CAS: 3261-05-0; 5-Chlorobenzofuran-3-One

该化合物是一种氯化的苯并呋喃衍生物,在有机合成和制药中间应用方面有显著的用途,其结构以活性3-1细胞和氯替代成分为主,能够有选择地发挥作用,对建设复杂的环环绕框架很有价值;化合物在标准条件下具有稳定性,便于处理和储存;其电子退出氯组增强了核生殖替代和交叉反应的再活动性,为医药化学和材料科学研究提供了多种用途;可提供高纯度,以确保合成途径的再生性;对于受控制的环境来说,它可充当开发生物活性分子和特殊化学品的先质.

英文名称5-Chlorobenzofuran-3-One
中文名称5-氯苯并呋喃-3(2H)-酮
IUPAC名称5-chlorobenzofuran-3(2H)-one
其它别名5-氯-3-苯并呋喃酮; 5-Chlorobenzofuran-3-One
CAS编号3261-05-0
MFCD编号:MFCD00091066
EINECS号:997-521-7
分子式:C8H5ClO2
分子量:168.58
产品CID: 1317526
产品分类有机原料→分子砌块→芳杂环类化合物→苯并呋喃类化合物

相似结构搜索
InChIKey: QQCUCXUMVSGDJH-UHFFFAOYSA-N
InChI=1S/C8H5ClO2/c9-5-1-2-8-6(3-5)7(10)4-11-8/h1-3H,4H2…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数0.0

相似化合物

3260-94-4 3260-78-4 5590-44-3

MSDS等安全信息

GHS符号GHS07
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P264-P270-P280-P302+P352-P330-P362+P364-P501

欧盟法规

C&L通报

上下游产品

2-carboxymethoxy-5-chloro-benzoic acid 2-chloro-1-(5-chloro-2-hydroxy-phenyl)-ethanone diazomethane N-methyl-N-nitrosotoluene-p-sulfonamide 5-chloro-2-morpholin-4-ylmethyl-benzofuran-3-ol 8-chloro-10H-benzofuro[3,2-b]indole 5-chloro-2,3-dihydro-benzofuran-3-ylamine 2-chloro-N-(5-chloro-2,3-dihydro-3-benzofuryl)acetamide

合成工艺路线路线简述

5-氯代水杨酸置于硫酸,Potassium Tert-Butylate,Potassium Carbonate体系中,用四氢呋喃,丙酮作为反应溶剂,化学反应 122.0H,反应生成 5-氯-3-苯并呋喃酮
参考文献: Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators[fr] Nouveaux Hétéroaryl-Imidazoles Et Hétéroaryl-Triazoles à Titre De Modulateurs De Gamma-Sécrétase
标题: Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators[fr] Nouveaux Hétéroaryl-Imidazoles Et Hétéroaryl-Triazoles à Titre De Modulateurs De Gamma-Sécrétase
摘要:所述化合物及其药学上可接受的盐被披露,其中所述化合物具有如下式的结构;(i)如规范中定义的那样.相应的药物组合物,治疗方法,合成方法和中间体也被披露.

海关参考信息

2902600000-乙苯
2903919090-氯苯
2908191000-对氯苯酚
2912110000-甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2012053165-A1
优先权日:2009-03-03
标题:Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators
发明人：ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG
权利人:ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2012202787-A1
优先权日:2009-10-20
标题:Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators
发明人：AM ENDE CHRISTOPHER WILLIAM; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN
权利人:AM ENDE CHRISTOPHER WILLIAM; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I; n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.