CAS: 261952-01-6; 4-Methyl-3-(Trifluoromethyl)Benzoic Acid

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CAS号948553-14-8 4-溴甲基-3-三氟甲基苯甲酰氯 | CAS号116419-94-4 4-甲基-3-(三氟甲基)苯甲酸甲酯 | CAS号863248-28-6 4-(溴甲基)-3-(三氟甲基...

4-甲基-3-三氟甲基苯甲腈置于水,Sodium Hydroxide,盐酸体系中,用 乙醇,水 用作溶剂,化学反应 6.0H,反应生成4-甲基-3-(三氟甲基)苯甲酸
参考文献:Silver-Catalyzed C-h Trifluoromethylation Of Arenes Using Trifluoroacetic Acid As The Trifluoromethylating Reagent
标题:Silver-Catalyzed C-h Trifluoromethylation Of Arenes Using Trifluoroacetic Acid As The Trifluoromethylating Reagent
摘要:Direct Trifluoromethylation Of Arenes Using Tfa As The Trifluoromethylating Reagent Was Achieved With Ag As The Catalyst. This Reaction Not Only Provides A New Protocol For Aryl Ch Trifluoromethylation,But The Generation Of Cf3 From Tfa May Prove Useful In Other Contexts And Could Potentially Be Extended To Other Trifluoromethylation Reactions.
Doi:10.1021/ol503189J

专利信息

专利号:US-2011281893-A1
优先权日:2010-05-11
标 题 :Compound, synthesis, composition and uses thereof
发明人：KANDULA MAHESH
权利人:KANDULA MAHESH; KRISANI BIOSCIENCES P LTD
摘要:The instant application provides the disclosure for a compound of formula I, synthesis of compound of formula I and its pharmaceutical acceptable salts, as well as its polymorphs, solvates, and hydrates thereof. The pharmaceutically acceptable salt may be formulated for oral administration, systemic administration, transdermal administration and injection. The compound of formula I and its pharmaceutical compositions may be used to treat cancer in mammal.

专利号:US-12227528-B2
优先权日:2017-11-09
标 题:Glucose-sensitive albumin-binding derivatives
发明人：KRUSE THOMAS; KOFOD-HANSEN MIKAEL; MUENZEL MARTIN WERNER BORCHSENIUS; THOEGERSEN HENNING; SAUERBERG PER; EWALD JAKOB; BEHRENS CARSTEN; HOEG-JENSEN THOMAS; BALSANEK VOJTECH; DROBNAKOVA ZUZANA; DROZ LADISLAV; HAVRANEK MIROSLAV; KOTEK VLADISLAV; STENGL MILAN; SNAJDR IVAN; DRUSANOVA HANA
权利人:NOVO NORDISK AS
摘要:This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

专利号:EP-4227313-B1
优先权日:2017-11-09
标题:1-hydroxy-4-(trifluoromethyl)-1,3-dihydrobenzo[c] [1,2]oxaborole-6-carboxylic acid and its use in the synthesis of glucose-sensitive albumin-binding derivatives

专利号:US-2008096883-A1
优先权日:2004-08-11
标题 :Trifluoromethyl substituted benzamides as kinase inhibitors
发明人：CARAVATTI GIORGIO; FURET PASCAL; IMBACH PATRICIA; MARTINY-BARON GEORG; PEREZ LAWRENCE BLAS; SHENG TAO
权利人:CARAVATTI GIORGIO; FURET PASCAL; IMBACH PATRICIA; MARTINY-BARON GEORG; PEREZ LAWRENCE BLAS; SHENG TAO
摘要:The invention relates to trifluoromethyl substituted benzamide compounds of the formula (I), pharmaceuticals comprising these compounds, their use as or for the manufacture of pharmaceuticals, particularly as inhibitors of protein kinases and/or the treatment of a condition, disorder or disease state mediated by a protein kinase activity and/or a proliferative disease, methods of treatment comprising administering the compounds, especially of therapeutic and prophylactic treatment, methods for the manufacture of the compounds and novel intermediates and partial steps for their synthesis.