CAS: 1795-01-3; 3-Ethylthiophene

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CAS号1468-83-3 3-乙酰基噻吩 | CAS号872-31-1 3-溴噻吩 | CAS号74-96-4 溴乙烷 | CAS号925-90-6 乙基溴化镁 | CAS号74-86-2 乙炔 | CAS号5069-23-8 2,5-二乙基噻吩 | CAS号21426-18-6 4-ethylthiophen... | CAS号88-13-1 3-噻吩甲酸 | CAS号53119-61-2 2-溴-3-乙基噻吩 | CAS号53119-57-6 2,5-二溴-3-乙基噻吩

3-乙酰基噻吩置于氢氧化钾,一水合肼体系中,用 乙二醇 用作溶剂,化学反应 1.0H,以86%的收率获得3-乙基噻吩
参考文献:大鼠小脑中的低亲和力pcp位点不仅结合tcp样结构,而且还结合btcp样结构.
标题:大鼠小脑中的低亲和力pcp位点不仅结合tcp样结构,而且还结合btcp样结构.
摘要:尽管这种结构缺乏多巴胺能神经,但强效多巴胺(da)再摄取抑制剂1-[1-(2-(苯并[b]硫代苯基)环己基]哌啶(btcp)的同源物却能够在大鼠小脑中结合结局.与先前的研究相一致的一个假设是,即使它们不与前脑中的高亲和力pcp位点结合,它们也可以与大鼠小脑中以[3H] Tcp标记的低亲和力pcp位点结合.制备了1-[1-(2-(硫代苯基)环己基]哌啶(tcp)和具有修饰的芳族部分且在环己基环中具有o或s原子取代的btcp的类似物,并在大鼠前脑和小脑膜的竞争实验中进行了测试用[3H] Tcp标记,在大鼠纹状体膜中用[3H] Btcp标记.结果表明,Btcp和同源物可以与大鼠小脑中以[3H] Tcp标记的低亲和力pcp位点结合,对da转运蛋白的选择性降低.相反,某些tcp类似物对这些低亲和力位点显示出非常高的选择性.它们可能是阐明这些部位尚未发现的性质和功能的重要药理工具.
Doi:10.1016/s0223-5234(00)00135-5

专利信息

专利号:US-2008125587-A1
优先权日:2006-05-25
标 题 :Synthesis of triazole compounds that modulate HSP90 activity
发明人：CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
权利人:CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
摘要:The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula: n n n n n n n n n n with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent. n In one embodiment, the present invention is a method of synthesis of a compound of formula (IA) n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA) n n n n n n n n n n with an oxidizing agent, thereby producing a compound of formula (IA). n The present invention is also directed to a method of preparing a compound or a tautomer thereof represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof. The method comprises the step of reacting a first starting compound represented by the following Structural Formula: n n n n n n n n n n in the presence of a mercuric salt, with a second starting compound represented by the following Structural Formula:

专利号:US-6245937-B1
优先权日:1996-11-29
标题 :Liquid phase parallel synthesis of chemical libraries
发明人：CHENG SOAN; SAUNDERS JOHN
权利人:DUPONT PHARMACEUTICALS RES LAB
摘要:This invention features methods of biphasic synthesis for synthesizing combinatorial libraries and combinatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this invention.

专利号:US-8653231-B2
优先权日:2007-05-31
标题:Synthesis of conducting polymer nanofibers using an oligomer of a monomer as an initiator
发明人：KANER RICHARD B; SHIN KOO; TRAN HENRY HIEP D
权利人:KANER RICHARD B; SHIN KOO; TRAN HENRY HIEP D; UNIV CALIFORNIA
摘要:The present invention involves synthesizing conducting polymer nanofibers by mixing an oxidant solution with a monomer solution, which includes a monomer and an oligomer of the monomer that is used as an initiator. The oxidant solution includes an oxidizing agent, or oxidant, such as ferric chloride to oxidize the monomer, the oligomer, or both, and begin polymerization. By including an initiator in the form of the oligomer, which may have a lower oxidation potential than the monomer, the rate of polymerization is accelerated, resulting in the nanofibrous morphology. Therefore, the conducting polymer nanofibers may be synthesized without the use of surfactants, hard templates, or seeds, resulting in a simplified and accelerated polymerization process, which enhances homogenous nucleation of the conducting polymer nanofibers.

专利号:US-9802952-B2
优先权日:2013-07-15
标 题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
发明人：KOPETZKI DANIEL; MCQUADE DAVID TYLER; SEEBERGER PETER H; GILMORE KERRY
权利人:MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V; MAX-PLANK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V
摘要:The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C 1 -C 5 alcohol.

专利号:US-2016318862-A1
优先权日:2013-09-25
标 题:Synthesis of delta 12-pgj3 and related compounds
发明人：NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.

专利号:EP-4198027-A1
优先权日:2021-12-14
标题:Sustainable process for the synthesis of molecules with antihistamine activity in unconventional biodegradable solvents (deep eutectic solvents)
发明人：QUIVELLI ANDREA FRANCESCA; CAPRIATI VITO; PERNA FILIPPO MARIA; VITALE PAOLA; ROSSI FEDERICO VITTORIO; GARCÃ?A - Ã?LVAREZ JOAQUÃ?N
权利人:UNIV DEGLI STUDI DI BARI; UNIV OVIEDO
摘要:The present invention relates to a sustainable synthetic process for obtaining ethylenediamines molecules with antihistamine activity whose production costs are considerably reduced by employing unconventional biodegradable solvents, such as the Deep Eutectic Solvents, with considerable advantages from a point of view both of the environmental and economic impact.