CAS: 149289-29-2; 4-(2-Amino-1-(1-Hydroxycyclohexyl)Ethyl)Phenol

该化合物是一种化学化合物,其结构特征包括环己醇混合物和附于一个含有氢氧基组的苯环上的氨基组;该化合物通常被归类为氨基酒精,表明该化合物可能具有与氨基酒精和酒精有关的特性;该羟基组的存在有助于其在极溶剂中的潜在溶解性,并可能影响其再活动,特别是在氢结合相互作用中.该氨基组可参与各种化学反应,包括核循环代用品,并可影响该化合物的生物活动.由于其结构复杂性,该化合物可能具有有趣的药用化学特性,使其成为对药用化学和酒精的兴趣对象.该化合物在生物系统中的具体应用和行为将取决于进一步的研究和定性,包括它与生物目标的相互作用及其在各种条件下的稳定.

英文名称4-(2-Amino-1-(1-Hydroxycyclohexyl)Ethyl)Phenol
中文名称1-[2-氨基-1-(4-羟基苯基)乙基]环己醇
IUPAC名称4-[2-amino-1-(1-hydroxycyclohexyl)ethyl]phenol
CAS编号149289-29-2
MFCD编号:MFCD17676369
EINECS号:812-270-4
FDA UNII编号:L00G2AX0BL
分子式:C14H21NO2
分子量:235.32204
产品CID: 719126
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: BHCUWXACHAFFSK-UHFFFAOYNA-N
1S/C14H21NO2/c15-10-13(11-4-6-12(16)7-5-11)14(17)8-2-1-3-9-14/h4-7,13,16-17H,1-3,8-10,15H2…
计算化学: 氢键受体数3.0氢键供体数3.0可旋转键数3.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 2 of 2 companies. For more detailed information, please visit ECHA C&L website.

上下游产品

1-[2-amino-1-(4-methoxyphenyl)ethyl]cyclohexanol hydr°Chloride sodium dodecanethiolate N,N-didesmethylvenlafaxine 1-[cyano(4-methoxyphenyl)methyl]cyclohexanol O-desmethylvenlafaxine tert-butyl 2-(4-(benzyloxy)phenyl)-2-(1-hydroxycyclohexyl)carbamate 1-[2-amino-1-(4-benzyloxyphenyl)ethyl]cyclohexanol

合成工艺路线路线简述

对羟基苯乙腈置于甲酸,Palladium 10% On Activated Carbon,氢气,Potassium Carbonate,Potassium Hydroxide体系中,用甲醇,水,丙酮,甲苯用作溶剂,-20.0~25.0 °C,1.2 Mpa 条件下,反应 20.5H,反应生成1-[2-氨基-1-(4-羟基苯基)乙基]环己醇
参考文献:一种工业化合成去甲文拉法辛的方法
标题:一种工业化合成去甲文拉法辛的方法
摘要:本发明提供一种以对羟基苯乙腈为起始原料,经羟基保护,缩合反应,再经加压加氢及eschweiler－－clark反应得去甲文拉法辛的新工艺.该方法步骤少,操作简便,产物易于分离纯化,收率高,成本低,所用试剂均为常用试剂,是一种适合工业化生产的新工艺.

海关参考信息

2902600000-乙苯
2902700000-异丙基苯
2905122000-异丙醇
2905143000-叔丁醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-7605290-B2
优先权日:2006-07-26
标题 :Processes for the synthesis of O-desmethylvenlafaxine
发明人：NIDDAM-HILDESHEIM VALERIE; SHENKAR NATALIA; SHACHAN-TOV SHARONA
权利人:TEVA PHARMA
摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.

专利号:US-2009069601-A1
优先权日:2006-07-26
标题:Processes for the synthesis of O-desmethylvenlafaxine
发明人：NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION
权利人:NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION
摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.

专利号:US-2008221356-A1
优先权日:2006-07-26
标题:Processes for the synthesis of O-desmethylvenlafaxine
发明人：NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION
权利人:NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION
摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.

专利号:US-2009137846-A1
优先权日:2006-07-26
标题 :Processes for the synthesis of O-Desmethylvenlafaxine
发明人：NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION; FRENKEL GUSTAVO
权利人:NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION; FRENKEL GUSTAVO
摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.

专利号:WO-2008013995-A3
优先权日:2006-07-26
标题:Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine
发明人：NIDDAM-HILDESHEIM VALERIE; SHENKAR NATALIA; SHACHAN-TOV SHARONA
权利人:TEVA PHARMA; TEVA PHARMA; NIDDAM-HILDESHEIM VALERIE; SHENKAR NATALIA; SHACHAN-TOV SHARONA
摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.

专利号:WO-2009073066-A1
优先权日:2007-12-04
标题:Processes for the synthesis of o-desmethylvenlafaxine