 日期:1986 卷标:108(8) 页码:2049-54]
  
  70005-88-8 = 86087-24-3
  反应条件:1.1 Catalysts: P-Toluenesulfonic Acid
  标题:Synthesis Of Enantiomerically Pure (S)-(+)-3-Hydroxytetrahydrofuran,And Its (R)-Enantiomer,From Malic Or Tartaric Acid
  作者:Tandon,Vishnu K.; Van Leusen,Albert M.; Wynberg,Hans
  参考文献:Journal Of Organic Chemistry 日期:1983 卷标:48(16) 页码:2767-9

海关参考信息

• 2905122000-异丙醇
  2905310000-1,2-乙二醇
  2905320000-1,2-丙二醇
  2905399001-1,3-丙二醇
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管