专利号:US-2021085684-A1 优先权日:2016-07-06 标 题:Pde9 inhibitors for treatment of peripheral diseases 发明人:SVENSTRUP NIELS; PARACHIKOVA ANNA I; MCARTHUR JAMES 权利人:IMARA INC 摘要:The present invention relates to PDE9 inhibitors, their synthesis, and their use for treatment of benign prostate hyperplasia, beta thalassemia, and sickle cell disease.
专利号:CN-217188971-U 优先权日:2022-01-24 标 题 :A kind of constant temperature stirring device for synthesis of imidazole-4-methyl carboxylate
专利号:US-2541924-A 优先权日:1948-09-17 标 题 :Synthesis of substituted imidazoles 发明人:JONES REUBEN G 权利人:LILLY CO ELI
专利号:HU-T78019-A 优先权日:1995-03-31 标 题 :A method for the synthesis of substituted nitrogen-containing heterocyclic compounds
专利号:US-2008200475-A1 优先权日:2005-03-28 标题:4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors 发明人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH 权利人:PFIZER 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: (I) wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2a , R x , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:US-2009270431-A1 优先权日:2005-10-19 标 题 :Cyclopentenol Nucleoside Compounds Intermediates for their Synthesis and Methods of Treating Viral Infections 发明人:CHU DAVID C K; CHO JONG HYUN; KIM HYO-JOONG 权利人:UNIV GEORGIA RES FOUND 摘要:The present invention relates to compounds according to the structure (I), Where B is formula (Ia), formula (Ib) or formula (Ic); A is H, OR 2 or halogen (F, Cl, Br, I, preferably F or Br, more preferably F); A′ is H, OR2 or halogen (F, Cl, Br, I, preferably F or Br, more preferably F); A″ is H or OR 1 , with the proviso that when A′ is OR, A is H; and when A is OR 2 , A′ is H; X is C—R 3 or N; Y is C—R 3 or N; preferably X or Y is N and X and Y are not both simultaneously N; R 3 is H or C 1 -C 3 alkyl; D is H or NHR 2 ; E is absent or H; G is O or NHR 2 ; J is N or C—R 4 ; K is N or C—H; R 4 is H, halogen (F, Cl, Br, I), CN, —C(â•?O)NH 2 , NH 2 , NO 2 , —Câ•?C—H (cis or trans) or —C≡C—H; R a is H or CH 3 ; Each R 1 is independently H, an acyl group, a C 1 -C 20 alkyl or ether group, a phosphate, diphosphate, triphosphate, phosphodiester group; Each R 2 is independently H, an acyl group, a C 1 -C 20 alkyl or ether group;and Pharmaceutically acceptable salts, solvates or polymorphs thereof.
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2004). 摘要:Grimmett, M. R., Science of Synthesis, (2002) 12, 489. 摘要:Grimmett, M. R., Science of Synthesis, (2002) 12, 499. 摘要:Grimmett, M. R., Science of Synthesis, (2002) 12, 362.