CAS: 2469-34-3; 13-(Chloromethyl)-2,3-Dihydroxy-4,6A,11,11,14B-Pentamethyl-2,3,4A,5,6,7,8,9,10,12,12A,13,14,14A-Tetradecahydro-1H-Picene-4,8A-Dicarboxylic Acid
该化合物是结构复杂,包括类固醇骨干和各种功能组,有助于其溶解性和再活动.Senegenin以其增强呼吸功能的能力著称,并经常在治疗呼吸条件下研究其潜在的治疗用途.此外,它可能具有抗氧化性特性,使其在天然产品研究和药理学领域引起兴趣,继续评估其安全情况和临床环境中的功效,强调进一步研究其行动机制和潜在健康惠益的重要性.
- 英文名称13-(Chloromethyl)-2,3-Dihydroxy-4,6A,11,11,14B-Pentamethyl-2,3,4A,5,6,7,8,9,10,12,12A,13,14,14A-Tetradecahydro-1H-Picene-4,8A-Dicarboxylic Acid
- 中文名称远志皂苷元
- IUPAC名称(2S,3R,4S,4aR,6aR,8aR,12aS,13S,14aR,14bR)-13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4,4a,5,6,6a,7,8,9,10,11,12,12a,13,14,14a,14b-octadecahydropicene-4,8a(1H)-dicarboxylic acid
- 其它别名27-Norolean-13-ene-23,28-dioicacid, 12-(chloromethyl)-2b,3b-dihydroxy- (7CI,8CI); Senegenin(6CI); 12-(Chloromethyl)-2b,3b-dihydroxy-27-norolean-13-ene-23,28-dioicacid
- CAS编号2469-34-3
- MFCD编号:MFCD00466906
- EINECS号:683-152-6
- FDA UNII编号:06S1QH951L
- 分子式:C30H45ClO6
- 分子量:537.13
- 产品CID: 1196392
- 产品分类生物化工 → 提取物
物理性质
MSDS等安全信息
欧盟法规
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海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905310000-1,2-乙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CN-1604963-A
优先权日:2001-11-05
标 题:In Vitro Synthesis of Short Double-Stranded RNAs
专利号:CN-104220602-A
优先权日:2012-02-01
标 题 :Materials and methods for the synthesis of error-minimized nucleic acid molecules
专利号:CN-105523960-A
优先权日:2016-02-25
标题:Synthesis of a novel pH-responsive dual emission wavelength fluorescent molecular probe and its application in bioimaging
专利号:CN-101633655-A
优先权日:2002-08-02
标 题 :Dehydrophenylahistine and its analogues and synthesis of dehydrophenylahistine and its analogues
专利号:CN-104370905-A
优先权日:2014-10-22
标题:Synthesis of Bcl-2 Inhibitor ABT-199
专利号:CN-102250982-A
优先权日:2011-06-20
标题:Method for promoting microbial synthesis of ascomycin by exogenous additives and preparation of seed solution and culture medium
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主要参考文献
1: Jia H, Chen X, Liang Z, Liang R, Wu J, Hu Y, Cui W, Zhang X. Senegenin regulates the mechanism of insomnia through the Keap1/Nrf2/PINK1/Parkin pathway mediated by GAD67. J Sleep Res. 2024 Oct
8:e14354. doi: 10.1111/jsr.14354. Epub ahead of print. 16(9):3994-4005. doi: 10.4251/wjgo.v16.i9.3994.
3: Zeng Q, Luo Y, Sang X, Liao M, Wen B, Hu Z, Sun M, Luo Z, Huang X, Liu W, Tang S. Senegenin Attenuates Pulmonary Fibrosis by Inhibiting Oxidative-Stress- Induced Epithelial Cell Senescence through Activation of the Sirt1/Pgc-1α Signaling Pathway. Antioxidants (Basel). 2024 May 31;13(6):675. doi: 10.3390/antiox13060675.
合成参考文献
摘要:CRC Handbook of Antibiotic Compounds, Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980, 8(2)(259), 1982
参考文献:10.1016/j.neulet.2004.05.093
摘要:Jia H, Jiang Y, Ruan Y, Zhang Y, Ma X, Zhang J, Beyreuther K, Tu P, Zhang D. Tenuigenin treatment decreases secretion of the Alzheimer's disease amyloid beta-protein in cultured cells. Neurosci Lett. 2004 Aug 26;367(1):123–8. doi: 10.1016/j.neulet.2004.05.093.
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