CAS: 4707-33-9; 2,2-Dimethyl-3,4-Dihydro-2H-Benzo[g]Chromene-5,10-Dione
该化合物是一种过于显露的酶,这种特性使得有选择性的红氧化循环,产生反应性氧物种(ROS)并诱发恶性细胞中的流行性疾病.α-拉帕松也表现出了抗炎和抗微生物效应,扩大了其潜在的治疗用途.它的NQO1阳性细胞的行动和选择性机制使它成为有针对性的癌症治疗研究的有前途的候选体.该化合物通常用于生物化学和药理研究,以研究氧化性应激途径和止热策略.
- 英文名称2,2-Dimethyl-3,4-Dihydro-2H-Benzo[g]Chromene-5,10-Dione
- 中文名称α-拉杷醌
- IUPAC名称2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
- 其它别名β-Lapachone; 2,2-Dimethyl-3,4,5,10-Tetrahydro-2H-Naphtho[2,3-B]Pyran-5,10-Dione; 3,4-Dihydro-2,2-Dimethyl-2H-Naphtho[2,3-B]Pyran-5,10-Dione; 2,2-Dimethyl-3,4-Dihydrobenzo[g]Chromene-5,10-Dione; Lapachoone-Alpha; 2H-Naphtho[2,3-B]Pyran-5,10-Dione, 3,4-Dihydro-2,2-Dimethyl-; α-Lapachone; 2,2-Dimethyl-3,4-Dihydro-2H-Benzo[g]Chromene-5,10-Dione
- CAS编号4707-33-9
- MFCD编号:MFCD00022287
- FDA UNII编号:VPE3AOX9QV
- 分子式:C15H14O3
- 分子量:242.27
- 产品CID: 1465366
- 产品分类天然产物 → 醌类
物理性质
MSDS等安全信息
上下游产品
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α-Lapachone Diacetate置于air,硫酸,溶剂黄146体系中,化学反应生成 Alpha-拉杷醌
参考文献:The Constitution Of Lapachol And Its Derivatives. Part V. The Structure Of Paternò'S "isolapachone"1,2
标题:The Constitution Of Lapachol And Its Derivatives. Part V. The Structure Of Paternò'S "isolapachone"1,2
摘要:
DOI:10.1021/ja01298A033
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2905122000-异丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-5763625-A
优先权日:1995-04-25
标 题:Synthesis and use of β-lapachone analogs
发明人：BOOTHMAN DAVID A; FRYDMAN BENJAMIN J; WITIAK DONALD T
权利人:WISCONSIN ALUMNI RES FOUND
摘要:3-Substituted-β-lapachone analogs and their use either alone or to augment chemotherapy or radiotherapy to induce programmed neoplastic cell death without exhibiting toxicity to surrounding normal cells are disclosed. In particular, 3-allyl-β-lapachones, 3-alkyl-β-lapachones and 3-halo-β-lapachones were found to be Topoisomerase (Topo I) inhibitors. When these analogs are used alone there is a reversible single-strand break in the DNA of neoplastic cells causing apoptosis and cell death in some cells. However, when these analogs are combined with chemotherapy or X-irradiation, an irreversible Topo I-mediated break is achieved. A new and more efficient chemical synthesis of the compounds is also disclosed.
专利号:CN-106243104-B
优先权日:2016-07-21
标 题:A kind of p-naphthoquinone and pyrimidine hybrid and its synthesis method
专利号:CN-106243104-A
优先权日:2016-07-21
标题:A kind of p-naphthoquinone and pyrimidine hybrid and its synthesis method
专利号:CN-108329319-A
优先权日:2018-01-18
标题:A kind of 1,4-naphthoquinone derivative and its synthesis method and medical application
专利号:CN-104530062-B
优先权日:2015-01-07
标 题 :A kind of 1,4-naphthoquinone derivative and its synthesis method
专利号:CN-104530062-A
优先权日:2015-01-07
标题 :A kind of 1,4-naphthoquinone derivative and its synthesis method
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合成参考文献
参考文献:10.1016/j.bmc.2008.03.032
摘要:da Silva Júnior EN, de Souza MCBV, Fernandes MC, Menna-Barreto RFS, Pinto MDCFR, de Assis Lopes F, de Simone CA, Andrade CKZ, Pinto AV, Ferreira VF, de Castro SL. Synthesis and anti-Trypanosoma cruzi activity of derivatives from nor-lapachones and lapachones. Bioorganic & Medicinal Chemistry. 2008 May;16(9):5030–8. doi: 10.1016/j.bmc.2008.03.032.
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